2018
DOI: 10.3389/fphys.2018.00677
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Effect of Acute, Subacute, and Repeated Exposure to High Altitude (5050 m) on Psychomotor Vigilance

Abstract: Aim: High altitude (HA) hypoxia may affect cognitive performance and sleep quality. Further, vigilance is reduced following sleep deprivation. We investigated the effect on vigilance, actigraphic sleep indices, and their relationships with acute mountain sickness (AMS) during very HA exposure, acclimatization, and re-exposure.Methods: A total of 21 healthy altitude-naive individuals (25 ± 4 years; 13 females) completed 2 cycles of altitude exposure separated by 7 days at low altitude (LA, 520 m). Participants … Show more

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Cited by 34 publications
(46 citation statements)
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“…These findings are consistent with previous studies that demonstrate how cognitive performance at high altitude improves with acclimatization, but these effects do not carry over upon re-ascent after a week of rest at low altitude (Subudhi et al, 2014;Pun et al, 2018a). This is opposite to the mechanisms that regulate other physiological parameters and susceptibility to acute mountain sickness (Pun et al, 2018b). It is not entirely clear why cognitive acclimatization does not follow a similar pattern as physiological acclimatization.…”
Section: Discussionsupporting
confidence: 90%
See 1 more Smart Citation
“…These findings are consistent with previous studies that demonstrate how cognitive performance at high altitude improves with acclimatization, but these effects do not carry over upon re-ascent after a week of rest at low altitude (Subudhi et al, 2014;Pun et al, 2018a). This is opposite to the mechanisms that regulate other physiological parameters and susceptibility to acute mountain sickness (Pun et al, 2018b). It is not entirely clear why cognitive acclimatization does not follow a similar pattern as physiological acclimatization.…”
Section: Discussionsupporting
confidence: 90%
“…Previous studies have shown that acute exposure to very high altitude (5050 m) leads to profound hypoxemia (near sea level SpO 2 : 98.0% -0.9% to altitude SpO 2 : 80.2% -4.7%), which improves with acclimatization over a week (SpO 2 at 5050 m: 83.7% -4.5%), although individuals tend to remain significantly hypoxemic when compared to sea level measurements (Pun et al, 2018b). The acute hypoxemia associated with brain tissue hypoxia at these altitudes can adversely affect cognitive function such as attention (Limmer and Platen, 2018;Pun et al, 2018a), executive functions (Asmaro et al, 2013;Ochi et al, 2018a, b), information processing (Davranche et al, 2016), and memory (Kramer et al, 1993).…”
Section: Introductionmentioning
confidence: 98%
“…Therefore, cognitive impairment to tasks involving sustained attention (i.e. tasks involving reaction time) often occur during the initial exposure to high altitude (4350 m and 5050 m), but are reversed within the days following acclimatization (Davranche et al., ; Pun et al., ).…”
Section: Discussionmentioning
confidence: 99%
“…Most of the literature focuses on acclimatization, mainly from very high-altitude mountain expeditions. Recent literature examined cognitive function after acute, subacute and repeated exposure to high altitude (Pun et al, 2018a, b). These studies showed: (1) that acute exposure decreased psychomotor vigilance whereas a 6-day acclimatization prevented impairments during subsequent re-exposure (Pun et al, 2018b); (2) that attention was impaired at high-altitude but improved after acclimatization (Pun et al, 2018a).…”
Section: Discussionmentioning
confidence: 99%
“…Many studies have investigated cognitive performances after night acclimatization (Pun et al, 2018b) subacute or repeated exposure to high altitude (Pun et al, 2018a). Most showed a certain degree of cognitive impairment.…”
Section: Introductionmentioning
confidence: 99%