Effect of Acute Alcohol Ingestion on Resistance Exercise–Induced mTORC1 Signaling in Human Muscle

Duplanty, Anthony A.; Luk, Hui Ying; Levitt, Danielle E.; Hill, David W.; McFarlin, Brian K.; Huggett, Duane B.; Vingren, Jakob L.

doi:10.1519/jsc.0000000000001468

Cited by 25 publications

(25 citation statements)

References 50 publications

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“…Furthermore, to allow an appropriate inflammatory response, nonsteroidal anti-inflammatory drug consumption was not allowed 48 h before and 24 h after the exercise session Blood sampling and analyses. Blood samples were obtained at PRE, post-damage, IP, and ϩ15, ϩ30, and ϩ60 and processed using standard procedures in our laboratory (10). Briefly, blood was collected from an antecubital vein into vacuum-sealed tubes using an indwelling catheter.…”

Section: E422mentioning

confidence: 99%

Resistance exercise-induced hormonal response promotes satellite cell proliferation in untrained men but not in women

Luk

Levitt

Boyett

et al. 2019

American Journal of Physiology-Endocrinology and Metabolism

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The purpose of this work was to determine the effect of resistance exercise (RE)-induced hormonal changes on the satellite cell (SC) myogenic state in response to muscle damage. Untrained men ( n = 10, 22 ± 3 yr) and women ( n = 9, 21 ± 4 yr) completed 2 sessions of 80 unilateral maximal eccentric knee extensions followed by either an upper body RE protocol (EX) or a 20-min rest (CON). Muscle samples were collected and analyzed for protein content of Pax7, MyoD, myogenin, cyclin D1, and p21 before (PRE), 12 h, and 24 h after the session was completed. Serum testosterone, growth hormone, cortisol, and myoglobin concentrations were analyzed at PRE, post-damage, immediately after (IP), and 15, 30, and 60 min after the session was completed. Testosterone was significantly ( P < 0.05) higher immediately after the session in EX vs. CON for men. A significant time × sex × condition interaction was found for MyoD with an increase in EX (men) and CON (women) at 12 h. A significant time × condition interaction was found for Pax7, with a decrease in EX and increase in CON at 24 h. A significant time effect was found for myogenin, p21, and cyclin D1. Myogenin and p21 were increased at 12 and 24 h, and cyclin D1 was increased at 12 h. These results suggest that the acute RE-induced hormonal response can be important for men to promote SC proliferation after muscle damage but had no effect in women. Markers of SC differentiation appeared unaffected by the hormonal response but increased in response to muscle damage.

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Section: E422mentioning

confidence: 99%

Resistance exercise-induced hormonal response promotes satellite cell proliferation in untrained men but not in women

Luk

Levitt

Boyett

et al. 2019

American Journal of Physiology-Endocrinology and Metabolism

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“…4EBP1 is phosphorylated on four different residues (Thr 37 , Thr 46 , Ser 65 , and Ser 70 ) in a mTORC1-dependent manner, with the most common in human skeletal muscle being Thr 37/46 . Results surrounding the effect of anabolic stimuli on this phosphorylation site are equivocal, with some studies reporting elevations (5,42,62,96,121,124) and others showing no change or even reductions (43,49,95,96). These findings may be due to the hierarchical nature of 4EBP1 phosphorylation following mTORC1 activation (66), as this particular site may no longer be phosphorylated at certain time points.…”

Section: Eukaryotic Translation Initiation Factor 4e-binding Proteinmentioning

confidence: 99%

Molecular regulation of human skeletal muscle protein synthesis in response to exercise and nutrients: a compass for overcoming age-related anabolic resistance

Hodson

West

Philp

et al. 2019

American Journal of Physiology-Cell Physiology

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Skeletal muscle mass, a strong predictor of longevity and health in humans, is determined by the balance of two cellular processes, muscle protein synthesis (MPS) and muscle protein breakdown. MPS seems to be particularly sensitive to changes in mechanical load and/or nutritional status; therefore, much research has focused on understanding the molecular mechanisms that underpin this cellular process. Furthermore, older individuals display an attenuated MPS response to anabolic stimuli, termed anabolic resistance, which has a negative impact on muscle mass and function, as well as quality of life. Therefore, an understanding of which, if any, molecular mechanisms contribute to anabolic resistance of MPS is of vital importance in formulation of therapeutic interventions for such populations. This review summarizes the current knowledge of the mechanisms that underpin MPS, which are broadly divided into mechanistic target of rapamycin complex 1 (mTORC1)-dependent, mTORC1-independent, and ribosomal biogenesis-related, and describes the evidence that shows how they are regulated by anabolic stimuli (exercise and/or nutrition) in healthy human skeletal muscle. This review also summarizes evidence regarding which of these mechanisms may be implicated in age-related skeletal muscle anabolic resistance and provides recommendations for future avenues of research that can expand our knowledge of this area.

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“…3) with protein confers no advantage in terms of muscle remodeling when a recommended protein dose is consumed. By contrast, the finding that drinking a large quantity of alcohol (1.5 g/kg, ~12 standard drinks) impaired the post-exercise MPS response to protein ingestion [41, 42] through the inactivation of mTORC1 [43] implicates a detrimental role for binge alcohol consumption during the muscle remodeling process.…”

Section: Overview Of Protein Carbohydrates and Fluidsmentioning

confidence: 99%

Selected In-Season Nutritional Strategies to Enhance Recovery for Team Sport Athletes: A Practical Overview

et al. 2017

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Team sport athletes face a variety of nutritional challenges related to recovery during the competitive season. The purpose of this article is to review nutrition strategies related to muscle regeneration, glycogen restoration, fatigue, physical and immune health, and preparation for subsequent training bouts and competitions. Given the limited opportunities to recover between training bouts and games throughout the competitive season, athletes must be deliberate in their recovery strategy. Foundational components of recovery related to protein, carbohydrates, and fluid have been extensively reviewed and accepted. Micronutrients and supplements that may be efficacious for promoting recovery include vitamin D, omega-3 polyunsaturated fatty acids, creatine, collagen/vitamin C, and antioxidants. Curcumin and bromelain may also provide a recovery benefit during the competitive season but future research is warranted prior to incorporating supplemental dosages into the athlete’s diet. Air travel poses nutritional challenges related to nutrient timing and quality. Incorporating strategies to consume efficacious micronutrients and ingredients is necessary to support athlete recovery in season.

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Effect of Acute Alcohol Ingestion on Resistance Exercise–Induced mTORC1 Signaling in Human Muscle

Cited by 25 publications

References 50 publications

Resistance exercise-induced hormonal response promotes satellite cell proliferation in untrained men but not in women

Resistance exercise-induced hormonal response promotes satellite cell proliferation in untrained men but not in women

Molecular regulation of human skeletal muscle protein synthesis in response to exercise and nutrients: a compass for overcoming age-related anabolic resistance

Selected In-Season Nutritional Strategies to Enhance Recovery for Team Sport Athletes: A Practical Overview

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