2011
DOI: 10.1007/s12640-011-9263-x
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Effect of Adenosine A2A Receptor Antagonists and l-DOPA on Hydroxyl Radical, Glutamate and Dopamine in the Striatum of 6-OHDA-Treated Rats

Abstract: A2A adenosine receptor antagonists have been proposed as a new therapy of PD. Since oxidative stress plays an important role in the pathogenesis of PD, we studied the effect of the selective A2A adenosine receptor antagonists 8-(-3-chlorostyryl)caffeine (CSC) and 4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol (ZM 241385) on hydroxyl radical generation, and glutamate (GLU) and dopamine (DA) extracellular level using a microdialysis in the striatum of 6-OHDA-treated rats. CS… Show more

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Cited by 20 publications
(14 citation statements)
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“…The protective effect of caffeine and more selective antagonists of A 2A receptors, similar to genetic inactivation of A 2A receptors, was observed in an animal MPTP neurotoxicity model (Chen et al 2007) or in ischemia and excitotoxic brain injury models (Popoli et al 2004; Chen et al 2007). The mechanism of neuroprotective action of A 2A receptor antagonists is not fully understood but attenuation of overactive glutamate overflow and abatement of oxidative stress may be of importance as shown by several our studies (Gołembiowska et al 2009; Gołembiowska and Dziubina 2012a, b). …”
Section: Introductionmentioning
confidence: 90%
“…The protective effect of caffeine and more selective antagonists of A 2A receptors, similar to genetic inactivation of A 2A receptors, was observed in an animal MPTP neurotoxicity model (Chen et al 2007) or in ischemia and excitotoxic brain injury models (Popoli et al 2004; Chen et al 2007). The mechanism of neuroprotective action of A 2A receptor antagonists is not fully understood but attenuation of overactive glutamate overflow and abatement of oxidative stress may be of importance as shown by several our studies (Gołembiowska et al 2009; Gołembiowska and Dziubina 2012a, b). …”
Section: Introductionmentioning
confidence: 90%
“…Interestingly, ZM 241385 and CSC also potentiated L-DOPA-induced DA in the striatum of intact, but not DA-denervated rats. The potentiating effect of ZM 241385 and CSC on striatal DA release was also observed in reserpine-pretreated rats (Golembiowska and Dziubina 2004, 2012a, 2012b. It is possible that the mechanisms of A 2A -mediated potentiation haloperidol-and L-DOPAinduced DA release are complimentary.…”
mentioning
confidence: 78%
“…Chronic systemic administration of ZM 241385 or of another antagonist of A 2A receptors, CSC, did not alter striatal DA levels as well (Golembiowska and Dziubina 2012a). The novel antagonist of A 2A and A 1 receptors, JNJ-40255293, did not alter cortical and striatal DA levels as well (Atack et al 2014).…”
mentioning
confidence: 89%
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“…In addition, in order to verify the selectivity of action on A 2A receptors, the effects of PSB-0777 on the inflammatory parameters were evaluated either in the absence or in the presence of CSC, a selective A 2A adenosine receptor antagonist (1 mg/kg/day). An effective and selective dose of the receptor antagonist was chosen on the basis of previous reports [19,20].…”
Section: Induction Of Colitis Drug Treatments and Experimental Designmentioning
confidence: 99%