Effect of Addition of Fentanyl and Clonidine to Local Anesthetic Solution in Peribulbar Block

Nehra, Poonam; Oza, Vrinda; Parmar, Vandana; Fumakiya, Pooja

doi:10.4103/jpp.jpp_109_16

Cited by 13 publications

(6 citation statements)

References 43 publications

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“…Our results reported the evidence that addition of fentanyl to anesthesia mixture provide more rapid onset and duration of anesthesia & rapid onset of eyelid akinesia and duration for both lid and global akinesia & less pain perception and less need for analgesia. Poonam Nehra et al [17] compared the addition of fentanyl versus clonidine (selective alpha 2 agonist) to local anesthetic mixture in peribulbar block and reported that the onset time of globe akinesia was significantly shorter in fentanyl group (F) and clonidine group (C) compared to control group (S). They also documented that the durations of motor block and analgesia were significantly longer in Group F and group C compared to group S. The results of the present study are in accordance Open Journal of Anesthesiology with study done by Toshiharu et al [18] who studied the effect of supplementation of fentanyl to mepivacaine in epidural block and found that addition of fentanyl to mepivacaine accelerate the onset of analgesia and enhances the analgesic effect of epidural block.…”

Section: Discussionmentioning

confidence: 99%

Outcome Values of Adding Sodium Bicarbonate, Dexamethasone and Fentanyl to Local Anesthetic in Peribulbar Block during Vitreoretinal Surgeries. A Randomized Prospective Study

Arafa¹,

Elsayed²

2018

OJAnes

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Background and aims: we aimed to detect the outcome values of adding fentanyl, dexamethasone and sodium bicarbonate to mixture of local anesthetic in peribulbar block for vitreoretinal surgery. Methods: 120 adult ASA I & II patients, admitted for vitreoretinal surgery under peribulbar block were included in this comparative study. This study included 4 groups: Group I: (30) patients using a mixture of 1 ml normal saline, 4 ml lidocaine 2% plus 4 ml from bupivacaine 0.5% 20 ml vial containing hyaluronidase 1500 IU. Group II: (30) patients using a mixture of 1 ml of sodium bicarbonate (from 1 ml sodium bicarbonate 8.4% diluted in 10 ml normal saline), 4 ml lidocaine 2% plus 4 ml from bupivacaine 0.5% 20 ml vial containing hyaluronidase 1500 IU. Group III: (30) patients using a mixture of 1 ml fentanyl 20 μg (from a mixture of fentanyl 100 µg diluted in 5 ml normal saline), 4 ml lidocaine 2% plus 4 ml from bupivacaine 0.5% 20 ml vial containing hyaluronidase 1500 IU. Group IV: (30) patients using a mixture of 1 ml of 4 mg dexamethasone (1 ampoule = 8 mg/2 ml), 4 ml lidocaine 2% plus 4 ml from bupivacaine 0.5% 20 ml vial containing hyaluronidase 1500 IU. We measured the onset and duration of anesthesia, IOP, eyelid and global akinesia, postoperative pain by numerical pain rating scale, first analgesic requirement and postoperative side effects. Results: No significant differences were detected among the four groups as respect to age, sex and the intraocular pressure (IOP) before the anesthesia block. While the intraocular pressure (IOP) after the anesthesia block there was a significant difference, as IOP was markedly decreased postoperatively in group II compared with other groups. As regard to the onset

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Section: Discussionmentioning

confidence: 99%

Outcome Values of Adding Sodium Bicarbonate, Dexamethasone and Fentanyl to Local Anesthetic in Peribulbar Block during Vitreoretinal Surgeries. A Randomized Prospective Study

Arafa¹,

Elsayed²

2018

OJAnes

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“…Poonam Nehra et al [19] compared the addition of fentanyl vs. clonidine (alpha 2 agonist) to local anaesthetic mixture during peribulbar block and reported that the onset time of globe akinesia was significantly shorter in fentanyl group (F) and clonidine group (C) compared to control group (S). They also reported that the durations of motor block and analgesia were significantly longer in Group F and group C compared to group S. On the other hand Hala et al [4] , reported that adding clonidine to local anesthetics for peribulbar block was associated with insignificant difference regarding onset time for sensory and motor block (which disagreed with our result) and improvement in the duration and the quality of the block (which agree with our results).…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine vs. Fentanyl as Adjuvant to Local Anaesthetic Mixture in Peribulbar Block for Retinal Surgery: A Randomized Prospective Study

Khalil¹,

Marouf²

2017

J Anesth Clin Res

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“…Fentanyl has been added to local anesthetics used for regional anesthesia to improve analgesia (19)(20)(21)(22)(23)(24) . This practice has been taken to reduce complications of systemic opioids, for example cardiorespiratory depression, drowsiness, and postoperative nausea and vomiting (11,(25)(26)(27) .…”

Section: Introductionmentioning

confidence: 99%

The Effect of Adding Fentanyl to Peribulbar Block on Muscle Traction during Squint and Buckle Surgeries in Adult Patients: A Randomized Controlled Trial

Salem

Mohamed²,

Khattab³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: In squint and buckle surgeries, the intraoperative pain of muscle traction might not be completely prevented by local anesthetic (LA) drugs. Adding fentanyl to LA can avoid systemic opioids side effects. Objectives: The aim of the current work was to evaluate the safety and efficacy of adding fentanyl to peribulbar block to abolish or decrease muscle traction pain during squint or buckle operations. Patients and methods: This randomized clinical trial study included a total of 60 adult patients (18-65-year-old) of both genders booked for either squint or scleral buckle surgeries, attending at Research Institute of Ophthalmology, Giza, Egypt. Patients were allocated randomly into two groups (30 patients each); fentanyl group and control group. Intraoperative pain was the primary outcome, whereas secondary outcomes included the onset of complete akinesia and patient satisfaction. Results:The median pain score was 1 for both groups. Two patients of the fentanyl group and 5 patients of the control group required general anesthesia. The mean time to achieving complete akinesia was shorter in the fentanyl group with a significant statistical difference (134.2±35.8 vs. 156.3±34.7, p = 0.018). The patient satisfaction was more with fentanyl use but with no statistical significance. Conclusions: It could be concluded that fentanyl added to the local anesthesia mixture of peribulbar block in squint and scleral buckle surgeries shorten the time needed to achieve complete akinesia. However, it does not improve the intraoperative pain resulting from muscle traction. Also, it does not affect the need for general anesthesia or postoperative patient satisfaction.

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Effect of Addition of Fentanyl and Clonidine to Local Anesthetic Solution in Peribulbar Block

Cited by 13 publications

References 43 publications

Outcome Values of Adding Sodium Bicarbonate, Dexamethasone and Fentanyl to Local Anesthetic in Peribulbar Block during Vitreoretinal Surgeries. A Randomized Prospective Study

Outcome Values of Adding Sodium Bicarbonate, Dexamethasone and Fentanyl to Local Anesthetic in Peribulbar Block during Vitreoretinal Surgeries. A Randomized Prospective Study

Dexmedetomidine vs. Fentanyl as Adjuvant to Local Anaesthetic Mixture in Peribulbar Block for Retinal Surgery: A Randomized Prospective Study

The Effect of Adding Fentanyl to Peribulbar Block on Muscle Traction during Squint and Buckle Surgeries in Adult Patients: A Randomized Controlled Trial

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