Effect of Acupuncture on Neuroplasticity of Stroke Patients with Motor Dysfunction: A Meta-Analysis of fMRI Studies

Lv, Qiuyi; Xu, Guixing; Pan, Yuxin; Liu, Tongtong; Liu, Xiaodong; Miao, Linqing; Chen, Xing; Jiang, Lan; Chen, Jie; He, Yingjia; Zhang, Rong; Zou, Yihuai

doi:10.1155/2021/8841720

Cited by 22 publications

(11 citation statements)

References 54 publications

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“…Motor dysfunction is one of the most common complications following stroke, which manifests as numbness and weakness of the limbs and even paralysis or spasms [ 13 , 52 ]. Motor dysfunction can seriously affect the quality of life and social participation of stroke patients.…”

Section: The Role Of Music Therapy In the Rehabilitation Poststrokementioning

confidence: 99%

Potential Benefits of Music Therapy on Stroke Rehabilitation

Shen

et al. 2022

Oxidative Medicine and Cellular Longevity

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Stroke is associated with a high rate of disability and mortality, and survivors are usually accompanied with dysphagia, aphasia, motor dysfunction, cognitive impairment, depression, and other complications. In the past decades, many studies have been conducted to reveal the pathogenesis and pathological mechanisms of stroke. Furthermore, treatment methods have been developed that contribute to the elevated survival rate of stroke patients. Early rehabilitation poststroke is starting to be recognized as important and has been receiving increasing attention in order to further improve the quality of life of the patients. As an emerging method of poststroke rehabilitation, music therapy can help attenuate dysphagia and aphasia, improve cognition and motor function, alleviate negative moods, and accelerate neurological recovery in stroke patients. This review helps summarize the recent progress that has been made using music therapy in stroke rehabilitation and is aimed at providing clinical evidence for the treatment of stroke patients.

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Section: The Role Of Music Therapy In the Rehabilitation Poststrokementioning

confidence: 99%

Potential Benefits of Music Therapy on Stroke Rehabilitation

Shen

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Although none of the studies had a clear study protocol, all expected outcome indicators were reported, including predetermined ones. We prefer to consider studies with two or more secondary outcome indicators reported to be at low risk for selectively reported data ( 24 ). Therefore, six studies had a low risk of bias in selective reporting, except Zhao's research ( 21 ).…”

Section: Resultsmentioning

confidence: 99%

Effect of acupuncture on the modulation of functional brain regions in migraine: A meta-analysis of fMRI studies

Huang²,

Yao³

et al. 2023

Front. Neurol.

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BackgroundAcupuncture, a traditional Chinese medicine therapy, is an effective migraine treatment, especially in improving pain. In recent years, many acupuncture brain imaging studies have found significant changes in brain function following acupuncture treatment of migraine, providing a new perspective to elucidate the mechanism of action of acupuncture.ObjectiveTo analyse and summarize the effects of acupuncture on the modulation of specific patterns of brain region activity changes in migraine patients, thus providing a mechanism for treating migraine by acupuncture.MethodsChinese and English articles published up to May 2022 were searched in three English databases (PubMed, Embase and Cochrane) and four Chinese databases (China national knowledge infrastructure, CNKI; Chinese Biomedical Literature database, CBM; the Chongqing VIP database, VIP; and the Wanfang database, WF). A neuroimaging meta-analysis on ALFF, ReHo was performed on the included studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) software. Subgroup analyses were used to compare differences in brain regions between acupuncture and other groups. Meta-regression was used to explore the effect of demographic information and migraine alterations on brain imaging outcomes. Linear models were drawn using MATLAB 2018a, and visual graphs for quality evaluation were produced using R and RStudio software.ResultsA total of 7 studies comprising 236 patients in the treatment group and 173 in the control group were included in the meta-analysis. The results suggest that acupuncture treatment helps to improve pain symptoms in patients with migraine. The left angular gyrus is hyperactivation, and the left superior frontal gyrus and the right superior frontal gyrus are hypoactivated. The migraine group showed hyperactivation in the corpus callosum compared to healthy controls.ConclusionAcupuncture can significantly regulate changes in brain regions in migraine patients. However, due to the experimental design of neuroimaging standards are not uniform, the results also have some bias. Therefore, to better understand the potential mechanism of acupuncture on migraine, a large sample, multicenter controlled trial is needed for further study. In addition, the application of machine learning methods in neuroimaging studies could help predict the efficacy of acupuncture and screen migraine patients suitable for acupuncture treatment.

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“…The NIH Consensus Conference ( 14 ) and publications ( 15 , 16 ) have demonstrated that acupuncture can improve the neurological motor deficit symptoms and become an acceptable alternative method for stroke rehabilitation. Recent research has shown that acupuncture was involved in regulating neural plasticity in patients with stroke, both functionally and structurally ( 17 , 18 ). Yanglingquan (GB34), the He-Sea point of the gall bladder meridian (Foot-Shaoyang), the confluence point of tendons, is one of the main points in post-stroke acupuncture approaches, such as Wang's twelve-needling at hands and feet method and Xingnao Kaiqiao needling method ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

Sensorimotor Responses in Post-Stroke Hemiplegic Patients Modulated by Acupuncture at Yanglingquan (GB34): A fMRI Study Using Intersubject Functional Correlation (ISFC) Analysis

Wang

et al. 2022

Front. Neurol.

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Motor dysfunction is common in patients with stroke. Acupuncture has become an acceptable alternative method for stroke rehabilitation. Previous studies have shown various functional connectivity changes activated by acupuncture. We introduced intersubject correlation (ISC) and intersubject functional correlation (ISFC) analyses into the functional magnetic resonance imaging (fMRI) for ischemic stroke to seek a common activation and suppression pattern triggered by acupuncture. In this study, 63 ischemic stroke patients with motor dysfunction and 42 normal controls were analyzed. Three functional scans were conducted during the resting state, motor task, and acupuncture at Yanglingquan (GB34) task. Twenty-two sensory, motor, and movement-imagination cortices in the bilateral hemispheres were selected as the region of interest (ROI). We performed ISC and ISFC analyses among these ROIs in three fMRI runs on patients and controls. Subgroup analyses by course or severity were also conducted. The results showed that acupuncture at GB34 triggered ISFC among upper limb motor, upper limb/hand/face, lower limb, tongue/larynx sensory, and movement imagination regions in the patient group. Subgroup ISC and ISFC analyses showed that patients tended to have increasing responses in the early stage of stroke (within 1 month) and decreasing responses afterward (1–3 months). Patients with mild clinical functional damage (NIHSS 2–4) tended to generate more responses via acupuncture than those with moderate damage (NIHSS 5–15). Our findings may help understand the clinical effects and modulatory features of acupuncture based on the group-level post-stroke neuroplasticity.

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Effect of Acupuncture on Neuroplasticity of Stroke Patients with Motor Dysfunction: A Meta-Analysis of fMRI Studies

Cited by 22 publications

References 54 publications

Potential Benefits of Music Therapy on Stroke Rehabilitation

Potential Benefits of Music Therapy on Stroke Rehabilitation

Effect of acupuncture on the modulation of functional brain regions in migraine: A meta-analysis of fMRI studies

Sensorimotor Responses in Post-Stroke Hemiplegic Patients Modulated by Acupuncture at Yanglingquan (GB34): A fMRI Study Using Intersubject Functional Correlation (ISFC) Analysis

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