Effect of acute exercise on plasma beta‐thromboglobulin and platelet aggregation in young athletes

Pechán, J; Okrucká, A; T, Marcek

doi:10.1080/15438629109511902

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…4,5). Rheological alterations are currently linked to morbidities such as: diabetes, hereditary disorders, sickle cell, myocardial infarction, paroxysmal nocturnal hemoglobinuria, sepsis, end stage renal disease, hypertension, strokes, endothelial function, vascular health, hemostasis in athletes and blood transfusions and cancer (Hung et al 1991;Pechan et al 1991;McHedlishvili and Maeda 2001;Ahmad and El-Sayed 2003;Meiselman 2003, 2010;Piagnerelli et al 2003;Babu and Singh 2004;Meiselman et al 2007;Forsyth et al 2012;Serroukh et al 2012;Beck et al 2014;Giovanna 2014;Hierso et al 2014;Buttari et al 2015;Heber and Volf 2015;Ertan et al 2017). Interestingly, we also observed many rheological alterations in our "healthy" pilot study participants (Figs.…”

Section: Introductionmentioning

confidence: 99%

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Bio-field array: a dielectrophoretic electromagnetic toroidal excitation to restore and maintain the golden ratio in human erythrocytes

2018

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Erythrocytes must maintain a biconcave discoid shape in order to efficiently deliver oxygen (O2) molecules and to recycle carbon dioxide (CO 2) molecules. The erythrocyte is a small toroidal dielectrophoretic (DEP) electromagnetic field (EMF) driven cell that maintains its zeta potential (ζ) with a dielectric constant (ԑ) between a negatively charged plasma membrane surface and the positively charged adjacent Stern layer. Here, we propose that zeta potential is also driven by both ferroelectric influences (chloride ion) and ferromagnetic influences (serum iron driven). The Golden Ratio, a function of Phi φ, offers a geometrical mathematical measure within the distinct and desired curvature of the red blood cell that is governed by this zeta potential and is required for the efficient recycling of CO 2 in our bodies. The Bio‐Field Array (BFA) shows potential to both drive/fuel the zeta potential and restore the Golden Ratio in human erythrocytes thereby leading to more efficient recycling of CO 2. Live Blood Analyses and serum CO 2 levels from twenty human subjects that participated in immersion therapy sessions with the BFA for 2 weeks (six sessions) were analyzed. Live Blood Analyses (LBA) and serum blood analyses performed before and after the BFA immersion therapy sessions in the BFA pilot study participants showed reversal of erythrocyte rheological alterations (per RBC metric; P = 0.00000075), a morphological return to the Golden Ratio and a significant decrease in serum CO 2 (P = 0.017) in these participants. Immersion therapy sessions with the BFA show potential to modulate zeta potential, restore this newly defined Golden Ratio and reduce rheological alterations in human erythrocytes.

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Section: Introductionmentioning

confidence: 99%

“…; Pechan et al. ; McHedlishvili and Maeda ; Ahmad and El‐Sayed ; Baskurt and Meiselman , ; Piagnerelli et al. ; Babu and Singh ; Meiselman et al.…”

Section: Introductionmentioning

confidence: 99%

Bio-field array: a dielectrophoretic electromagnetic toroidal excitation to restore and maintain the golden ratio in human erythrocytes

2018

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“…76 In response to hypertension, platelets show a number of responses. Spontaneous aggregation 77 and increased sensitivity to agonists 68 has been identified in platelets from hypertensive individuals. Activated platelets in turn release different mediators, such as 5-hydroxytryptamine (5-HT or serotonin), ADP, adenosine triphosphate (ATP) and lysophosphatidic acid.…”

Section: Platelet Function In Hypertensionmentioning

confidence: 99%

The potential role of milk-derived peptides in cardiovascular disease

2011

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Bioactive peptides derived from milk proteins are of particular interest to the food industry due to the potential functional and physiological roles that they demonstrate, particularly in relation to cardiovascular disease (CVD). By 2020 it is estimated that heart disease and stroke will become the leading cause of death and disability worldwide. Acute and chronic cardiovascular events may result from alterations in the activity of the renin-angiotensin aldosterone system and activation of the coagulation cascade and of platelets. Medications that inhibit angiotensin converting enzyme (ACE) are widely prescribed in the treatment and prevention of cardiovascular disease. ACE inhibitory peptides are of particular interest due to the presence of encrypted inhibitory peptide sequences. In particular, Ile-Pro-Pro and Val-Pro-Pro are fore runners in ACE inhibition, and have been incorporated into commercial products. Additionally, studies to identify additional novel peptides with similar bio-activity and the ability to withstand digestion during transit through the gastrointestinal tract are ongoing. The potential sources of such peptides in cheese and other dairy products are discussed. Challenges to the bio-availability of such peptides in the gastro intestinal tract are also reviewed. Activation of platelets and the coagulation cascade play a central role in the progression of cardiovascular disease. Platelets from such patients show spontaneous aggregation and an increased sensitivity to agonists which results in vascular damage and endothelial dysfunction associated with CVD. Peptide sequences exhibiting anti-thrombotic activity have been identified from fermented milk products. Studies on such peptides are reviewed and their effects on platelet function are discussed. Finally the ability of food derived peptides to decrease the formation of blood clots (thrombi) is reviewed. In conclusion, due to the widespread nature of cardiovascular disease, the identification of food derived compounds that exhibit a beneficial effect in such widespread areas of CVD regulation will have strong clinical potential. Due to the perception that food derived products have an acceptable risk profile they have the potential for widespread acceptance by the public. In this review, selected biological effects relating to CVD are discussed with a view to providing essential information to researchers.

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Acute exercise-induced changes in hemostatic and fibrinolytic properties: analogies, similarities, and differences between normotensive subjects and patients with essential hypertension

Braschi¹

2019

Platelets

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Effect of acute exercise on plasma beta‐thromboglobulin and platelet aggregation in young athletes

Cited by 3 publications

References 14 publications

Bio-field array: a dielectrophoretic electromagnetic toroidal excitation to restore and maintain the golden ratio in human erythrocytes

Bio-field array: a dielectrophoretic electromagnetic toroidal excitation to restore and maintain the golden ratio in human erythrocytes

The potential role of milk-derived peptides in cardiovascular disease

Acute exercise-induced changes in hemostatic and fibrinolytic properties: analogies, similarities, and differences between normotensive subjects and patients with essential hypertension

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