Effect of acupuncture stimulation on rats with depression induced by water-immersion stress

Tanahashi, Nobuyuki; Takagi, Ken; Amagasu, Nozomi; Wang, Guifeng; Mizuno, Kaito; Kawanoguchi, Jun; Guo, Yi; Ishida, Tatsuro

doi:10.1016/j.neulet.2016.02.051

Cited by 22 publications

(32 citation statements)

References 20 publications

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“…Consistent with this conclusion, we found rats with MS induced a higher level of ACTH and CORT in their plasma compared to healthy rats (Figure 2D,E), which may in part reveal the potential relationship between early life adverse stress and depression in adulthood (Choi et al, 2018; Frost et al, 2018). Notably, the EA treatment can reverse the increased concentration of ACTH and CORT in rats with MS (Figure 2D,E), which is compatible with other studies showing that EA regulates the function of the HPA axis to treat depression (Tanahashi et al, 2016). Together, these results further confirmed that EA is an effective therapy for depression induced by neonatal MS.…”

Section: Discussionsupporting

confidence: 91%

Transcriptome Analysis on Maternal Separation Rats With Depression-Related Manifestations Ameliorated by Electroacupuncture

et al. 2019

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Maternal separation (MS), a stressful event in early life, has been linked to neuropsychiatric disorders later in life, especially depression. In this study we investigated whether treatment with electroacupuncture (EA) could ameliorate depression-related manifestations in adult animals that had adverse early life experiences. We demonstrated depression-like behavior deficiencies in a sucrose preference test and a forced swimming test in a rat model with neonatal MS. Repeated EA treatment at the acupoints Baihui (GV20) and Yintang (GV29) during adulthood was shown to be remarkably attenuated above behavioral deficits. Using unbiased genome-wide RNA sequencing to investigate alterations in the transcriptome of the prefrontal cortex (PFC), we explored the altered gene sets involved in circadian rhythm and neurotransmitter transporter activity in MS rats, and their expression tended to be reversed after EA treatment. In addition, we analyzed the interaction network of differentiated lncRNA– or circRNA–miRNA–mRNA by using the principle of competitive endogenous RNA (ceRNA). These results suggest that EA at GV20 and GV29 ameliorates depression-related manifestations by regulating the expression of multiple genes.

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Section: Discussionsupporting

confidence: 91%

Transcriptome Analysis on Maternal Separation Rats With Depression-Related Manifestations Ameliorated by Electroacupuncture

et al. 2019

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“…Suicide is the second leading cause of death in young men and suicidal behaviors are mostly occur in psychiatric patients, especially patients with depressive disorders (1). It seems that one of the underlying mechanisms of depression is the HPA axis (8). The HPA axis dysfunction can be reflected in the levels of cortisol (3) so that high levels of cortisol have been reported in suicide attempters with depression (2).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effectiveness of Auricular Acupuncture in Suicidal Ideation and Cortisol Level in Dysthymic Patients with Comorbid Opiate Use Disorders Enrolled in Methadone Maintenance Treatment: A Randomized, Double-Blind, Sham-Controlled Trial

Pirnia

Mohammadi

Zahiroddin

et al. 2019

Iran J Psychiatry Behav Sci

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Background: Suicide is one of the leading causes of death around the world. The hypothalamic-pituitary-adrenal (HPA) axis disorder is involved in the pathophysiology of suicidal behavior. Acupuncture by regulating the activity of the HPA axis could regulate the secretion of cortisol. Objectives: This study aimed to evaluate the effectiveness of auricular acupuncture in the reduction of cortisol level and suicidal ideation in dysthymic patients with comorbid opiate use disorders enrolled in methadone maintenance treatment (MMT). Methods: In a randomized, double-blind, sham-controlled trial (TCTR20180328001), from December 2015 to June 2016, 24 patients (mean age = 24 years) with persistent depressive disorder (dysthymia) under methadone maintenance treatment who referred to Bijan Center for Substance Abuse Treatment in Tehran were selected through respondent-driven sampling (RDS). After 28 days of evaluation, the participants were randomized into two active or sham continuous groups. Auricular acupuncture was performed twice a week for four weeks for the experimental group while the control group received the sham acupuncture. Assessments were carried out before treatment (baseline) and every week for four weeks. Salivary cortisol was considered the primary outcome and the suicide ideation was the secondary outcome. The data were analyzed by the generalized estimation equation (GEE) model and the chi-square test. The qualitative data were analyzed using ATLAS/TI 5 software. Results: Acupuncture had a significant effect on the cortisol level, as the primary outcome, during the four weeks of treatment. Moreover, there was a significant reduction in suicidal ideation as the secondary outcome (all P values < 0.01). Conclusions: Acupuncture as an alternative method could reduce the cortisol level and significantly decrease suicidal ideation.

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“…Therefore, some patients are seeking complementary and alternative medicine for depression to avoid polypharmacy and take treatment that is more effective. In fact, there are several reports about effectiveness of complementary and alternative treatment such as acupuncture or traditional herbal medicine [3][4][5][6][7]. Acupuncture and traditional herbal medicine have been utilized as a treatment for physical and mental disorders in traditional Oriental medicine for a long time [8,9].…”

Section: Introductionmentioning

confidence: 99%

Specific Effectiveness of Acupuncture and Kampo Medicine on Mice with Depression

Nishimura

2020

JCMAH

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Although early recovery and prevention of depression are important in modern society, antidepressant, that is often the primary pharmacotherapy, produces unwanted adverse effects. We investigated preventive and therapeutic effects, and additionally difference of monotherapy and combined therapy using major traditional medicines, i.e. Kampo (Japanese traditional herbal medicine, saikokaryukotsuboreito) and acupuncture (GV20 and Ex-HN3 as acupoints), which have much less side effects than Western medicine, compared with imipramine measuring immobility time brought by forced swimming (FS) stress. Furthermore, we analyzed its mechanisms according to changes in neurotrophic factors by molecular biology/biochemical method. All the intervention groups in the preventive evaluation and the therapeutic groups in the therapeutic evaluation did not worsen immobility time, and improved prolonged immobility time induced by FS stress respectively. However, there was no significant difference in the time between either the intervention groups or the therapeutic groups. BDNF and NT-3 in acupuncture and combined groups were higher than those in FS group both in the preventive and the therapeutic groups. NGF in the combined group was as same as FS group, and higher than that in acupuncture, Kampo, and imipramine groups in both the preventive and the therapeutic groups. These findings suggest that acupuncture and Kampo improve depression through the regulation of neurotrophic factors, of which mechanism is different from imipramine, and that combined therapy has specific anti-depressive mechanism that does not exert in acupuncture or Kampo alone. We need to utilize more depression rating scales to evaluate the effect of combined therapy more precisely.

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Effect of acupuncture stimulation on rats with depression induced by water-immersion stress

Cited by 22 publications

References 20 publications

Transcriptome Analysis on Maternal Separation Rats With Depression-Related Manifestations Ameliorated by Electroacupuncture

Transcriptome Analysis on Maternal Separation Rats With Depression-Related Manifestations Ameliorated by Electroacupuncture

Evaluation of the Effectiveness of Auricular Acupuncture in Suicidal Ideation and Cortisol Level in Dysthymic Patients with Comorbid Opiate Use Disorders Enrolled in Methadone Maintenance Treatment: A Randomized, Double-Blind, Sham-Controlled Trial

Specific Effectiveness of Acupuncture and Kampo Medicine on Mice with Depression

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