Effect of adding the herb Achillea millefolium on mouthwash on chemotherapy induced oral mucositis in cancer patients: A double-blind randomized controlled trial

Miranzadeh, Sedigheh; Adib-Hajbaghery, Mohsen; Soleymanpoor, Leyla; Ehsani, Majid

doi:10.1016/j.ejon.2014.10.019

Cited by 41 publications

(27 citation statements)

References 23 publications

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“…Miranzadeh et al () investigated the effect of A. millefolium distillate solution in the treatment of chemotherapy‐induced oral mucositis (OM) in 56 cancer patients. The experimental group gargled 15 mL of a mixture of routine solution and distilled A. millefolium 4 times a day for 14 days, while the control group gargled 15 mL of routine solution.…”

Section: Clinical Datamentioning

confidence: 99%

Pharmacognosy, Phytochemistry and Pharmacological Properties ofAchillea millefoliumL.: A Review

2017

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Achillea millefoilum L. (Yarrow) is an important species of Asteraceae family with common utilization in traditional medicine of several cultures from Europe to Asia for the treatment of spasmodic gastrointestinal disorders, hepatobiliary, gynecological disorders, against inflammation and for wound healing. An extensive review of literature was made on A. millefoilum L. using ethno botanical text books, published articles in peer-reviewed journals, unpublished materials and scientific databases. The Plant List, International Plant Name Index and Kew Botanical Garden databases were used to authenticate the scientific names. Monoterpenes are the most representative metabolites constituting 90% of the essential oils in relation to the sesquiterpenes, and a wide range of chemical compounds have also been reported. Different pharmacological experiments in many in-vitro and in-vivo models have proved the potential of A. millefoilum with antiinflammatory, antiulcer, anticancer activities etc. lending support to the rationale behind numerous of its traditional uses. Due to the noteworthy pharmacological activities, A. millefoilum will be a better option for new drug discovery. The present review will comprehensively summarize the pharmacognosy, phytochemistry and ethnopharmacology of A. millefoilum reported to date, with emphasis on more in vitro, clinical and pathological studies needed to investigate the unexploited potential of this plant. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Clinical Datamentioning

confidence: 99%

Pharmacognosy, Phytochemistry and Pharmacological Properties ofAchillea millefoliumL.: A Review

2017

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“…Its sedative properties were also described, since recent studies have shown that a hydroalcoholic extract of A. millefolium has anxiolytic effects in vivo (Baretta et al, 2012). In addition, this plant can be used in a distillate solution as a disinfectant due to its antibacterial effect (Miranzadeh et al, 2015). Interestingly, some studies showed the antitumor potential of some extracts of A. millefolium in human tumor cell lines (Csupor-Loffler et al, 2009;Dias et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Achillea millefolium L. hydroethanolic extract inhibits growth of human tumor cell lines by interfering with cell cycle and inducing apoptosis

Pereira¹,

Peixoto

Teixeira

et al. 2018

Food and Chemical Toxicology

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The cell growth inhibitory activity of the hydroethanolic extract of Achillea millefolium was studied in human tumor cell lines (NCI-H460 and HCT-15) and its mechanism of action was investigated. The GI concentration was determined with the sulforhodamine B assay and cell cycle and apoptosis were analyzed by flow cytometry following incubation with PI or Annexin V FITC/PI, respectively. The expression levels of proteins involved in cell cycle and apoptosis were analyzed by Western blot. The extracts were characterized regarding their phenolic composition by LC-DAD-ESI/MS. 3,5-O-Dicaffeoylquinic acid, followed by 5-O-caffeoylquinic acid, were the main phenolic acids, while, luteolin-O-acetylhexoside and apigenin-O-acetylhexoside were the main flavonoids. This extract decreased the growth of the tested cell lines, being more potent in HCT-15 and then in NCI-H460 cells. Two different concentrations of the extract (75 and 100 μg/mL) caused alterations in cell cycle profile and increased apoptosis levels in HCT-15 and NCI-H460 cells. Moreover, the extract caused an increase in p53 and p21 expression in NCI-H460 cells (which have wt p53), and reduced XIAP levels in HCT-15 cells (with mutant p53). This work enhances the importance of A. millefolium as source of bioactive phenolic compounds, particularly of XIAP inhibitors.

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“…In recent years, more attention has been focused on the role of natural drugs. 8 These "natural substances" are low-molecular weight organic compounds found in plants that activate a defence system against physiological and/or environmental stress. [9][10][11] Such compounds have antioxidant, antimicrobial, and immunomodulatory properties and derive from secondary metabolites, which belong mainly to the category of terpenes, terpenoids, alkaloids, phenols, and flavonoids.…”

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Efficacy of a Solution Composed by Verbascoside, Polyvinylpyrrolidone (PVP) and Sodium Hyaluronate in the Treatment of Chemotherapy-induced Oral Mucositis in Children With Acute Lymphoblastic Leukemia

Bardellini

Amadori

Schumacher

et al. 2016

Journal of Pediatric Hematology/Oncology

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Summary: The aim of this study was to assess the efficacy of a solution composed by verbascoside, polyvinylpyrrolidone, and sodium hyaluronate (Mucosyte) in the treatment of chemotherapyinduced oral mucositi (OM). Patients between 5 and 18 years receiving chemotherapy for acute lymphoblastic leukemia and with OM grade 1 or 2 were randomized in group A (treated with Mucosyte, 3 mouthwashes/d per 8 d) and group B (treated with placebo, ie, an inert water-based solution, 3 mouthwashes/d per 8 d). The OM scoring was performed at day 1 (diagnosis of OM-T0), after 3 days of treatment (T1), and at day 8 (T2). Pain was evaluated through the visual analog scale with the same timing of OM measurement. A total of 56 patients were included (28 patients per group). Group A experienced a statistically significant decline of OM at T2 (P = 0.0038); a statistically significant difference in pain reduction between 2 groups both at T1 and at T2 (P < 0.005) was observed. The use of Mucosyte mouthwashes in children with chemotherapy-induced OM may be recommended as supportive therapy.

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Effect of adding the herb Achillea millefolium on mouthwash on chemotherapy induced oral mucositis in cancer patients: A double-blind randomized controlled trial

Cited by 41 publications

References 23 publications

Pharmacognosy, Phytochemistry and Pharmacological Properties ofAchillea millefoliumL.: A Review

Pharmacognosy, Phytochemistry and Pharmacological Properties ofAchillea millefoliumL.: A Review

Achillea millefolium L. hydroethanolic extract inhibits growth of human tumor cell lines by interfering with cell cycle and inducing apoptosis

Efficacy of a Solution Composed by Verbascoside, Polyvinylpyrrolidone (PVP) and Sodium Hyaluronate in the Treatment of Chemotherapy-induced Oral Mucositis in Children With Acute Lymphoblastic Leukemia

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