Effect of Acute Physical Exercise on Lymphocyte Subpopulations in Trained and Untrained Subjects

Oshida, Yoshiharu; Yamanouchi, Kunio; Hayamizu, Sayoko; Sato, Yuki

doi:10.1055/s-2007-1024995

Cited by 87 publications

(47 citation statements)

References 10 publications

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“…The above-mentioned studies and in addition the studies by Papa et al (1989) and Oshida et al (1988) have shown that the lymphocyte proliferative response is either decreased (Papa et al 1989), elevated (Baj et al 1994;Nieman et al 1993) or in most studies unchanged (Nieman et al 1995a,b;Oshida et al 1988;Tvede et al 1991) when results are compared between trained and less trained subjects. To our knowledge no studies have demonstrated that the proliferative response to acute exercise differs between trained and untrained subjects.…”

Section: Trained Versus Nontrained Subjectsmentioning

confidence: 91%

Lymphocyte proliferation in response to exercise

Nielsen

Pedersen

1997

European Journal of Applied Physiology

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Lymphocyte proliferative responses are often used to evaluate the functional capacity of the immune system in response to exercise. Blood mononuclear cells (BMNC) are stimulated in vitro with polyclonal mitogens and the incorporation of 3H-thymidine into the DNA reflects cell proliferation. The BMNC are most often stimulated with either phytohaemagglutinin (PHA), poke weed mitogen (PWM), concanavalin A (Con-A), interleukin-2 (IL-2), or purified derivative of tuberculin (PPD). The literature concerning lymphocyte proliferation and exercise is reviewed with respect to the type and intensity of exercise, and also the effect of training status. The proliferative responses to exercise are highly heterogeneous, the most consistent finding being that PHA-stimulated cell responses decrease during exercise which may reflect a decreased fraction of CD3+ cells. In contrast, reduced, elevated or even unchanged lymphocyte proliferative response to PHA, PWM, Con-A, IL-2 and PPD have been demonstrated in the recovery period following exercise. Also variable responses are present in trained athletes compared to less fit subjects. Even though this may reflect that the time of 3H-thymidine incorporation into lymphocytes varies, we conclude that a functional evaluation of the immune system in response to exercise cannot be based solely upon measurements of lymphocyte proliferation.

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Section: Trained Versus Nontrained Subjectsmentioning

confidence: 91%

Lymphocyte proliferation in response to exercise

Nielsen

Pedersen

1997

European Journal of Applied Physiology

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“…The concentration of all lymphocyte subpopulations increases in the vascular compartment during exercise and decreases to levels lower than those presented in the pre-exercise period after long duration physical work 70,71 . During exercise, the CD4+ :CD8+ ratio decreases, reflecting a more remarkable increase in the TCD8+ cells in comparison to the TCD4+ 26 .…”

Section: Subpopulations Of Lymphocytesmentioning

confidence: 99%

Efeito do exercício no sistema imune: resposta, adaptação e sinalização celular

Terra

Da-Silva

Salerno

et al. 2012

Rev Bras Med Esporte

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Introduction: Over the last century, people have become less active, adopting more sedentary habits. This scenario has increased the incidence of chronic diseases such as cardiovascular diseases, type 2 diabetes and metabolic syndrome. The practice of physical activities can influence healthiness by altering the metabolic state and also the immune system. Objective: To review the literature for studies that address the effects promoted by physical exercise on the development of immune responses and the possible signal transduction pathways. Methods: The SciELO and PubMed data bases were consulted. Results: The available literature shows that during the practice of exercise, various subpopulations of leukocytes are altered in accordance with the intensity and duration of the activity performed. Exercise of moderate intensity stimulates a pro-inflammatory response, while those of high intensity tend to promote antiinflammatory responses that could decrease damage to skeletal muscle. Such alterations are observed in cells that present antigens (such as macrophages and dendritic cells), neutrophils, natural killer cells (NK) and in surface molecules like Toll-like receptors (TLR) and major histocompatibility complex class II, as well as the entire repertoire of cytokines. Conclusion: The current state of knowledge suggests that the alterations in the immune system are dependent on parameters inherent to exercise and that in order to have all these alterations occurring, some cell signaling cascades are activated, giving rise to a complex process of phosphorylation/dephosphorylation that culminates in the activation of transcription factors, translation of mRNA's, protein synthesis and cell proliferation.

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“…subsequent to moderate or high-fit bicycle ergometer exercise [6][7][8][9], Also under these condi tions the number of total mononucleated cells increased and that of CD3+ and CD4+ cells decreased. The higher the intensity of work the greater the impact on the number of T lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

Changes in White Blood Cells during Parturition in Mothers and Newborn

Delgado¹,

Neubert

Dudenhausen

1994

Gynecol Obstet Invest

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Following spontaneous delivery (n = 12) a pronounced increase in the maternal total white blood cell count was found (to [X ± SD]: 20 ± 6 × 10⁹ total leukocytes/1), which would be considered highly ‘pathological’ in nonpregnant women. The alteration was predominantly due to an increase in polymorph-nuclear cells and band forms. Simultaneously, a drastic decrease in the percentage and the absolute number of lymphocytes was noticed in venous blood (from 32 to 5%, or [X ± SD]: from 2.7 ± 0.7 to 1.1 ± 0.3 × 10⁹ total lymphocytes/1). In this decrease nearly all lymphocyte subtypes were involved, although to differing extents. Following elective caesarean delivery (n = 6), no leukocytosis was found, however the percentage and absolute number of lymphocytes was also decreased, although not as pronounced as after spontaneous delivery. Again not all the lymphocyte subpopulations were affected to the same degree, and the effect was especially obvious for the suppressor T cells and B cells. Following emergency caesarean delivery (n = 5), no obvious effect on the absolute number of lymphocytes or on the pattern of lymphocyte sub-populations was observed. However, the total number of white blood cells was clearly increased, as after spontaneous deliveries. The possible significance of these findings, also for therapeutic consequences during the perinatal period, is discussed.

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Effect of Acute Physical Exercise on Lymphocyte Subpopulations in Trained and Untrained Subjects

Cited by 87 publications

References 10 publications

Lymphocyte proliferation in response to exercise

Lymphocyte proliferation in response to exercise

Efeito do exercício no sistema imune: resposta, adaptação e sinalização celular

Changes in White Blood Cells during Parturition in Mothers and Newborn

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