Effect of Acute and Chronic Administration of Carbamazepine on Cisplatin-Induced Hyperalgesia in Rats

Nayebi, Alireza Mohajjel; Sharifi, Hamdollah; Ramadzani, Mohammad; Rezazadeh, Hassan

doi:10.17795/jjnpp-3559

Cited by 8 publications

(2 citation statements)

References 10 publications

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“…The mean latency time was lowered day by day, so the most prominent decrease was observed on day fifteen. This observation is in accordance with previous studies showing CIH (Balayssac et al, 2009;Nayebi et al, 2012).…”

Section: Discussionsupporting

confidence: 94%

Silymarin reduced cisplatin-induced hyperalgesia bysuppressing oxidative stress in male rats

et al. 2021

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Introduction: Cisplatin is an antineoplastic agent which is used in treatment of various cancers. However its clinical use is associated with oxidative stress-mediated neuropathic pain. This research aimed to explore the effect of silymarin on cisplatin-induced hyperalgesia (CIH) and oxidative stress biomarkers in male rats. Methods: Fifty-six male rats were allocated into seven equal groups. Hyperalgesia was caused by intraperitoneal single dose administration of cisplatin (1mg/kg) and assessed by utilizing tail-flick method. The impact of silymarin (25, 50 and 100 mg/kg/day for 15 days) on CIH was investigated on days 1, 5, 10 and 15. Blood samples were collected to assess malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD) and total antioxidant status (TAS) on day fifteen. Results: Single dose injection of cisplatin (1mg/kg) could cause a significant hyperalgesia on days 5, 10 and 15. CIH was abolished by daily administration of silymarin (50 and 100mg/kg) on days 10 and 15. Serum MDA level was decreased in cisplatin and silymarin (100 mg/kg) co-treated rats, while there was an increase in GPx, SOD as well as TAS parameters. Conclusion: The results of this study revealed that silymarin prevents from CIH possibly by improving lipid peroxidation and oxidative stress biomarkers. Other clinical studies should be performed to establish possible use of silymarin for treatment of CIH in susceptible individuals.

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Section: Discussionsupporting

confidence: 94%

Silymarin reduced cisplatin-induced hyperalgesia bysuppressing oxidative stress in male rats

et al. 2021

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“…The result of the study showed that carbamazepine had no significant analgesic effect in this type of neuropathic pain. The opposite result was obtained in the work [214]. The analgesic effect of a single and continuous administration of carbamazepine with cisplatin (a component of chemotherapy) on peripheral neuropathic pain in rats was studied.…”

Section: Psychotropic Drugs For Management Of Pain and Itching Synmentioning

confidence: 86%

Psychotropic Drugs for the Management of Chronic Pain and Itch

Belinskaia

Barygin

et al. 2019

Pharmaceuticals

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Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit symptoms of increased anxiety, depression and cognitive impairment. Such patients need corrective therapy with antidepressants, antipsychotics or anticonvulsants. It is known that some psychotropic drugs are also effective for the treatment of neuropathic pain and pruritus syndromes due to interaction with the secondary molecular targets. Our own clinical studies have identified antipruritic and/or analgesic efficacy of the following compounds: tianeptine (atypical tricyclic antidepressant), citalopram (selective serotonin reuptake inhibitor), mianserin (tetracyclic antidepressant), carbamazepine (anticonvulsant), trazodone (serotonin antagonist and reuptake inhibitor), and chlorprothixene (antipsychotic). Venlafaxine (serotonin-norepinephrine reuptake inhibitor) is known to have an analgesic effect too. The mechanism of such effect of these drugs is not fully understood. Herein we review and correlate the literature data on analgesic/antipruritic activity with pharmacological profile of these compounds.

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