Effect of Acetylcysteine (Mucomyst) on Epithelial Wound Healing

Petroutsos, G.; Guimarães, Ricardo Queiroz; Giraud, J.P.; Renard, G; Pouliquen, Y.

doi:10.1159/000265198

Cited by 24 publications

(21 citation statements)

References 14 publications

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“…They reported that the healing of normal superficial epithelial ulcers is not affected by acetylcysteine. The nontoxicity and some improving effects of acetylcysteine in the present study are slightly similar to those of Absolon and Brown [4], Brown and Weller [7], Berman [11], Williamson et al [9], Frauenfelder et al [12], Marsh and Cooper [13], Burns et al [24], Sugar and Waltman [16] and Petroutsos et al [15].…”

Section: Discussionsupporting

confidence: 88%

“…Petroutsos et al [15] showed that 20 and 10% concentrations of acetylcysteine had no toxicity on epithelial wound in rabbits. They reported that the healing of normal superficial epithelial ulcers is not affected by acetylcysteine.…”

Section: Discussionmentioning

confidence: 99%

“…Corneal toxicity of NAC was observed after intracorneal injection [14]. Evaluation of those effects on the cornea and the mucus was performed using light microscopy [15,16] and histochemistry [17]. Although different treatments with NAC were described, the effective dose without undue toxicity has not been established.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Acetylcysteine on Experimental Corneal Wounds in Dogs

Aldavood¹,

Behyar²,

Sarchahi³

et al. 2003

Ophthalmic Res

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The effects of 3, 10 and 20% concentrations of acetylcysteine on experimental corneal wound healing in dogs were evaluated. Experimental corneal wounds were induced surgically, up to the depth of the anterior third of the stroma, in both eyes of 18 dogs. One of the eyes was treated topically with 0.9% NaCl solution three times a day. The contralateral eye was treated topically with acetylcysteine (3, 10 and 20% concentrations) in each of 6 cases separately. Corneal wounds were measured by fluorescein staining every day. The mean time of healing in the 3% group was significantly different from control eyes (6.17 ± 1.94 days). It was 7.19 ± 0.75 days in the 20% group and 7 ± 2 days in the 10% group. The last two groups were not significantly different from the controls (9.67 ± 3.01 days and 8.17 ± 3.60 days, respectively).

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Effect of Acetylcysteine on Experimental Corneal Wounds in Dogs

Aldavood¹,

Behyar²,

Sarchahi³

et al. 2003

Ophthalmic Res

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“…In previous experiments carried out in this Department, acetylcysteine was used as an inhibitor of collagenolytic activity [23]. The present study suggests a more efficient effect of L -fucose on iodine vapor-burnt corneas.…”

Section: Discussionsupporting

confidence: 54%

Studies on Corneal Wound Healing

Isnard

Bourles-Dagonet²,

Robert³

et al. 2005

Ophthalmologica

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Corneal wound healing often leads to the development of scar tissue with loss of transparency. Reconstitution of transparent corneal stroma depends on the regulation of the biosynthetic activities of postlesional keratocytes and also to a large extent on the limitation of matrix degradation, attributed essentially to the upregulation of matrix metalloproteases and especially MMP-9. Using a standardized method for the production of reproducible corneal lesions by burning with iodine vapors, we could show that the local application of 0.5 mg/ml L-fucose reduced significantly MMP-9 upregulation and accelerated the recovery of the epithelial layer of the cornea. The iodine vapor used in the experiments produces a rapid loss of epithelium with no or slight effect below the basement membrane. A relatively rapid regrowth of epithelium was observed. The speed of this reepithelialization was stimulated by the local application of fucose. At 48 h after burn, there was a difference between fucose-treated and control corneas (epithelial thickness was about 50 µm for fucose-treated corneas and 37 µm for control corneas). Culture media of in vivo fucose-treated corneas showed an important decrease of MMP-9 activity (–51%, n = 6, p < 0.01). It appears that the in vivo fucose treatment reduced the MMP-9 activity released in the media. This effect is significant 24 h after iodine vapor burn. In order to study the effect of fucose on normal corneas, it was added to rabbit as well as human cornea explant cultures, and the production and release of MMP-9 was determined by zymography. Fucose at a concentration of 0.5 mg/ml produced a 70% decrease of MMP-9 activity released in the medium by corneal explant cultures. Other mono- and oligosaccharides were also tested. Besides lactose, fucose-rich oligosaccharides also produced significant inhibition. Galactose, melibiose, mannose and glucose were inactive. These results justify the use of fucose for the local treatment of corneal wounds.

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“…Despite of previous studies had referred that proteinase inhibitors may be capable to accelerate the process of reepithelialization (Aldavood et al 2003), it was observed that it doesn't interfere at the corneal healing rate (Petroutsos et al 1982, Aldavood et al 2003. Nevertheless, authors suggest its administration in every case of indolent ulcer aiming to reduce the proteolytic activity of the ocular surface and to give support to corneal tissue on its restructuration (Berman 1975, Burns et al 1989.…”

Section: Discussionmentioning

confidence: 99%

Retrospective study on clinical management of indolent ulcers in Boxer dogs

et al. 2011

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Indolent ulcers are superficial corneal ulcers secondary to several changes on the corneal surface. They are frequently observed in middle-aged Boxer dogs, cause pain of acute onset and requires appropriate treatment. Aiming to evaluate the efficacy of clinical managements on the rate of healing of indolent ulcers, a retrospective study was conducted (1997-2008). Results demonstrated that proteinase inhibitors were the most often prescribed medication, and its administration did not interfere on the healing rate, as well as observed in dogs that received 1% atropine, antibiotics and anti-inflammatory drugs. Healing was delayed in dogs administered orally with vitamin C, but the healing process was faster on those dogs that went through corneal debridement/cauterization. In conclusion, to know the various types of treatments seems to be fundamental for the rapid resolution of the disease. It is suggested that debridement/cauterization, administration of proteinase inhibitor eye drops, prophylactic topical antibiotics and oral vitamin C, should be considered as an effective clinical management for indolent ulcers in Boxer dogs.

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Effect of Acetylcysteine (Mucomyst) on Epithelial Wound Healing

Cited by 24 publications

References 14 publications

Effect of Acetylcysteine on Experimental Corneal Wounds in Dogs

Effect of Acetylcysteine on Experimental Corneal Wounds in Dogs

Studies on Corneal Wound Healing

Retrospective study on clinical management of indolent ulcers in Boxer dogs

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