Effect of adenosine triphosphate-sensitive potassium activation on peripheral and central pain sensitization

Shen, Shiren; Cao, Sheng‐Li; Huang, Saisai; Chen, Junjie

doi:10.1016/j.jss.2015.01.033

Cited by 2 publications

(3 citation statements)

References 14 publications

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“…Unfortunately, most studies have not closely investigated which K ATP channel subunits are contributing to the analgesic effects of these treatments or where these K ATP channels are located (e.g., spinal cord versus peripheral nervous system). Previous data suggest that Kir6.2/SUR1 is the predominant functional subtype within the peripheral nervous system but pain sensitization appears to be mediated mostly by SUR2 after cutaneous injury [9,10,11,12,13,14]. Current data are also lacking on K ATP channel expression changes occurring after initiation of chronic pain in the peripheral versus central nervous system over an extended (>30 days) period of time.…”

Section: Introductionmentioning

confidence: 99%

Modulation of SUR1 KATP Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice

Luu

Bjork

Salo

et al. 2019

IJMS

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The ATP-sensitive K+ channel (KATP) is involved in hypersensitivity during chronic pain and is presumed to be a downstream target of mu opioid receptors. Multiple subtypes of KATP channels exist in the peripheral and central nervous system and their activity may be inversely correlated to chronic pain phenotypes in rodents. In this study, we investigated the different KATP channel subunits that could be involved in neuropathic pain in mice. In chronic pain models utilizing spinal nerve ligation, SUR1 and Kir6.2 subunits were found to be significantly downregulated in dorsal root ganglia and the spinal cord. Local or intrathecal administration of SUR1-KATP channel subtype agonists resulted in analgesia after spinal nerve ligation but not SUR2 agonists. In ex-vivo nerve recordings, administration of the SUR1 agonist diazoxide to peripheral nerve terminals decreased mechanically evoked potentials. Genetic knockdown of SUR1 through an associated adenoviral strategy resulted in mechanical hyperalgesia but not thermal hyperalgesia compared to control mice. Behavioral data from neuropathic mice indicate that local reductions in SUR1-subtype KATP channel activity can exacerbate neuropathic pain symptoms. Since neuropathic pain is of major clinical relevance, potassium channels present a target for analgesic therapies, especially since they are expressed in nociceptors and could play an essential role in regulating the excitability of neurons involved in pain-transmission.

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Section: Introductionmentioning

confidence: 99%

Modulation of SUR1 KATP Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice

Luu

Bjork

Salo

et al. 2019

IJMS

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“…agonists can significantly reduce postoperative pain in rats by inhibiting the apoptosis of vascular endothelial cells around the incision (10,11). The KaTP activator nicorandil is a nitric oxide donor approved for the treatment of patients with angina pectoris, which also exhibits activities in models of inflammatory and nociceptive pain (12,13).…”

Section: Discussionmentioning

confidence: 99%

“…our previous studies have shown that adenosine triphosphate-sensitive potassium channel (KaTP) agonists may relieve postoperative pain in rats by inhibiting the apoptosis of vascular endothelial cells (10,11). KaTP agonists can inhibit touch-induced pain in a dose-dependent manner (11).…”

Section: Introductionmentioning

confidence: 99%

Effects of nicorandil on p120 expression in the spinal cord and dorsal root ganglion of rats with chronic postsurgical pain

Huang

Cao

et al. 2020

Mol Med Rep

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chronic postsurgical pain (cPSP) has a high incidence, but the underlying mechanism is not well understood. accumulating evidence has suggested that central sensitization is the main mechanism of pain. To study the role of p120 in cPSP, a skin/muscle incision and retraction (SMir) model was established, and immunofluorescence staining and western blotting were performed to analyze the expression of p120 in the spinal cord and dorsal root ganglion (drG). The results demonstrated that SMir increased the expression of p120 in the drG and the spinal cord compared with the naive group. Furthermore, it was demonstrated that p120 was mainly distributed in the glial fibrillary acidic protein-positive astrocytes in the spinal cord, and in the neurofilament 200-positive medium and large neurons in the drG. our previous studies have shown that adenosine triphosphate-sensitive potassium channel (KaTP) agonists can reduce postoperative pain in rats. Therefore, the changes in p120 were observed in the drG and spinal cord of rats following the intraperitoneal injection of nicorandil, a KaTP agonist. it was demonstrated that nicorandil administration could relieve mechanical pain experienced following SMir in rats, and decrease the expression of p120 in the drG and spinal cord. The results revealed that p120 may contribute to the prophylactic analgesic effect of nicorandil, thus providing a novel insight into the mechanism of cPSP prevention.

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Effect of adenosine triphosphate-sensitive potassium activation on peripheral and central pain sensitization

Cited by 2 publications

References 14 publications

Modulation of SUR1 KATP Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice

Modulation of SUR1 KATP Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice

Effects of nicorandil on p120 expression in the spinal cord and dorsal root ganglion of rats with chronic postsurgical pain

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