Effect of Acute Hypoxia on Maximal Exercise in Trained and Sedentary Women

Woorons, Xavier; Mollard, Pascal; Lamberto, Christine; Letournel, Muriel; Richalet, Jean‐Paul

doi:10.1249/01.mss.0000150020.25153.34

Cited by 49 publications

(53 citation statements)

References 32 publications

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“…However, this hypothesis is controversial (Brooks 1991;Katz and Sahlin 1988). A more relevant hypothesis could be that the relative exercise intensity was greater during VH 0.21 than NB 0.21 since _ VO 2max decreases in the presence of arterial O 2 desaturation, especially in trained subjects (Bourdillon et al 2009a;Mollard et al 2007;Woorons et al 2005). Anyway, irrespective of the reasons leading to a greater metabolic acidosis during exercise with VH, this phenomenon is interesting since it reflects a higher solicitation of anaerobic glycolysis.…”

Section: Discussionmentioning

confidence: 99%

Exercise with hypoventilation induces lower muscle oxygenation and higher blood lactate concentration: role of hypoxia and hypercapnia

et al. 2010

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Eight men performed three series of 5-min exercise on a cycle ergometer at 65% of normoxic maximal O(2) consumption in four conditions: (1) voluntary hypoventilation (VH) in normoxia (VH(0.21)), (2) VH in hyperoxia (inducing hypercapnia) (inspired oxygen fraction [F(I)O(2)] = 0.29; VH(0.29)), (3) normal breathing (NB) in hypoxia (F(I)O(2) = 0.157; NB(0.157)), (4) NB in normoxia (NB(0.21)). Using near-infrared spectroscopy, changes in concentration of oxy-(Delta[O(2)Hb]) and deoxyhemoglobin (Delta[HHb]) were measured in the vastus lateralis muscle. Delta[O(2)Hb - HHb] and Delta[O(2)Hb + HHb] were calculated and used as oxygenation index and change in regional blood volume, respectively. Earlobe blood samples were taken throughout the exercise. Both VH(0.21) and NB(0.157) induced a severe and similar hypoxemia (arterial oxygen saturation [SaO(2)] < 88%) whereas SaO(2) remained above 94% and was not different between VH(0.29) and NB(0.21). Arterialized O(2) and CO(2) pressures as well as P50 were higher and pH lower in VH(0.21) than in NB(0.157), and in VH(0.29) than in NB(0.21). Delta[O(2)Hb] and Delta[O(2)Hb - HHb] were lower and Delta[HHb] higher at the end of each series in both VH(0.21) and NB(0.157) than in NB(0.21) and VH(0.29). There was no difference in Delta[O(2)Hb + HHb] between testing conditions. [La] in VH(0.21) was greater than both in NB(0.21) and VH(0.29) but not different from NB(0.157). This study demonstrated that exercise with VH induced a lower tissue oxygenation and a higher [La] than exercise with NB. This was caused by a severe arterial O(2) desaturation induced by both hypoxic and hypercapnic effects.

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Section: Discussionmentioning

confidence: 99%

Exercise with hypoventilation induces lower muscle oxygenation and higher blood lactate concentration: role of hypoxia and hypercapnia

et al. 2010

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“…This can be explained by the maintenance of a high arterial desaturation that is produced by the limited diffusion [21].…”

Section: Hematological Parametersmentioning

confidence: 99%

Biochemical and functional modifications in biathlon athletes at medium altitude training / Modificările biochimice și funcționale ale atleților biatloniști după antrenament la altitudine medie

Bădău

Bacârea

Ungur

et al. 2016

Revista Romana De Medicina De Laborator

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Objective: The aim of our research was to identify physiological and biochemical changes induced by training at medium altitude. Methods: Ten biathlon athletes underwent 28-day training camp at medium altitude in order to improve their aerobic effort, following the living high-base train high-interval train low (Hi-Hi-Lo) protocol. There were investigated three categories of functional and biochemical parameters, targeting the hematological changes (RBC, HCT, HGB), the oxidative (lipoperoxid, free malondialdehyde and total malondialdehyde) and antioxidative balance (the hydrogen donor capacity, ceruloplasmin and uric acid) and the capacity of effort (the maximum aerobic power, the cardiovascular economy in effort, the maximum O2 consumption). Results: All the biochemical and functional evaluated parameters showed significant increases between the pre-training testing and post-training testing (5.13 ± 0.11 vs. 6.50 ± 0.09, p < 0.0001 for RBC; 44.80 ± 1.22 vs. 51.31 ± 2.31, p < 0.0001 for HCT; 15.06 ± 0.33 vs. 17.14 ± 0.25, p < 0.0001 for HGB; 1.32 ± 0.04 vs.1.62 ± 0.01, p < 0.0001 for LPx; 1.61 ± 0.01 vs. 1.73 ± 0.01, p < 0.0001 for free MDA; 2.98 ± 0.08 vs. 3.37 ± 0.03, p < 0.0001 for total MDA; 45.92 ± 0.13 vs. 57.98 ± 0.12, p < 0.0001 for HD; 25.95 ± 0.13 vs. 31.04 ± 0.06, p < 0.0001 for Crp; 3.47 ± 0.03 vs.7.69 ± 0.02, p < 0.0001 for UA; 63.91 ± 1.00 vs. 81.53 ± 1.97, p < 0.0001 for MAP; 33.13 ± 0.57 vs. 57.41 ± 0.63, p < 0.0001 for CVEE; 4190 ± 50.45 vs. 5945 ± 46.48, p < 0.0001 p < 0.0001 for RBC; 44.80 ± 1.22 vs. 51.31 ± 2.31, p < 0.0001 for HCT; 15.06 ± 0.33 vs. 17.14 ± 0.25, p < 0.0001 for HGB; 1.32 ± 0.04 vs.1.62 ± 0.01, p < 0.0001 for LPx; 1.61 ± 0.01 vs. 1.73 ± 0.01, p < 0.0001 for free MDA; 2.98 ± 0.08 vs. 3.37 ± 0.03, p < 0.0001 for total MDA; 45.92 ± 0.13 vs. 57.98 ± 0.12, p < 0.0001 for HD; 25.95 ± 0.13 vs. 31.04 ± 0.06, p < 0.0001 for Crp; 3.47 ± 0.03 vs.7.69 ± 0.02, p < 0.0001 for UA; 63.91 ± 1.00 vs. 81.53 ± 1.97, p < 0.0001 for MAP; 33.13 ± 0.57 vs. 57.41 ± 0.63, p < 0.0001 for CVEE; 4190 ± 50.45 vs. 5945 ± 46.48, p < 0.0001

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“…Oxygen saturation (SaO 2 ) was estimated by an ear oximeter (Nonin, 8000Q, Plymouth, Minn, USA) at sea level and at an altitude of 3,900 m after 10 min of quiet sitting (Cymerman et al 1989;Woorons et al 2005). For technical reasons, SaO 2 was not measured at the summit.…”

Section: Estimation Of _mentioning

confidence: 99%

Mountaineering experience decreases the net oxygen cost of climbing Mont Blanc (4,808 m)

Billat

Dupré

Karp³

et al. 2009

Eur J Appl Physiol

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The purpose of this study was to test the hypothesis that mountaineering experience decreases the net oxygen cost of uphill walking (OCw) on steep mountain trails and in ice and snow conditions. OCw was measured during an ascent of Mont Blanc in eight experienced alpinists and eight non-alpinists who were matched for sex (4 + 4) and low-altitude aerobic power (V(O)(2)(max) 50-55 ml kg(-1) min(-1)). Subjects carried a breath-by-breath gas exchange analyzer and a GPS. V(O)(2)(max) at altitude was estimated from measured low-altitude V(O)(2)(max) using Bassett's equation to calculate fractional use of V(O)(2)(max) during the ascent (FV(O)(2)(max)). OCw was calculated as the difference between V(O)(2) while climbing minus resting V(O)(2). At all elevations, Alpinists exhibited a lower OCw (P < 0.01). In all subjects, OCw increased when encountering ice and snow conditions. FV(O)(2)(max) remained stable around 75% at all elevations independent of experience or sex. In conclusion, the OCw is lower in experienced mountaineers compared to non-experienced subjects, and increases when going from steep rocky mountain terrain to ice and snow conditions, independent of mountaineering experience or sex.

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Effect of Acute Hypoxia on Maximal Exercise in Trained and Sedentary Women

Abstract: These results demonstrate that endurance-trained women show a greater decrement in VO(2max) at high altitudes. This could be explained mainly by a higher arterial desaturation, which is largely caused, according to our results, by diffusion limitation.

Cited by 49 publications

References 32 publications

Exercise with hypoventilation induces lower muscle oxygenation and higher blood lactate concentration: role of hypoxia and hypercapnia

Exercise with hypoventilation induces lower muscle oxygenation and higher blood lactate concentration: role of hypoxia and hypercapnia

Biochemical and functional modifications in biathlon athletes at medium altitude training / Modificările biochimice și funcționale ale atleților biatloniști după antrenament la altitudine medie

Mountaineering experience decreases the net oxygen cost of climbing Mont Blanc (4,808 m)

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