Effect of Actidione (Cycloheximide) on Yeast Fermentation

Abstract

Actidione, an antibiotic produced by Streptomyces griseus, is highly active against a large number of yeasts but it has no marked antibacterial activity. Of 22 species of yeasts tested by Whiffen (1948), 9 were completely inhibited by 0.17 jig drug per ml; Saccharomyces cerevisae

A history of research on yeasts 9: regulation of sugar metabolism1

“…This finding was also confirmed for fructose bisphosphatase [124] and phosphoenolpyruvate carboxykinase [264]. Further evidence of a proteolytic degradation came from the observation that phenylmethanesulphonyl fluoride (PMSF), an inhibitor of serine‐proteases,67 prevented the inactivation of α‐isopropylmalate synthase in permeabilized cells [45] and also prevented the inactivation of isocitrate lyase and fructose bisphosphatase in normal (non‐permeabilized) cells [146].…”

Synthesis of Chiral Tryptamines via a Regioselective Indole Alkylation

“…Chiral tryptamines are frequently encountered in pharmacology, because of their significant biological activities in the central nervous system . In addition, the chiral tryptamine moiety serves as the synthetic precursor of many medicinally important indole alkaloids and is found in numerous biologically active natural products and pharmaceuticals (see Figure ).…”

Azepinoindoles. I. Hexahydroazepino[4,5-b]indoles

“…Our continued interest in the pharmacologic activity of indole derivatives on the mammalian central nervous system1 2led us to prepare a series of 1,2,3,4,5,6hexahydroazepino [4,[5][6] [indoles (1). Formally, these compounds may be considered to be tryptamine derivatives in which the spatial orientation of the basic nitrogen is limited by the conformational restrictions of the seven-membered ring.…”

“…Prolonged tryptamine-like activity has been observed5 with the a-alkyltryptamines which are not oxidized by monoamine oxidase and actually serve as competitive inhibitors of the enzyme. 6 It is also noteworthy that several /3-carboline derivatives, structurally related to the azepinoindoles under discussion, are reversible inhibitors of monoamine oxidase.7 8Our interest in the subject compounds was enhanced by the reported3 central-stimulant activity of ibogaine (2), an alkaloid which incorporates the hexahydroazepino [4,[5][6] [indole system in its rather complex structure.…”