Effect of additional vitaminEand zinc supplementation on immunological changes in peripartumSahiwal cows

Abstract

This study was conducted to exploit ameliorative effect of additional vitamin E and/or zinc supplementation on immune response of peripartum Sahiwal cows. Thirty-two pregnant dry Sahiwal cows were blocked into four treatment groups (n = 8), namely control, zinc (Zn), vitamin E (Vit E) and zinc + vitamin E (Zn + Vit E). Feeding regimen was same in all the groups except that the Sahiwal cows in the zinc-, vitamin E- and zinc + vitamin E-fed groups were additionally supplemented with 60 mg Zn/kg DM, 1000 IU vitamin E and 60 mg/kg + 1000 IU Zn + vitamin E, respectively, from day 60 pre-partum to day 90 post-partum. Blood samples were collected on days -60, -45, -30, -15, -7, -3, 0, 3, 7, 15, 30, 45, 60, 90 and 120 with respect to day of parturition and analysed for total immunoglobulin (TIG), immunoglobulin G (IgG), interleukin-2 (IL-2), vitamin E (Vit E) and zinc (Zn) status. Before calving, cows showed a decrease in plasma TIG, IgG, IL-2, Vit E and Zn levels. However, increased levels of plasma TIG, IgG, IL-2, Vit E and Zn were observed after calving. After calving, Sahiwal cows supplemented with Zn + Vit E had higher plasma TIG, IgG and IL-2 in comparison with cows of control and Zn + Vit E-fed groups. In the present study, plasma vitamin E level was higher in Vit E-fed and Zn + Vit E-fed cows; however, zinc level was higher in Zn- and Zn + Vit E-supplemented cows. In conclusion, a reduced immune response during peripartum period in Sahiwal cows was ameliorated by dietary vitamin E and zinc supplementation.

The effect of additional supplementation of vitamin E and zinc on endocrine and metabolic changes in dairy cows during peripartal period

“…Stress promotes the formation of metallothionein that is impart in Zn metabolism which results in the redistribution of Zn from the blood to other tissues (XIN et al, 1993). Supplementation of Zn during the dry period and early lactation enhanced plasma concentrations of Zn, which was also found by CHANDRA et al (2014) in Sahiwal cows.…”

A meta-analysis and meta-regression of the effects of vitamin E supplementation on serum enrichment, udder health, milk yield, and reproductive performance of transition cows

“…Thus, the controversial outcomes of previous studies might be due to different sources of variation and interactions, which cannot be fully controlled in single trials. Several other factors may affect vitamin E availability and its efficiency in animals, including source of the vitamin E active substance, other nutrients in feeds (Campbell and Miller, 1998;Chandra et al, 2014), timing, inclusion of Se (Aréchiga et al, 1994), variation in vitamin E content of the basal ration (Lindqvist et al, 2011), and method of administration (e.g., ruminal pellets or premixes in diet, or even i.v., s.c., and i.m. injection; Aréchiga et al, 1994;Bayril et al, 2015), applied over different time spans and frequencies with cows fed different diets and levels of production.…”

Effects of dietary adsorbent on milk aflatoxin M1 content and the health of lactating dairy cows exposed to long-term aflatoxin B1 challenge

“…Beyond the lack of effects of 7 d of addition of Solis Mos in AFB1-free or contaminated diets on plasma concentration of IgG, IgM, and IgA in dairy cows in our previous study (Xiong, et al, 2015), the long-term addition of Solis Mos improved the immune condition of dairy cows, thus suggesting that extended supplementation may confer beneficial immunological effects. Adding vitamin E as an ingredient in Solis Mos into cow diets from d 60 prepartum to d 90 postpartum has been observed to increase plasma concentration of total immunoglobulin, IgG, and IL-2 (Chandra et al, 2014). Moreover, He et al (2013) reported that vitamin E and selenium yeast partially ameliorated the adverse effects of AFB1-contaminated diets on growth performance, immunity, and relative immune organ weight in ducks.…”