Effect of Acute Exposure of Belladonna Mother Tincture on Zebrafish Embryonic Development

Sharma, Mahima; Prajapati, Suneel; Kumar, Anuj; Tripathi, Ashish; Godlaveti, Vijaya Narasimha Kumar; Gupta, Pankaj

doi:10.36468/pharmaceutical-sciences.847

Cited by 2 publications

(1 citation statement)

References 24 publications

(22 reference statements)

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“…There is a need to assure the safety and quality of homoeopathic medicines especially which are toxic in nature, at the international, national, and regional levels (Organization, 2009; Manchanda, 2018). There are very few literature available regarding the safety of homeopathic medicines (Sharma et al, 2021a;Sharma et al, 2022b;Kirby 2002).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological investigation on acute and sub-acute studies of Arsenicum album in Experimental Rats

Lal

Sharma

Behera

et al. 2022

Preprint

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Purpose Arsenic album in its various potencies are frequently prescribed by homoeopathic practitioners for wide range of human anomaly in everyday life. However, reports on safety and effects of Arsenic album are not available till date to support its usage. Therefore the objective of study is to evaluate the acute and subacute oral toxicity of Arsenic albumin 6C, 30C and 200C in experimental rats. Materials and Methods Arsenic album (6C, 30C, 200C) was administered orally at 2000 µl/kg to access acute toxicity in Wistar rats and observed for toxic signs up to 14 days. For subacute oral toxicity study, it was administered for 28 days. Animals were observed for clinical signs, change in body weights, feed intake and water intake. Hematological, biochemical, organ weight, histopathological analysis were assessed. Results No mortality at a dose of 2000 µl/kg of Arsenic album in acute toxicity study, which indicates that oral LD50 of arsenic album (6C, 30C, 200C) is > 2000 µl/kg. In subacute toxicity study, Arsenic album (6C, 30C, 200C) orally at 200 µl/kg did not show any significant changes in body weight, feed consumption, water intake, hematological and biochemical parameters compared to normal group. Furthermore, no pathological changes were observed in histopathology of treated rats compared to normal group. Conclusion Collectively, results suggest that the Arsenic album (6C, 30C, 200C) is safe and produces no toxicity when administered for prolonged duration at 200 µl/kg in Wistar albino rats.

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Section: Introductionmentioning

confidence: 99%

Pharmacological investigation on acute and sub-acute studies of Arsenicum album in Experimental Rats

Lal

Sharma

Behera

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Safety Evaluation of Arsenicum album in Acute and Sub-Acute Toxicity Studies in Rats

Lal

Sharma

Behera

et al. 2023

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Arsenic album is frequently prescribed in homoeopathy for many diseases. However, its safety data is not available. Thus, the study’s purpose is to evaluate the oral toxicity of Arsenic album 6C, 30C, and 200C in rats. Arsenic album (6C, 30C, and 200C) was given at 2000 μl/kg for acute toxicity and observed for up to 14 days. For subacute toxicity, it was given for 28 days and observed for clinical signs, change in body weight and Mortality. Hematological, biochemical, organ weight and histopathological analyses were assessed. Results indicate no mortality of arsenic album in acute toxicity and LD50 is >2000 μl/kg. In the subacute toxicity study, arsenic album (200 μl/kg) did not show any significant changes in above parameters. It may be concluded that the arsenic album (6C, 30C, and 200C) is safe and produces no toxicity when administered orally for a prolonged duration at 200 μl/kg in rats.

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Effect of Acute Exposure of Belladonna Mother Tincture on Zebrafish Embryonic Development

Cited by 2 publications

References 24 publications

Pharmacological investigation on acute and sub-acute studies of Arsenicum album in Experimental Rats

Pharmacological investigation on acute and sub-acute studies of Arsenicum album in Experimental Rats

Safety Evaluation of Arsenicum album in Acute and Sub-Acute Toxicity Studies in Rats

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