Effect of Additional Statin Therapy on Endothelial Function and Prognosis in Patients With Vasospastic Angina

Yun, Kyeong Ho; Shin, Ik Sang; Park, Eun Mi; Rhee, Sang Hoon; Lee, Eun Mi; Yoo, Nam Jin; Kim, Nam Ho; Oh, Seok Kyu; Jeong, Jin Won

doi:10.4070/kcj.2008.38.12.638

Cited by 10 publications

(7 citation statements)

References 25 publications

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“…Thirdly, because the present study has no control group, the effect of diltiazem or nitrate on the improvement of FMD could not be completely excluded. Considering the previous study of Yun et al16) which showed the use of statin significantly improves FMD regardless of the use of calcium channel blocker or nitrate, the use of statin would be a major factor for the improvement of FMD in the present study.…”

Section: Discussionmentioning

confidence: 60%

“…The study of Yun et al,16) furthermore, demonstrated that 10 mg of rosuvastatin could improve endothelial function as assessed by FMD and endothelial progenitor cell counts in patients with VAP. The result of the present study was similar to the study of Yun et al16) except for the type of the used statin. Both atorvastatin 10 mg and 40 mg could improve FMD after 6 months of therapy in the present study.…”

Section: Discussionmentioning

confidence: 95%

“…It has also been proved that the use of statin is associated with the improvement of endothelial function in various cardiovascular diseases and diabetes 14)21-24). The study of Yun et al,16) furthermore, demonstrated that 10 mg of rosuvastatin could improve endothelial function as assessed by FMD and endothelial progenitor cell counts in patients with VAP. The result of the present study was similar to the study of Yun et al16) except for the type of the used statin.…”

Section: Discussionmentioning

confidence: 97%

“…The use of statin can retard the progression or induce the regression of carotid atherosclerosis. Furthermore, the study of Yun et al16) demonstrated that statin therapy could improve endothelial dysfunction in Korean patients with VAP. However, the impacts of statin dose on endothelial function and carotid IMT in Korean patients with VAP has been poorly evaluated.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Low Dose versus High Dose Statin Therapy on the Changes of Endothelial Function and Carotid Intima-Media Thickness in Patients with Variant Angina

Kim

Cho

Yim

et al. 2013

J Cardiovasc Ultrasound

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BackgroundTo compare the effects of low dose and high dose of statin treatment on endothelial function and carotid intima-media thickness (IMT) in patients with variant angina (VAP).MethodsA total of 70 patients with VAP were divided into two groups; atorvastatin 10 mg treatment group (group I: n = 35, 54.2 ± 12.5 years) versus atorvastatin 40 mg treatment group (group II: n = 35, 52.6 ± 9.8 years). Flow mediated vasodilation (FMD) of the brachial artery and IMT of the carotid artery were compared between the groups after 6 months of statin treatment.ResultsThe baseline FMD and carotid IMT were not different between the groups. After 6 months of statin therapy, FMD was significantly improved in both groups (7.7 ± 2.5% to 8.9 ± 2.2% in group I, p = 0.001, 7.9 ± 2.7% to 9.5 ± 2.8% in group II, p < 0.001), but the degree of FMD change and FMD at 6 month were not different between the groups. Carotid IMT were not changed in both groups after 6 months of statin therapy.ConclusionThe use of statin for 6 months significantly improved endothelial function in patients with VAP, but carotid IMT was not changed. The use of high dose statin did not show significant additional benefit as compared with the use of low dose statin. The present study suggested that statin therapy would be beneficial in the treatment of VAP.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Low Dose versus High Dose Statin Therapy on the Changes of Endothelial Function and Carotid Intima-Media Thickness in Patients with Variant Angina

Kim

Cho

Yim

et al. 2013

J Cardiovasc Ultrasound

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show abstract

“…Pleiotropic effects encompass non-lipid mechanisms that modify endothelial function, inflammatory responses, plaque stability and thrombus formation [11][12][13]. These effects may potentially improve clinical outcomes after PCI.…”

Section: Discussionmentioning

confidence: 98%

12-month follow-up results of high dose rosuvastatin loading before percutaneous coronary intervention in patients with acute coronary syndrome

Yun

Rhee

et al. 2011

International Journal of Cardiology

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Clinical impact of statin therapy on vasospastic angina: data from a Korea nation-wide cohort study

Seo

Kim

et al. 2020

Heart Vessels

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Effect of Additional Statin Therapy on Endothelial Function and Prognosis in Patients With Vasospastic Angina

Cited by 10 publications

References 25 publications

Effects of Low Dose versus High Dose Statin Therapy on the Changes of Endothelial Function and Carotid Intima-Media Thickness in Patients with Variant Angina

Effects of Low Dose versus High Dose Statin Therapy on the Changes of Endothelial Function and Carotid Intima-Media Thickness in Patients with Variant Angina

12-month follow-up results of high dose rosuvastatin loading before percutaneous coronary intervention in patients with acute coronary syndrome

Clinical impact of statin therapy on vasospastic angina: data from a Korea nation-wide cohort study

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