Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man

Cavagnini, Francesco; Invitti, Cecilia; Pinto, M.; Maraschini, C.; Landro, Anna Di; Dubini, A.; Marelli, A.

doi:10.1530/acta.0.0930149

Cited by 85 publications

(39 citation statements)

References 20 publications

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“…GABA given orally stimulated prolactin secretion in humans (Cavagnini et al 1980). The GABA A -benzodiazepine receptor agonists triazolam (Copinschi et al 1990) and midazolam (Frieboes et al 1994) resulted in an increase in sleep-dependent prolactin secretion in men.…”

Section: Discussionmentioning

confidence: 99%

Mg 2+ reduces ACTH secretion and enhances spindle power without changing delta power during sleep in men - possible therapeutic implications

Murck¹,

Steiger²

1998

Psychopharmacology

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Disturbances of Mg2+ metabolism have been reported in association with affective disorders, seizures in eclampsia, and alcohol withdrawal. Mg2+ has been reported to have N-methyl-D-aspartate (NMDA)-antagonistic and gamma-aminobutyric acid (GABA)-agonistic properties and modulation of GABA(A)- and NMDA-dependent systems is involved in pharmacological treatment of affective disorders and seizures. We studied the effect of Mg2+ on sleep electroencephalogram (EEG) and nocturnal hormonal secretion in men. Ten normal controls were given MgSO4 (3 g MgSO4 between 2030 hours and 2100 hours, followed by 0.5 g MgSO4 per hour until 0700 hours) or placebo i.v. according to a randomized schedule. The sleep EEG was recorded from 2300 hours to 0700 hours. Blood samples were taken from 2000 hours to 0700 hours for analysis of plasma corticotropin (ACTH), cortisol, growth hormone, prolactin and melatonin. The sleep-EEG power within the spindle frequency range (11.0-12.9 Hz) showed a significant increase in the third sleep cycle, but delta power was unchanged throughout the night. ACTH concentration was suppressed between 2200 hours and 0700 hours. No changes in cortisol, growth hormone prolactin or melatonin release were found. The findings are consistent with the assumption that Mg2+ has GABA(A)-agonistic or NMDA-antagonistic effects on sleep and nocturnal hormonal secretion and hence may be useful in controlling depressive symptoms and seizures.

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Section: Discussionmentioning

confidence: 99%

Mg 2+ reduces ACTH secretion and enhances spindle power without changing delta power during sleep in men - possible therapeutic implications

Murck¹,

Steiger²

1998

Psychopharmacology

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“…7) In animals, GABA is distributed mainly in the brain and spinal cord, and is known as one of the major inhibitory neurotransmitters in the central nervous system. 8,9) GABA has many other physiological functions, such as protecting neuronal cells, 10) reducing blood pressure in experimental animals and humans, [11][12][13][14][15] improving discrimination learning, 16) promotion of secreting growth hormone, 17) and reduction of acylglycerol in blood. 18) Thus GABA attracts attention as a promising functional and healthy food ingredient.…”

mentioning

confidence: 99%

Isolation of Marine Yeasts Collected from the Pacific Ocean Showing a High Production of γ-Aminobutyric Acid

Masuda¹,

Guo²,

Uryu³

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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Marine yeasts were collected from coastal and deep sea areas in the Pacific Ocean and the Sea of Japan around central and northern Japan to prepare a novel type of natural seasoning. It was found that one of the marine yeasts collected from the Pacific Ocean off Hachinohe showed a high concentration of -aminobutyric acid (GABA) in its extract, about 7-10 times higher than those of commercially available bread yeast and other marine yeasts. The marine yeast isolated and named Hachinohe No. 6 catalyzed the reaction from monosodium glutamate to GABA only in the presence of glucose. Subsequently, several marine yeasts belonging to the genera Pichia and Candida were found to have such catalytic activities, but not those belonging to the genus Saccharomyces. Isolate Hachinohe No. 6 was found to have the highest catalytic activity among the yeasts examined in this study.

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“…The GH plasma levels, can serve as a Surrogate Marker for assessing the GABAergic transmission in the CNS and is therefore a useful tool for dosage regimen calculation of the new antiepileptic drugs and for the right choice of therapeutic strategy, since, the oral administration of drugs that facilitates GABAergic transmission, among them the antiepileptics, cause a rise of growth hormone plasma levels, GH, in a dose-dependent manner, being GH release induced by gamma-aminobutyric acid, GABA, and mediated by a dopaminergic mechanism, via dopamine release at suprapituitary level (Cavagnini et al 1980a(Cavagnini et al , 1980bPowers et al 2008).…”

Section: Pk-pd Modelmentioning

confidence: 99%

Biomarkers and Therapeutic Drug Monitoring in Psychiatry

Lozano¹,

Marin²,

Pascual³

et al. 2012

Biomarker

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Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man

Cited by 85 publications

References 20 publications

Mg 2+ reduces ACTH secretion and enhances spindle power without changing delta power during sleep in men - possible therapeutic implications

Mg 2+ reduces ACTH secretion and enhances spindle power without changing delta power during sleep in men - possible therapeutic implications

Isolation of Marine Yeasts Collected from the Pacific Ocean Showing a High Production of γ-Aminobutyric Acid

Biomarkers and Therapeutic Drug Monitoring in Psychiatry

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