Effect of acetylcholine on mast cells of the dura mater

Мотавкин, П. А.; Черток, В. М.; Shul'ga, S. D.

doi:10.1007/bf00806702

Cited by 12 publications

(10 citation statements)

References 4 publications

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“…description of guinea pig (D'Ermo & Cricchi, 1963) and rat (Selye et al, 1963) dura mater. Since that time, dural mast cells have been (1) associated with the vasculature (Giordano-Lanza et al, 1972), (2) discussed incidentally (Olsson, 1968;Markowitz et al, 1989;Theoharides, 1990), (3) used as a subject for 'degranulation' studies (D'Ermo & Cricchi, 1963;Gabbiani et al, 1970;Motavkin et al, 1979), and (4) cited as a potential contaminant in the study of brain histamine content (Orr, 1984). Although one report depicts what might be a mast cell (Andres et al, 1987), no electron microscopic study of rat dura has described the mast cell as a component of that tissue (Pease & Schultz, 1958;Andres, 1967;Waggener & Beggs, 1967;Andres et at., 1987).…”

Section: Identification Of Serotonin Fluorescent Cells As Mast Cellsmentioning

confidence: 97%

Linear arrays of homogenous mast cells in the dura mater of the rat

et al. 1991

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Using fluorescence histochemistry, 5-HT, histamine and heparin were colocalized in a large population of cells in the dura mater thereby identifying them as mast cells. In addition, because these cells were highly sensitive to compound 48/80 and were densely packed with granules of a consistent density, they were identified specifically as 'connective tissue' mast cells. Other types of mast cells, i.e. 'mucosal' or 'neurolipomastocytes', were not present in the rat dura mater. 5-HT immunohistochemistry was the best technique for demonstrating that there were populations of mast cells, one associated with each of the two layers of dura. Although shaped differently the type of mast cell in each layer was the same. It was observed that mast cell shape is dependent on the contiguity, density and orientation of its surrounding elements, not its type. In general, mast cells in the outer layer were aligned parallel to the middle meningeal artery and those in the inner layer were parallel to trigeminal nerve branches that coursed obliquely across the middle meningeal artery. Examination of cross-sections of dura revealed that most mast cells also were aligned at the interface between the two dural layers. The linear orientation of mast cells in two planes of each layer suggests a programmed lamellar seeding of these cells during development of the dura. This study also demonstrated that the majority of dural mast cells were more closely related to other connective tissue elements than to blood vessels and nerves. These results (1) are compatible with the suggestion that dural mast cells play a non-obligatory role in the neuroinflammatory response, (2) leave open to question the role of the dural mast cell in headache or the regulation of blood flow, and (3) support evidence that dural mast cells play an important role in connective tissue related functions, e.g. development, inflammatory response to injury and wound repair.

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Section: Identification Of Serotonin Fluorescent Cells As Mast Cellsmentioning

confidence: 97%

Linear arrays of homogenous mast cells in the dura mater of the rat

et al. 1991

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“…Hence, the "vascular regulation gradient" underlies the vasomotor regulation in the pia mater [4,6] in animals of all age groups; in other words, redistribution of the signi¿ cance of this or that regulatory mechanisms with changes in the vascular diameters. Myogenic EIDV reaction predominates in the 1st-3rd order arterial branches in adult animals, while the EDVD predominates in the 5th order vessels.…”

Section: Resultsmentioning

confidence: 99%

“…Part of the blood volume À ows into the thickness of the brain via the precortical arterioles, the other part is shunted due to numerous anastomoses with the adjacent vessels without getting into the intracerebral network. This organization of pial vessels provides rapid redistribution of the blood and adequate blood supply to neurons in case of local changes in the functional activity of the brain [3,4].…”

Section: Resultsmentioning

confidence: 99%

“…In contrast to 3-month-old rats, the myogenic reaction of 24-month-old animals predominated in the 1st and 2nd order branches and the endotheliumdependent one in the 4th and 5th order branches. Vascular reactivity of 24-month-old rats was lower than in younger rats in all cases.The regulatory mechanisms of the pia mater arte ries often attract the attention of scientists [3,4]. The vascular endothelium is now more and more often assumed to play the key role in hemodynamic regulation [10,13].…”

mentioning

confidence: 99%

“…The regulatory mechanisms of the pia mater arte ries often attract the attention of scientists [3,4]. The vascular endothelium is now more and more often assumed to play the key role in hemodynamic regulation [10,13].…”

mentioning

confidence: 99%

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Age-Associated Characteristics of Vasomotor Regulation of the Pia Mater Arteries in Rats

Черток

Kotsyuba

2010

Bull Exp Biol Med

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The endothelium-dependent and myogenic reactions of pia mater arteries of the 1st-5th branching orders were studied in 1-, 3-, and 24-month-old rats by biomicroscopy method. The endothelium-independent (myogenic) reaction predominated in the 1st-3rd order branches and the endothelium-dependent vascular reaction in the 5th order branches of 3-month-old rats. Both regulatory mechanisms were equally developed in the 4th order branches. In 1-month-old rats, the endothelium-dependent reaction was more active in the majority of branches. In 24-month-old rats, this reaction was significantly higher than the endothelium-independent one only in the 4th and 5th order branches. In contrast to 3-month-old rats, the myogenic reaction of 24-month-old animals predominated in the 1st and 2nd order branches and the endothelium-dependent one in the 4th and 5th order branches. Vascular reactivity of 24-month-old rats was lower than in younger rats in all cases.

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Sympathetic innervation of the supratentorial dura mater of the rat

Keller

Marfurt

Dimlich

et al. 1989

J of Comparative Neurology

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The origin, density, and distribution of sympathetic nerve fibers in the supratentorial dura mater of the rat were examined in detail in the current study by using wheat germ agglutinin horseradish peroxidase (WGA-HRP) retrograde tracing procedures, glyoxylic acid-induced fluorescence, and dopamine beta-hydroxylase (DBH) immunocytochemical staining of dural whole mount preparations. Application of WGA-HRP to the superior sagittal sinus and adjacent areas of the supratentorial dura mater labeled numerous neurons in each of the left and right superior cervical ganglia. Glyoxylic acid and DBH immunocytochemical staining of fixed dural whole mount preparations revealed prominent plexuses of sympathetic nerves about the middle meningeal artery and its branches, about the superior sagittal and transverse sinuses, and "free" within the dura mater, i.e., apparently unassociated with any vasculature. Significantly, in all of these areas, the density of sympathetic innervation revealed in this study was considerably greater than that previously demonstrated by other workers. An impressive population of mast cells also was observed within the dura mater of the glyoxylic acid-treated preparations. The majority of these cells were perivascular; however, a significant number were also present within the dura unrelated to the vasculature, and occasional cells were seen in close apposition to fluorescent sympathetic nerve fibers. Taken together, the identification of a robust sympathetic plexus and prominent mast cell population associated with a dura mater that also receives significant sensory projections from the trigeminal system raises interest regarding the functional interactions of these elements. These observations warrant further consideration regarding their role in the pathogenesis of vascular headache and head pain.

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Effect of acetylcholine on mast cells of the dura mater

Cited by 12 publications

References 4 publications

Linear arrays of homogenous mast cells in the dura mater of the rat

Linear arrays of homogenous mast cells in the dura mater of the rat

Age-Associated Characteristics of Vasomotor Regulation of the Pia Mater Arteries in Rats

Sympathetic innervation of the supratentorial dura mater of the rat

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