Effect of acute gouty arthritis on sleep patterns: A preclinical study

Guevara-López, Uriah; Ayala‐Guerrero, Fructuoso; Covarrubias-Gómez, Alfredo; López‐Muñoz, Francisco; Torres-González, R

doi:10.1016/j.ejpain.2008.04.002

Cited by 16 publications

(11 citation statements)

References 75 publications

(113 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study confirmed a causal relationship between sleep disturbance and pain in control animals, as evidenced by an increase in AW time and decreases in QS and PS times. This is consistent with the findings of previous studies on the effects of pain on sleep [39][40][41] . We applied telemetric recording without interruption of rat activity for 24 h and differentiated between the light (resting) and dark (active) phases.…”

Section: Discussionsupporting

confidence: 83%

Changes in Sleep Architecture under Sustained Pain in Adult Male Rats Subjected to Neonatal Short-Lasting Local Inflammatory Insult

et al. 2017

View full text Add to dashboard Cite

Neonatal, short-lasting, local, nociceptive insult by carrageenan can cause long-term alterations in somatosensory and neurohumoral systems. We previously revealed hyporesponsiveness of the autonomic nervous system (ANS) after painful stimulation of adult rats in a neonatal carrageenan-induced pain model. Sleep disturbance has been highly correlated with pain and ANS activity. In the present study, adult rats that had received an intraplantar injection of carrageenan on postnatal day 1 were investigated to determine if there were alterations in their sleep architecture upon the stimulation of pain. Polysomnographic and heart rate variability recordings were carried out, with a wireless transmission of data, for 24 h under baseline conditions and after an intraplantar injection of complete Freund's adjuvant to induce sustained nociception. Increased active awake (AW) and decreased quiet sleep (QS) and paradoxical sleep (PS) times were noted in the control animals. In the carrageenan-treated rats, the AW time increased but with decreased alertness, as revealed by decreases in beta and increases in theta power. The QS time did not decrease. The PS time decreased during the first 12 h, then increased during the following 12 h, suggesting an early rebound of formerly deprived PS time. Sympathetic activation under sustained pain was not apparent in any stage of sleep in carrageenan-treated rats and was even suppressed in AW time. An impaired sympathetic reaction to pain may have contributed to the atypical changes in sleep architecture in these rats. In conclusion, pain in early life has a long-term effect on the cardiovascular-autonomic-electroencephalographic responses to pain later in life. The physiological relevance of these results remains undetermined.

show abstract

Section: Discussionsupporting

confidence: 83%

Changes in Sleep Architecture under Sustained Pain in Adult Male Rats Subjected to Neonatal Short-Lasting Local Inflammatory Insult

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Gout patients described sleep disruption, with problems falling asleep and gout flares waking them up. A recent clinical study showing an independent association of gout with sleep problems [43] and a pre-clinical study showing altered rapid eye movement sleep and total sleep time after an intra-articular injection of uric acid [44] are highly supportive. Sleep disturbances are common in rheumatoid arthritis [45,46], another inflammatory arthritis, and respond to treatment with disease-modifying agents that target cytokines [47].…”

Section: Discussionmentioning

confidence: 99%

The impact of gout on patient’s lives: a study of African-American and Caucasian men and women with gout

Singh

2014

Arthritis Res Ther

View full text Add to dashboard Cite

IntroductionThe aim of this study was to examine the impact of gout on quality of life (QOL) and study differences by gender and race.MethodsTen race- and sex-stratified nominal groups were conducted, oversampling for African-Americans and women with gout. Patients presented, discussed, combined and rank-ordered their concerns.ResultsA total of 62 patients with mean age 65.1 years, 60% men, 64% African-American, participated in 10 nominal groups: African-American men (n = 23; 3 groups); African-American women (n = 18; 3 groups); Caucasian men (n = 15; 3 groups); and Caucasian women (n = 6; 1 group). The most frequently cited high-ranked concerns among the ten nominal groups were: (1) effect of gout flare on daily activities (n = 10 groups); (2) work disability (n = 8 groups); (3) severe pain (n = 8 groups); (4) joint swelling and tenderness (n = 6 groups); (5) food restrictions (n = 6 groups); (6) medication related issues (n = 6 groups); (7) dependency on family and others (n = 5 groups); (8) emotional Impact (n = 5 groups); (9) interference with sexual function (n = 4 groups); (10) difficulty with shoes (n = 4 groups); and (11) sleep disruption (n = 4 groups). Compared with men, women ranked the following concerns high more often: problems with shoes (n = 4 versus n = 0 groups); dependency (n = 3 versus n = 2 groups); and joint/limb deformity (n = 2 versus n = 0 group). Compared with Caucasians, African-Americans ranked the following concerns high more often: dietary restrictions (n = 6 versus n = 0 groups); severe pain (n = 6 versus n = 2 groups); gout bringing the day to a “halt” (n = 2 versus n = 0 group); effect on emotional health (n = 4 versus n = 1 groups); and the need for canes/crutches during flares (n = 2 versus n = 0 group).ConclusionsGout has a significant impact on a patient’s QOL. Important differences in the impact of gout by gender and race were noted.

show abstract

“…First, we cannot directly measure sleep, disruption of which is an often-reported problem in chronic pain patients [48] and has been observed in some studies of rats with nerve injury or experimental arthritis [15,28,40,60]. By documenting periods and patterns of inactivity, the HCM system can, to some extent, provide a reasonable estimate of sleep.…”

Section: Discussionmentioning

confidence: 99%

“…Further, if the animal is indeed experiencing spontaneous pain similar to humans, there should be an impact on its daily life activity and affective state, behaviors we will herein refer to as “quality of life” measures. To date, such studies in rodents have concentrated on the rat and included measures of daily life such as sleep [15,24,28,40,55,60] and locomotion [6,16,27,33,61]. Results from these and other studies on affective state changes following chronic injury are mixed.…”

Section: Introductionmentioning

confidence: 99%

Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity

Urban

Scherrer

Goulding

et al. 2011

Pain

159

180

View full text Add to dashboard Cite

Despite the impact of chronic pain on the quality of life in patients, including changes to affective state and daily life activities, rodent preclinical models rarely address this aspect of chronic pain. To better understand the behavioral consequences of the tissue and nerve injuries typically used to model neuropathic and inflammatory pain in mice, we measured home cage and affective state behaviors in animals with spared nerve injury (SNI), chronic constriction injury (CCI) or intraplantar CFA. Mechanical hypersensitivity is prominent in each of these conditions and persists for many weeks. Home cage behavior was continuously monitored for 16 days in a system that measures locomotion, feeding and drinking and allows for precise analysis of circadian patterns. When monitored after injury, animals with SNI and CFA behaved no differently from controls in any aspect of daily life. Animals with CCI were initially less active, but the difference between CCI and controls disappeared by 2 weeks after injury. Further, in all pain models, there was no change in any measure of affective state. We conclude that in these standard models of persistent pain, despite the development of prolonged hypersensitivity, the mice do not have significantly altered "quality of life". As alteration in daily life activities is the feature that is so disrupted in patients with chronic pain, our results suggest that the models used here do not fully reflect the human conditions and point to a need for development of a murine chronic pain model in which lifestyle changes are manifest.

show abstract

Effect of acute gouty arthritis on sleep patterns: A preclinical study

Abstract: These data suggest that a nociceptive stimulus, induced by the intra-articular administration of uric acid, alters the sleep-wake equilibrium with REM sleep being particularly altered. However, further research concerning pain-sleep interaction is needed.

Cited by 16 publications

References 75 publications

Changes in Sleep Architecture under Sustained Pain in Adult Male Rats Subjected to Neonatal Short-Lasting Local Inflammatory Insult

Changes in Sleep Architecture under Sustained Pain in Adult Male Rats Subjected to Neonatal Short-Lasting Local Inflammatory Insult

The impact of gout on patient’s lives: a study of African-American and Caucasian men and women with gout

Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity

Contact Info

Product

Resources

About