Effect of Acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis

Castro, Caroline Tianeze de; Gama, Romana Santos; Pereira, Marcos; Oliveira, Márcio Galvão; Dal-Pizzol, Tatiane S.; Barreto, Maurício L.; Santos, Djanilson Barbosa dos

doi:10.1080/14740338.2022.2020246

Cited by 6 publications

(2 citation statements)

References 67 publications

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“…In particular, the third trimester of pregnancy was not signi cantly associated with preterm labor, low birth weight, and small for gestational age. 19 The pharmacovigilance, clinical pharmacology of acetaminophen in pre-term and term neonates, and premature ductus arteriosus closure case-level clinical review with data mining analysis data concluded that it is reasonable that acetaminophen may be at least a contributory cause of premature ductus arteriosus closure. 20,21 Of the top 20 AEs associated with ibuprofen, spontaneous abortion (26.79%) and oligohydramnios (17.74%) were the most frequent.…”

Section: Discussionmentioning

confidence: 99%

Analysis of potential risks between acetaminophen and ibuprofen use during pregnancy via the FAERS database

Duan,

Wang,

Liao

et al. 2024

Preprint

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Purpose: The aim of this study was to compare the potential risks of acetaminophen and ibuprofen use during pregnancy in relation to adverse events (AEs) from real-world practice via the FAERS database. Methods: We detected signals of the AEs of acetaminophen and ibuprofen use during pregnancy by data mining using FAERS database. Disproportionality analysis was used to the FAERS for the suspected pregnancy data from January 2017 to December 2022. Results: On the basis of 51,936 acetaminophen reports, the reports of 331 (0.64% of total adverse drug reactions, ADRs) were associated with pregnancy; On the basis of 84,810 ibuprofen reports, the reports of 530 (0.62%) were associated with pregnancy. Among acetaminophen reports, the most AE was exposure during pregnancy (59.52%) that belongs to injury, poisoning and procedural complications. The associated pregnancy outcome of those reports was missing may suggest no cause serious consequences. Among ibuprofen reports, the major AE was abortion spontaneous (26.79%), and oligohydramnios (17.74%). Conclusion: This is the first study of comprehensively compare and analyze the potential risks between acetaminophen and ibuprofen for drug-associated adverse fetal and pregnancy outcomes by assessing the reported AEs from the real-world database. The results suggested acetaminophen may be the better choice during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Analysis of potential risks between acetaminophen and ibuprofen use during pregnancy via the FAERS database

Duan,

Wang,

Liao

et al. 2024

Preprint

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“…The highest risk was conferred by the NSAID-APAP combination ( Zafeiri et al, 2021 ). Conversely, APAP exposure during the third trimester was not associated with an increased risk of preterm birth and low birth weight ( Castro et al, 2021 ). Similarly, APAP exposure from 4 weeks before pregnancy until delivery and during pubertal development has not been associated with male puberty disorders (based on the examination of secondary genital organs, pubic hair, adult voice, first ejaculation) in more than 7,000 boys.…”

Section: Nonsteroidal Anti-inflammatory Drugs and Analgesics: Use And...mentioning

confidence: 99%

Using Experimental Models to Decipher the Effects of Acetaminophen and NSAIDs on Reproductive Development and Health

et al. 2022

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Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin (acetylsalicylic acid), diclofenac and ibuprofen (IBU), and analgesic drugs, such as acetaminophen (APAP, or paracetamol), are widely used to treat inflammation and pain. APAP and IBU are over-the-counter drugs and are among the most commonly taken drugs in the first trimester of pregnancy, even in combination. Furthermore, these drugs and their metabolites are released in the environment, and can be frequently detected in wastewater, surface water, and importantly in drinking water. Although their environmental concentrations are much lower than the therapeutics doses, this suggests an uncontrolled low-dose exposure of the general population, including pregnant women and young children, two particularly at risk populations. Epidemiological studies show that exposure to these molecules in the first and second trimester of gestation can favor genital malformations in new-born boys. To investigate the cellular, molecular and mechanistic effects of exposure to these molecules, ex vivo studies with human or rodent gonadal explants and in vivo experiments in rodents have been performed in the past years. This review recapitulates recent data obtained in rodent models after in utero or postnatal exposure to these drugs. The first part of this review discusses the mechanisms by which NSAIDs and analgesics may impair gonadal development and maturation, puberty development, sex hormone production, maturation and function of adult organs, and ultimately fertility in the exposed animals and their offspring. Like other endocrine disruptors, NSAIDs and APAP interfere with endocrine gland function and may have inter/transgenerational adverse effects. Particularly, they may target germ cells, resulting in reduced quality of male and female gametes, and decreased fertility of exposed individuals and their descendants. Then, this review discusses the effects of exposure to a single drug (APAP, aspirin, or IBU) or to combinations of drugs during early embryogenesis, and the consequences on postnatal gonadal development and adult reproductive health. Altogether, these data may increase medical and public awareness about these reproductive health concerns, particularly in women of childbearing age, pregnant women, and parents of young children.

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The relationship of prenatal acetaminophen exposure and attention-related behavior in early childhood

Woodbury,

Geiger,

Schantz

2024

Neurotoxicology and Teratology

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Effect of Acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis

Cited by 6 publications

References 67 publications

Analysis of potential risks between acetaminophen and ibuprofen use during pregnancy via the FAERS database

Analysis of potential risks between acetaminophen and ibuprofen use during pregnancy via the FAERS database

Using Experimental Models to Decipher the Effects of Acetaminophen and NSAIDs on Reproductive Development and Health

The relationship of prenatal acetaminophen exposure and attention-related behavior in early childhood

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