Effect of acetazolamide on cough induced by low-chloride-ion solutions in normal subjects: Comparison with furosemide

Foresi, Antonio; Cavigioli, G; Pelucchi, Andrea; Mastropasqua, Berardino; Marazzini, L

doi:10.1016/s0091-6749(96)70263-4

Cited by 12 publications

(5 citation statements)

References 24 publications

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“…Furosemide was also shown to inhibit PGF 2a -induced cough (Ventresca et al, 1992). In a randomized, doubleblind study of healthy volunteers challenged with low chloride ion-concentration aerosols, the carbonicanhydrase inhibitor acetazolamide demonstrated a significantly better antitussive effect than furosemide, suggesting that inhibition of carbonic anhydrase activity may be involved in modulating the effects of low chloride ion concentrations within the airway microenvironment (Foresi et al, 1996).…”

Section: H CL 2 Pump Inhibitorsmentioning

confidence: 99%

Antitussive Drugs—Past, Present, and Future

Dicpinigaitis

Morice

Birring

et al. 2014

Pharmacological Reviews

163

115

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Section: H CL 2 Pump Inhibitorsmentioning

confidence: 99%

Antitussive Drugs—Past, Present, and Future

Dicpinigaitis

Morice

Birring

et al. 2014

Pharmacological Reviews

163

115

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“…Treatment with a pendrin inhibitor already in clinical use (acetazolamide) decreases lung inflammatory pathology in infected mice. It also reduces cough in human volunteers (18), suggesting that it may be used as a novel therapy for pertussis disease.…”

Section: Virulence Factors and Pathogenesismentioning

confidence: 98%

Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development

Carbonetti

König

Lan

et al. 2016

Clin Vaccine Immunol

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Pertussis is a severe respiratory disease caused by infection with the bacterial pathogen Bordetella pertussis. The disease affects individuals of all ages but is particularly severe and sometimes fatal in unvaccinated young infants. Other Bordetella species cause diseases in humans, animals, and birds. Scientific, clinical, public health, vaccine company, and regulatory agency experts on these pathogens and diseases gathered in Buenos Aires, Argentina from 5 to 8 April 2016 for the 11th International Bordetella Symposium to discuss recent advances in our understanding of the biology of these organisms, the diseases they cause, and the development of new vaccines and other strategies to prevent these diseases. Highlights of the meeting included pertussis epidemiology in developing nations, genomic analysis of Bordetella biology and evolution, regulation of virulence factor expression, new model systems to study Bordetella biology and disease, effects of different vaccines on immune responses, maternal immunization as a strategy to prevent newborn disease, and novel vaccine development for pertussis. In addition, the group approved the formation of an International Bordetella Society to promote research and information exchange on bordetellae and to organize future meetings. A new Bordetella.org website will also be developed to facilitate these goals.

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“…Furosemide is a loop diuretic, and suppressed cough induced by low-chloride solutions but not by capsaicin (Foresi et al 1996;Karlsson et al 1992;Mochizuki et al 1995;Stone et al 1993a;Ventresca et al 1990). This drug blocks the Na + /K + /2Cl − cotransporter expressed in the peripheral terminals of the 'cough' receptor in guinea pigs (Mazzone and McGovern 2006) and laryngeal RARs in the dog (Sant'Ambrogio et al 1993).…”

Section: Ion Channel Modulatorsmentioning

confidence: 99%

“…Dextromethorphan (Grattan et al 1995;Karttunen et al 1987) (Braman 2006) × ( ± (Danzon et al 1988;Lilienfield et al 1976) ± (Dicpinigaitis and Gayle 2003b) Primarily used as an antiallergic drug (Ventresca et al 1990) (Foresi et al 1996;Stone et al 1993b;Ventresca et al 1990) Glaucine × (Rees and Clark 1983) (Ruhle et al 1984) (Gastpar et al 1984) Local anaesthetics (Choudry et al 1990;Hansson et al 1994) (Sheppard et al 1983) (Midgren et al 1992) (Chong et al 2005;Fuller and Jackson 1990;Trochtenberg 1994) β 2 −agonists × (Smith et al 1991) (Higenbottam 1987;Lowry et al 1987) ...…”

Section: Challenges To the Development Of Novel Antitussive Drugsmentioning

confidence: 99%

Peripheral Mechanisms II: The Pharmacology of Peripherally Active Antitussive Drugs

Spina

McFadzean

Bertram

et al. 2009

Pharmacology and Therapeutics of Cough

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Cough is an indispensable defensive reflex. Although generally beneficial, it is also a common symptom of diseases such as asthma, chronic obstructive pulmonary disease, upper respiratory tract infections, idiopathic pulmonary fibrosis and lung cancer. Cough remains a major unmet medical need and although the centrally acting opioids have remained the antitussive of choice for decades, they have many unwanted side effects. However, new research into the behaviour of airway sensory nerves has provided greater insight into the mechanisms of cough and new avenues for the discovery of novel non-opioid antitussive drugs. In this review, the pathophysiological mechanisms of cough and the development of novel antitussive drugs are reviewed.

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Effect of acetazolamide on cough induced by low-chloride-ion solutions in normal subjects: Comparison with furosemide

Cited by 12 publications

References 24 publications

Antitussive Drugs—Past, Present, and Future

Antitussive Drugs—Past, Present, and Future

Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development

Peripheral Mechanisms II: The Pharmacology of Peripherally Active Antitussive Drugs

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