Effect of Acupuncture on Polycystic Ovary Syndrome in Animal Models: Study Protocol for a Systematic Review and Meta-Analysis

Gao, Jin-Ying; Li, Wei; Li, Yangyang; Li, Yan

doi:10.21203/rs.3.rs-144670/v1

Cited by 2 publications

(7 citation statements)

References 18 publications

(20 reference statements)

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“…There was no restriction on language or date. We included studies published in peer-reviewed journals only [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

“…Acupuncture without needling was excluded, such as acupressure, acupoint injection, tap pricking, and cupping. The comparison group included PCOS animals induced by the same method as the intervention group but without undergoing the intervention [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

“…The following outcome measures were used [ 17 ]: Primary outcome: homeostatic model assessment-insulin resistance (HOMA-IR: (fasting insulin ( μ U/mL) × fasting glucose (mmol/L))/22.5). Secondary outcomes: testosterone (T), LH (luteinizing hormone), LH/follicle-stimulating hormone (FSH) ratio, fasting blood sample (FBG), fasting insulin (FINS), and body weight (BW).…”

Section: Methodsmentioning

confidence: 99%

“…PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and the Chinese Science and Technology Periodical Database (VIP) were searched from inception to December 20, 2020. The main terms “Polycystic ovary syndrome”, “Acupuncture”, and “Animal Experimentation”, indexed in the MeSH system, were combined [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

“…The presence of heterogeneity was evaluated by I 2 and chi-square statistical analyses. Funnel plots were performed to evaluate publication bias if there were more than ten studies included [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

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Effect of Acupuncture on Polycystic Ovary Syndrome in Animal Models: A Systematic Review

Zhang

Gao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. As a widely used complementary and alternative therapy, acupuncture is increasingly used to treat PCOS. However, the effect of acupuncture in treating PCOS is uncertain, and the mechanisms are unclear. This systematic review aims to determine the efficacy of acupuncture on PCOS in animal preclinical models. Methods. Experimental animal studies of acupuncture in PCOS animal models were searched in PubMed, Web of Science, China National Knowledge Infrastructure, and the Chinese Science and Technology Periodical Database from inception to December 2020. The risk of bias was assessed using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) risk of bias tool. Results. A total of 358 studies were screened based on the title and abstract, and 31 studies were included. A total of 722 animals were involved, and all studies used either Wistar rats or SD rats. Twenty-six studies used electroacupuncture, 9 studies used manual acupuncture, and 5 of them employed both electroacupuncture and manual acupuncture. A total of 22 acupoints were involved; 7 studies followed the modern acupuncture pattern, and the rest followed classic acupuncture theory. Conclusions. The present review summarizes the current evidence of the effects of acupuncture on PCOS in animal models. Unfortunately, we could not draw a definite conclusion due to the methodological weakness of the included studies and the high heterogeneity. Well-designed studies are needed in the future to fill this gap.

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“…There was no restriction on language or date. We included studies published in peer-reviewed journals only [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Effect of Acupuncture on Polycystic Ovary Syndrome in Animal Models: A Systematic Review

Zhang

Gao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The efficacy and safety of metformin combined with simvastatin in the treatment of polycystic ovary syndrome

Liu¹,

Shao²,

Xie³

et al. 2021

Medicine

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Background: Several previous randomized controlled trials (RCTs) evaluated the efficacy of metformin combined with simvastatin in the treatment of polycystic ovary syndrome (PCOS), yet the results of the researches are not consistent. It is necessary to conduct a meta-analysis to explore the efficacy and safety of metformin combined with simvastatin in the treatment of PCOS, to provide evidence supports for the treatment of PCOS.Methods: We searched PubMed, EMbase, Cochrane Library, China National Knowledge Infrastructure, Wanfang, and Chinese biomedical literature databases online to identify the RCTs evaluating the efficacy of metformin combined with simvastatin in the treatment of PCOS. Standardized mean difference (SMD) and 95% confidence interval (95% CI) were calculated to evaluate the synthesized effects.Results: Nine RCTs with a total of 746 PCOS patients were included. The synthesized results indicated that the combined use of metformin and simvastatin are more beneficial to reduce the total cholesterol (SMD -2.66, 95% CI -3.65 to -1.66), triglycerides (SMD -1.25, 95% CI -2.02 to -0.49), low density lipoprotein (SMD -2.91, 95% CI -3.98 to -1.84), testosterone (SMD -0.64, 95% CI -1.13 to -0.15), fasting insulin (SMD -1.17, 95% CI -2.09 to -0.26) than metformin alone treatment in PCOS patients (all P < .001), and there was no significant difference in the high density lipoprotein (SMD -0.05, 95% CI -0.56-0.46), luteinizing hormone (SMD -0.58, 95% CI -1.66 to -0.50), follicle stimulating hormone (SMD 0.41, 95% CI -0.78-1.59), prolactin (SMD -1.38, 95% CI -2.93-0.17), fasting blood sugar (SMD 0.23, 95% CI -0.52-0.97), and insulin sensitivity index (SMD -0.17, 95% CI -0.48-0.15) between experimental and control groups (all P > .05).Conclusions: Metformin combined with simvastatin is superior to metformin alone in the treatment of PCOS patients with more advantages in improving the levels of sex hormones, blood lipids, and blood sugar. However, the safety of this therapy still needs to be further explored in clinical studies with high-quality and large samples. Abbreviations: 95% CI = 95% confidence interval, FBS = fasting blood sugar, FIN = fasting insulin, FSH = follicle stimulating hormone, HDL = high density lipoprotein, LDL = low density lipoprotein, OR = odds ratio, PCOS = polycystic ovary syndrome, RCT = randomized controlled trial, SMD = standardized mean difference, T = testosterone, TC = total cholesterol, TG = triglycerides.

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Effect of Acupuncture on Polycystic Ovary Syndrome in Animal Models: Study Protocol for a Systematic Review and Meta-Analysis

Cited by 2 publications

References 18 publications

Effect of Acupuncture on Polycystic Ovary Syndrome in Animal Models: A Systematic Review

Effect of Acupuncture on Polycystic Ovary Syndrome in Animal Models: A Systematic Review

The efficacy and safety of metformin combined with simvastatin in the treatment of polycystic ovary syndrome

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