Effect of ADHD medication in male C57BL/6J mice performing the rodent Continuous Performance Test

Caballero-Puntiverio, Maitane; Lerdrup, Linda; Grupe, Morten; Larsen, C. W.; Dietz, Andrea Grostøl; Andreasen, J. T.

doi:10.1007/s00213-019-5167-x

“…In order to investigate the neural mechanisms of attention orienting, two attentionmodulating treatments, methylphenidate (MPH) and atomoxetine (ATX), were administered to the mice in the current tasks. MPH and ATX were observed to improve sustained and selective attention in mice in some studies [31,41], but neither treatment exhibited significant effects on attention orienting (i.e., the orienting effects) in the current tasks. One possible explanation is that the noradrenergic (NA) and dopaminergic (DA) signalling systems, that are modulated by these compounds, have limited or indirect effects on attention orienting.…”

Section: Effects Of Drugs: Mph and Atx Exerted Mixed Effects On Exogementioning

confidence: 77%

“…Methylphenidate (MPH, Cat # M325880, Toronto Research Chemicals) and Atomoxetine (ATX, Cat # Y0001586; Sigma-Aldrich) were dissolved in 0.9% (w/v) sodium chloride, administered intraperitoneally, 30 minutes prior to testing in an injection volume of 10 ml/kg and dose of 3 mg/kg. The doses of MPH and ATX were selected based on previous touchscreen studies that assessed attention in C57BL/6J mice [31].…”

Section: Drugs and Treatmentsmentioning

confidence: 99%

Assessing attention orienting in mice: a novel touchscreen adaptation of the Posner-style cueing task

Li

¹

,

May

²

,

Hannan

³

et al. 2020

Neuropsychopharmacol.

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Atypical attention orienting has been found to be impaired in many neuropsychological disorders, but the underlying neural mechanism remains unclear. Attention can be oriented exogenously (i.e., driven by salient stimuli) or endogenously (i.e., driven by one's goals or intentions). Genetic mouse models are useful tools to investigate the neurobiology of cognition, but a well-established assessment of attention orienting in mice is missing. This study aimed to adapt the Posner task, a widely used attention orienting task in humans, for use in mice using touchscreen technology and to test the effects of two attention-modulating drugs, methylphenidate (MPH) and atomoxetine (ATX), on the performance of mice during this task. In accordance with human performance, mice responded more quickly and more accurately to validly cued targets compared to invalidly cued targets, thus supporting mice as a valid animal model to study the neural mechanisms of attention orienting. This is the first evidence that mice can be trained to voluntarily maintain their nose-poke on a touchscreen and to complete attention orienting tasks using exogenous peripheral cues and endogenous symbolic cues. The results also showed no significant effects of MPH and ATX on attention orienting, although MPH improved overall response times in mice during the exogenous orienting task. In summary, the current study provides a critical translational task for assessing attention orienting in mice and to investigate the effects of attention-modulating drugs on attention orienting.

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“…Similarly, previous studies have suggested that ATX reduces impulsive actions in rodents [39,48,49] and humans [50,51], in contrast to MPH [31,52,53]. The differential effects of MPH and ATX on impulsive actions has been suggested to reflect their differential roles on subcortical dopamine neurotransmission [24,41].…”

Section: Effects Of Drugs: Mph and Atx Exerted Mixed Effects On Exogementioning

confidence: 80%

“…In order to investigate the neural mechanisms of attention orienting, two attentionmodulating treatments, methylphenidate (MPH) and atomoxetine (ATX), were administered to the mice in the current tasks. MPH and ATX were observed to improve sustained and selective attention in mice in some studies [31,41], but neither treatment exhibited significant effects on attention orienting (i.e., the orienting effects) in the current tasks. One possible explanation is that the noradrenergic (NA) and dopaminergic (DA) signalling systems, that are modulated by these compounds, have limited or indirect effects on attention orienting.…”

Section: Effects Of Drugs: Mph and Atx Exerted Mixed Effects On Exogementioning

confidence: 96%

“…Atomoxetine (ATX, Cat # Y0001586; Sigma-Aldrich) were dissolved in 0.9% (w/v) sodium chloride, administered intraperitoneally, 30 minutes prior to testing in an injection volume of 10 ml/kg and dose of 3 mg/kg. The doses of MPH and ATX were selected based on previous touchscreen studies that assessed attention in C57BL/6J mice [31].…”

Section: Drugs and Treatmentsmentioning

confidence: 99%

See 1 more Smart Citation

Assessing Attention Orienting in Mice: A Novel Touchscreen Adaptation of the Posner-Style Cueing Task

Li

¹

,

May

²

,

Hannan

³

et al. 2020

Preprint

View full text Add to dashboard Cite

Atypical attention orienting has been found to be impaired in many neuropsychological disorders, but the underlying neural mechanism remains unclear. Attention can be oriented exogenously (i.e., driven by salient stimuli) or endogenously (i.e., driven by one's goals or intentions). Genetic mouse models are useful tools to investigate the neurobiology of cognition, but a well-established assessment of attention orienting in mice is missing. This study aimed to adapt the Posner task, a widely used attention orienting task in humans, for use in mice using touchscreen technology and to test the effects of two attention-modulating drugs, methylphenidate (MPH) and atomoxetine (ATX), on the performance of mice during this task. In accordance with human performance, mice responded more quickly and more accurately to validly cued targets compared to invalidly cued targets, thus supporting mice as a valid animal model to study the neural mechanisms of attention orienting. This is the first evidence that mice can be trained to voluntarily maintain their nose-poke on a touchscreen and to complete attention orienting tasks using exogenous peripheral cues and endogenous symbolic cues. The results also showed no significant effects of MPH and ATX on attention orienting, although MPH improved overall response times in mice during the exogenous orienting task. In summary, the current study provides a critical translational task for assessing attention orienting in mice and to investigate the effects of attention-modulating drugs on attention orienting.

show abstract

Preclinical Evaluation of Attention and Impulsivity Relevant to Determining ADHD Mechanisms and Treatments

Kenton

¹

,

Young

²

2022

New Discoveries in the Behavioral Neuroscience of Attention-Deficit Hyperactivity Disorder

5

0

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Effect of ADHD medication in male C57BL/6J mice performing the rodent Continuous Performance Test

Cited by 36 publications

References 56 publications

Assessing attention orienting in mice: a novel touchscreen adaptation of the Posner-style cueing task

Assessing attention orienting in mice: a novel touchscreen adaptation of the Posner-style cueing task

Assessing Attention Orienting in Mice: A Novel Touchscreen Adaptation of the Posner-Style Cueing Task

Preclinical Evaluation of Attention and Impulsivity Relevant to Determining ADHD Mechanisms and Treatments

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