Effect of additives on mixed micellization of a phenothiazine drug promethazine hydrochloride and an ester-based pyridinium gemini surfactant

The focus of the present work is to evaluate the interactions of an anti-allergic drug (diphenhydramine hydrochloride, DPH) with anionic (sodium dodecyl sulfate, SDS) and cationic (cetylpyridinium chloride, CPC) surfactants in the aqueous medium. The mixed micellization behavior and surface properties of drug-surfactant mixtures have been examined by surface tension measurements. Various theoretical approaches were applied to explore the synergistic or non-ideal behavior of the current mixed systems. Furthermore, the binding studies of drug with surfactants have been elaborated by UV–visible spectroscopy. Benesi–Hildebrand (B-H) theory was used to compute stoichiometric ratio, binding constant, and free energy change for the drug-surfactant mixtures. The outputs are deliberated taking into consideration the use of surfactants as capable drug delivery agents for DPH and hence advance bioavailability.

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“…For a multi-component system having n species and total concentration C , the equation may be written as [ 45 , 46 , 47 ]

where n represents the number of species present in the solution, and its value can be calculated by the relation [ 20 ]

…”

Section: Resultsmentioning

confidence: 99%

“…where γ = surface tension Γ i = surface excess µ i = chemical potential of the ith components in the solution For a multi-component system having n species and total concentration C, the equation may be written as [45][46][47]…”

Section: Surface Parameters Of Drug-surfactants Mixturesmentioning

confidence: 99%

Interaction of Diphenhydramine Hydrochloride with Cationic and Anionic Surfactants: Mixed Micellization and Binding Studies

et al. 2021

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“…C, R, and T have their usual standard meanings; n is the number of species present in the solution and its value varies with the nature of amphiphilic molecule. The gemini surfactants with small spacers and having a monovalent counterion associated with each head group (Shaheen and Mir, 2019;Patial et al, 2014a), the value of n is taken to be 2, which is applicable in our case too. The differential part of the equation was solved from the γ plots at constant temperature.…”

Section: Surface and Interfacial Studiesmentioning

confidence: 99%

“…Gemini surfactants have attracted the attention of global scientific community because of their superior physicochemical properties and potential applications in diverse fields as compared to the conventional monomeric surfactant molecules (Dani et al, 2018;Xu et al, 2017). Structurally, being the dimers of covalently bonded simple single-chain surfactants, gemini surfactants bear two head groups and two long hydrocarbon tails held together by a spacer (Liu et al, 2020;Patial et al, 2014a;Shaheen and Mir, 2019). The gemini surfactants have lower critical micelle concentration (cmc) values, unusual aggregation behavior, better wetting, foaming, and solubilizing properties besides having greater adsorption efficiency and viscosity behavior than conventional surfactant molecules (Chauhan et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Surface, Micellar, and Aggregation Behavior of Non‐cytotoxic Imidazolium Gemini Surfactants

Shaheen

Mir

Arif

et al. 2020

J Surfact & Detergents

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The micellar, surface, and aggregation properties of biocompatible, imidazolium-based hydroxyl group-Br 2 , were studied. The surface parameters like maximum surface excess concentration at air/water interface (Γ max ), the minimum surface area occupied by surfactant molecules (A min ) and the related thermodynamic parameters such as, standard Gibbs free energy of micellization (ΔG 0 m ), standard free energy of adsorption (ΔG 0 ad ), and free energy of surface at equilibrium ðG s min ) were also determined from the surface parameters. The aggregation behavior has been elucidated from transmission electron microscopy (TEM) and dynamic light scattering (DLS) techniques which showed that these gemini surfactants have potential self-aggregation efficiency. Besides, some other physicochemical properties like foam stability, emulsifying power, and viscosity have been determined. The structural features of [C n Im-3OH-ImC n ]Br 2 enhance their surface-active properties. These features of gemini surfactants are of primary significance from pharmaceutical and biomedical viewpoints. The gemini surfactants may have great implications in drug formulations and delivery owing to their prominent aggregation and non-cytotoxic nature.

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Synthesis, micellization and cytotoxic studies of ester‐functionalized imidazolium gemini surfactants

Mir

Shaheen

Wani

et al. 2021

J Surfact & Detergents

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The fatty acid-based imidazolium gemini surfactants containing hydroxysubstituted spacers were synthesized and characterized by different spectral techniques. The micellization behavior of product compounds was studied by determining their critical micelle concentration (cmc) values from steady state fluorescence and conductivity measurements. The thermodynamic parameters of micellization of synthesized gemini surfactants confirmed that the micelle formation is a thermodynamically favorable, endothermic and an entropy driven phenomenon. The surfactants were further analyzed for their cytotoxic nature by treating them upon human embryonic kidney cell (HEK-293) line and were found to be significantly low cytotoxic. The interesting features like low cmc values, non-cytotoxic and eco-friendly nature of the gemini surfactants may offer new and more efficient substitutes to the conventional drug delivery systems. Thus the gemini surfactants may serve as promising candidates in the biomedical and pharmaceutical fields.

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Effect of additives on mixed micellization of a phenothiazine drug promethazine hydrochloride and an ester-based pyridinium gemini surfactant

Cited by 11 publications

References 60 publications

Interaction of Diphenhydramine Hydrochloride with Cationic and Anionic Surfactants: Mixed Micellization and Binding Studies

Interaction of Diphenhydramine Hydrochloride with Cationic and Anionic Surfactants: Mixed Micellization and Binding Studies

Surface, Micellar, and Aggregation Behavior of Non‐cytotoxic Imidazolium Gemini Surfactants

Synthesis, micellization and cytotoxic studies of ester‐functionalized imidazolium gemini surfactants

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