Effect of acute and chronic stress on masculine sexual behavior in the rat

Retana‐Márquez, Socorro; Salazar, Emilio Dominguez; Velázquez‐Moctezuma, Javier

doi:10.1016/0306-4530(95)00029-1

Cited by 56 publications

(44 citation statements)

References 40 publications

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“…Rats were placed individually in a cold water covered tank (15.5 cm deep, at 15 C) where they could either swim or remain in an upright position, keeping their heads above water level for 15 min. After stress induction, animals were dried with a cloth and immediately returned to their cages [Retana-Márquez et al 1996]. This procedure was done once/d for one (acute stress) or 20, 40, and 50 consecutive d (chronic stress).…”

Section: Cold Water Immersion-induced Stressmentioning

confidence: 99%

Intrinsic and extrinsic apoptotic pathways are involved in rat testis by cold water immersion-induced acute and chronic stress

Juárez-Rojas

García-Lorenzana²,

Martínez

et al. 2015

Systems Biology in Reproductive Medicine

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Testicular apoptosis is activated by stress, but it is not clear which signaling pathway is activated in response to stress. The aim of this study was to investigate whether intrinsic, extrinsic, or both apoptotic signaling pathways are activated by acute and chronic stress. Adult male rats were subjected to cold water immersion-induced stress for 1, 20, 40, and 50 consecutive days. The seminiferous tubules:apoptotic cell ratio was assayed on acute (1 day) and chronic (20, 40, 50 days) stress. Apoptotic markers, including cleaved-caspase 3 and 8, the pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins were also determined after acute and chronic stress induction. Additionally, epididymal sperm quality was evaluated, as well as corticosterone and testosterone levels. An increase in tubule apoptotic cell count percentage after an hour of acute stress and during chronic stress induction was observed. The apoptotic cells rate per tubule increment was only detected one hour after acute stress, but not with chronic stress. Accordingly, there was an increase in Bax, cleaved caspase-8 and caspase-3 proapoptotic proteins with a decrease of anti-apoptotic Bcl-2 in both acutely and chronically stressed male testes. In addition, sperm count, viability, as well as total and progressive motility were low in chronically stressed males. Finally, the levels of corticosterone increased whereas testosterone levels decreased in chronically stressed males. Activation of the extrinsic apoptotic pathway was shown by cleaved caspase-8 increase whereas the intrinsic apoptotic pathway activation was determined by the increase of Bax, along with Bcl-2 decrease, making evident a cross-talk between these two pathways with the activation of caspase-3. These results suggest that both acute and chronic stress can potentially activate the intrinsic/extrinsic apoptosis pathways in testes. Chronic stress also reduces the quality of epididymal spermatozoa, possibly due to a decrease in testosterone.

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Section: Cold Water Immersion-induced Stressmentioning

confidence: 99%

Intrinsic and extrinsic apoptotic pathways are involved in rat testis by cold water immersion-induced acute and chronic stress

Juárez-Rojas

García-Lorenzana²,

Martínez

et al. 2015

Systems Biology in Reproductive Medicine

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“…Stress is regarded as one important factor to induce sexual dysfunction. It was reported that chronic exposure to a variety of mild stressors significantly decreased male sexual behavior (Brotto et al, 1998;D'Aquila et al, 1994;Retana-Marquez et al, 1996;Sato et al, 1992;Miwa et al, 2011;Hawley et al, 2011). It had been estimated that more than 152 million men worldwide subjected to sexual dysfunction and this number might increase to approximately 322 million by the year 2025 (Aytac et al, 1999;Hawton, 1985;NIH, 1993).…”

Section: Introductionmentioning

confidence: 99%

Aphrodisiac Activity of <i>Kaempferia parviflora</i>

P.¹

2012

American Journal of Agricultural and Biological Sciences

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Problem statement:The increasing prevalence of sexual dysfunction and the limitation of therapeutic efficacy nowadays give rise to the requirement of novel therapeutic strategy. Kaempferia parviflora or Krachai-Dun has been long term used in Thai traditional folklore to treat this condition. Unfortunately, no scientific document is available until now. Therefore, this study was undertaken to determine the effect of this medicinal plant on male sexual behavior of aging rats subjected to stress. Approach: Aging rats were divided into 2 groups; the vehicle+stress and the K.parviflora+stress. All animals were administered the assigned substance 45 m before they were subjected to the 12-hr stress exposure for 3 weeks. They were determined male sexual behaviors including both latency and frequency of mounting, intromission and ejaculation behaviors after single dose and every week until the end of experimental period. In order to investigate the possible underlying mechanism, we also determined the alteration of DA1-immunopositive stained neurons density in hypothalamus. Results: Our results showed that after the single administration of the plant extract, the intromission frequency increased, it was also found the rats subjected K.parviflora treatment significantly increased the frequency of mounting, intromission and ejaculation while decreased the latencies of all sexual behaviors mentioned earlier. Moreover, K.parviflora also increased D1-immunopositive stained neurons density in hypothalamus. Therefore, the aphrodisiac activity of K.parviflora might be attributed in part to the enhanced dopaminergic function in hypothalamus. Conclusion: Present findings provide experimental evidence that the crude extract of K.parviflora can enhance male sexual behaviors. Therefore, it will be further developed as the functional food or health product for men especially for men who are risk for sexual dysfunction.

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“…For example, 2 hr of immobilization elongated intromission latency, increased number of mounts needed for an ejaculation and decreased hit rate (number of intromissions/sum of mounts and intromissions) in male rat [27]. Similarly, water immersion elongated mount, intromission and ejaculation latency, and post ejaculation interval (PEI), and it increased the number of mounts and intromissions, and decreased the hit rate [27]. In addition, we have shown that sexual behavior was also deteriorated by the alarm pheromone [16].…”

mentioning

confidence: 97%

“…In addition to sexual behavior itself, it also has been demonstrated that various types of stressors can deteriorate male sexual behavior. For example, 2 hr of immobilization elongated intromission latency, increased number of mounts needed for an ejaculation and decreased hit rate (number of intromissions/sum of mounts and intromissions) in male rat [27]. Similarly, water immersion elongated mount, intromission and ejaculation latency, and post ejaculation interval (PEI), and it increased the number of mounts and intromissions, and decreased the hit rate [27].…”

mentioning

confidence: 98%

Naloxone Blocks the Deterioration of Male Sexual Behavior Induced by Alarm Pheromone in Rats

Kobayashi

Kiyokawa

Arata

et al. 2013

The Journal of Veterinary Medical Science

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ABSTRACT. Previously, we have demonstrated that the alarm pheromone deteriorates sexual behavior in male rats, which was blocked by pretreatment with a corticotrophin-releasing hormone (CRH) antagonist. Studies have shown that an opioid antagonist blocked the deterioration of male sexual behavior following intracerebroventricular administration of CRH. Therefore, possibly, the pheromone effects could also be mediated by the opioid system. In this study, we pretreated rats with naloxone, an opioid receptor antagonist, and examined the following sexual behavior modulations in male rats that were exposed to the alarm pheromone. Naloxone blocked the deterioration of sexual behavior in a dose-dependent manner. On the basis of these data and the results of the previous study, we conclude that the alarm pheromone activates the CRH system, which then activates the opioid system, to deteriorate male sexual behavior. KEY WORDS: alarm pheromone, naloxone, opioid, rat, sexual behavior.doi: 10.1292/jvms.12-0454; J. Vet. Med. Sci. 75(6): 761-765, 2013 Sexual behavior is one of the most important activities for organisms and has been studied for many years. In addition to sexual behavior itself, it also has been demonstrated that various types of stressors can deteriorate male sexual behavior. For example, 2 hr of immobilization elongated intromission latency, increased number of mounts needed for an ejaculation and decreased hit rate (number of intromissions/sum of mounts and intromissions) in male rat [27]. Similarly, water immersion elongated mount, intromission and ejaculation latency, and post ejaculation interval (PEI), and it increased the number of mounts and intromissions, and decreased the hit rate [27]. In addition, we have shown that sexual behavior was also deteriorated by the alarm pheromone [16].We previously showed that foot-shocked male Wistar rats release an alarm pheromone, which aggravates stressinduced hyperthermia (SIH) in pheromone-exposed rats [10] via the vomeronasal system [14]. We can induce the release of this pheromone by electrical stimulation to the perianal region of the anesthetized donor rat [14]. In addition, this alarm pheromone was shown to be water-soluble, because exposure to water droplets collected from the ceiling of the box in which the alarm pheromone was released produced all responses that are observed in recipients directly exposed to the pheromone [12]. This pheromone solution allows us to observe pheromone effects in different experimental paradigms; it can evoke several responses, such as aggravated SIH in the home cage [12,14], increased defensive and risk assessment behaviors in a modified open-field test [15] and enhanced acoustic startle reflex (ASR) [7,8]. In addition to its effects on individual animals, the effects of the alarm pheromone on social behavior have been analyzed [16]. When we presented the alarm pheromone during sexual behavior, male sexual behavior was deteriorated as indicated by the increasing number of mounts and decreasing hit rate, whereas female se...

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Effect of acute and chronic stress on masculine sexual behavior in the rat

Cited by 56 publications

References 40 publications

Intrinsic and extrinsic apoptotic pathways are involved in rat testis by cold water immersion-induced acute and chronic stress

Intrinsic and extrinsic apoptotic pathways are involved in rat testis by cold water immersion-induced acute and chronic stress

Aphrodisiac Activity of <i>Kaempferia parviflora</i>

Naloxone Blocks the Deterioration of Male Sexual Behavior Induced by Alarm Pheromone in Rats

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