Effect of acyclovir, ganciclovir and cidofovir on equid herpesvirus 3 in vitro

Vissani, A.; Tordoya, S.; Becerra, L.; Thiry, Étienne; Barrandeguy, M.

doi:10.1016/j.jevs.2012.08.167

Journal of Equine Veterinary Science

2012

DOI: 10.1016/j.jevs.2012.08.167

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Effect of acyclovir, ganciclovir and cidofovir on equid herpesvirus 3 in vitro

A. Vissani¹,

S. Tordoya²,

L. Becerra³

et al.

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2018

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“…The acyclovir was also found to have antiviral activity in vitro against Feline herpesvirus 1 (FHV-1) in Crandell-Rees feline kidney (CRFK) cells (van der Meulen, Garré, Croubels, & Nauwynck, 2006), against Bovine herpesvirus type 1 (BHV-1) and Caprine herpesvirus 1 (CpHV-1) in Madin-Darby Bovine Kidney (MDBK) cells (Camero et al, 2017;Elia et al, 2015;Enan, Abdallah, & Sobhy, 2012) as well as against Equid herpesvirus 3 (EHV-3) in Ederm cells (Vissani, Tordoya, Becerra, Thiry, & Barrandeguy, 2012). Some of the in vitro findings were verified in vivo mainly by means of valacyclovir (valACV).…”

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confidence: 99%

Acyclovir inhibits Cyprinid herpesvirus 3 multiplication in vitro

Troszok

Kolek

Szczygieł

et al. 2018

Journal of Fish Diseases

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Cyprinid herpesvirus 3 (CyHV-3), also known as koi herpesvirus (KHV), is an aetiological agent of a virulent and lethal disease in common and koi carp. In this study, we examined in vitro the anti-CyHV-3 activity of acyclovir (ACV), nucleoside analogue commonly used against human herpesviruses, as well as acyclovir monophospate (ACV-MP). The cytotoxicity of the ACV and the ACV-MP for two common carp cell lines, CCB (Common carp brain) and KF1 (Koi carp fin 1), was determined by means of MTT and crystal violet assays. In subsequent studies, the concentration of 66.67 μM was applied. The ACV and the ACV-MP (66.67 μM) inhibited a cytopathic effect (CPE) induced by the CyHV-3 virus in the CCB (ACV by 66%, ACV-MP by 58%) and the KF1 (ACV by 25%, ACV-MP by 37%). The viral load measured by the means of TaqMan qPCR was reduced in a range of 67%-93% depending on the analogue, the cell line and the time of incubation. The expression of viral genes (ORF149, ORF3, ORF134 and ORF78) in CCB cells infected with the CyHV-3 was strongly downregulated within the range of 78%-91%. In summary, both the ACV and the ACV-MP can inhibit CyHV-3 replication in vitro.

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mentioning

confidence: 99%

Acyclovir inhibits Cyprinid herpesvirus 3 multiplication in vitro

Troszok

Kolek

Szczygieł

et al. 2018

Journal of Fish Diseases

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Effect of acyclovir, ganciclovir and cidofovir on equid herpesvirus 3 in vitro

Cited by 1 publication

References 3 publications

Acyclovir inhibits Cyprinid herpesvirus 3 multiplication in vitro

Acyclovir inhibits Cyprinid herpesvirus 3 multiplication in vitro

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