Effect of Acetoacetate and  -Hydroxybutyrate on Vitamin B12 in Rats

Abstract

The intermediary compounds involved in blood urea and inorganic phosphate (4). These fat metabolism, acetoacetate and P-hydroxy-ketone bodies also showed increased cholesbutyrate on prolonged administration have terol/phospholipid ratio ( 5 ) , disturbances in been shown to cause increase in bloo'd sugar the balance of hepatic glycogenesis and ( 1 ), blood lactic and pyruvic acids ( 2,3), and glycogenolysis ( 6), decrease in reduced at UNIV OF MICHIGAN on June 26, 2015 ebm.sagepub.com Downloaded from

Effect Different Fats and Essential Fatty Acids on Vitamin B12 Level in Plasma and Liver

“…Saturated fats have also been shown to be more ketogenic than the unsaturated ones (12). Recently ketone bodies have been found to increase the vitamin B12 requirement in rats (11). In the present investigation also the same relationship between vitamin B12 and ketone bodies is observed.…”

“…Severity of vitamin B12 deficiency has also been shown to increase by increasing the fat content of the diets (10). Fat intermediate meta bolites, ketone bodies, have recently been shown to cause depletion of vitamin B12 in blood and liver of rats (11). Further, saturated fats have been found to be more ketogenic than the unsaturated ones (12).…”

Effect of Various High Protein Diets on Vitamin B12 Status in Rats

“…Nath and Nath (10) have demonstrated a significant decrease in vitamin B12 levels in ketone bodies injected animals. It was also found that the effect of various high fat diets on the levels of this vitamin varied in accordance with their ketogenic petency.…”

Studies on the Role of Hydrolysed Glucose Cyclo-acetoacetate on the Restoration of the Activities of Certain Enzymes in Scorbutic Guinea Pigs

“…GCA, which has been shown to maintain the reduced glutathione level (28,29), might possibly prevent the inhibition of these enzymes by retaining the normal level of reduced glutathione of the cell.…”