Effect of adjunctive use of systemic antioxidant therapy (<i>N</i>-acetylcysteine) on soluble receptor activator nuclear factor κB ligand levels in gingival crevicular fluid following surgical periodontal treatment for chronic periodontitis

Abstract

N-acetylcysteine (NAC) is an anti-oxidantdrug that has been used as a mucolytic agent and a paracetamol antidote for many years. This study was designed to determine the efficacy of the adjunctive use of NAC for periodontal treatment. Thirty subjects with moderate-to-severe chronic periodontitis were randomized to surgery with NAC (600 mg; S-NAC), surgery only (S-nonNAC), and healthy control groups. Gingival crevicular fluid (GCF) samples were obtained from all patients and sRANKL levels were determined by enzyme-linked immunosorbent assay at baseline, and 1, 3, and 7 months post-surgery. Plaque and gingival indices, probing depths, and clinical attachment levels were recorded at the same time. There was a significant reduction in probing depth at 3 months in the S-NAC group when compared to the S-nonNAC group (P < 0.05). However, no statistically significant differences in plaque and gingival indices, probing depths, clinical attachment levels, and sRANKL levels in GCF were noted between the surgical treatment groups at the end of 7 months. Hence, the use of adjunctive NAC resulted in a significant reduction in probing depths in the S-NAC group when compared to the S-nonNAC group at 3 months, but no statistically significant differences in GCF sRANKL levels were observed in the sites that underwent surgical treatment with or without NAC at different time intervals.

Antioxidants as Adjuvants in Periodontitis Treatment: A Systematic Review and Meta-Analysis

“…All 1884 remaining articles were analyzed by titles and abstracts, based on the eligibility criteria, and then 1831 were excluded. Thirty-six studies were analyzed in full text, and 21 of them were excluded, having 15 articles remaining that were included in this review to qualitative synthesis [19–33], and 7 of them were designated to quantitative synthesis [19, 22, 23, 25, 28, 30, 32] (Figure 1).…”

Assessment of Renal and Hepatic Tissue-Protective Effects of N-Acetylcysteine via Ammonia Metabolism: A Prospective Randomized Study

“…There have been several studies demonstrating the beneficial effects of N-acetylcysteine on renal and hepatic functions [ 12 – 16 ]. N-acetylcysteine has begun to be used in a wide variety of clinical settings, including management of chronic periodontitis, treatment of acute pulmonary damage, palliation of peripheral neurotoxicity, to provide myocardial protection during extracorporeal circulation, and to prevent atrial fibrillation after CABG [ 17 – 20 ]. NAC has been reported to be beneficial due to its anti-oxidant and central anti-inflammatory properties.…”

Клинико-Лабораторная Эффективность Включения Ремаксола В Комплексную Терапию Пациентов С Хроническим Пародонтитом

“…Íàèáîëåå òÿaeåëîé è ðàñïðîñòðàíåííîé ôîðìîé ïîðàaeåíèÿ ïàðîäîíòà ïðèíÿòî ñ÷èòàòü õðîíè÷åñêèé ãåíåðàëèçîâàííûé ïàðîäîíòèò, êîòîðûé õàðàêòåðèçóåòñÿ ðåöèäèâèðóþùèì òå÷åíèåì, ÷àñòî ïðèâîäèò ê âûðàaeåííîìó íàðóøåíèþ ôóíêöèé çóáî÷åëþñòíîãî àïïàðàòà èç-çà ðåçîðáöèè êîñòíîé òêàíè, ãèáåëè óäåðaeèâàþùèõ çóáû òêàíåé è óòðàòå çóáîâ [7,8].  íàñòîÿùåå âðåìÿ ñóùåñòâóåò áîëüøîå êîëè÷åñòâî ñõåì è ìåòîäîâ êîìïëåêñíîãî ëå÷åíèÿ õðîíè÷åñêîãî ïàðîäîíòèòà, íî äàííûé âîïðîñ àêòóàëåí â ñòîìàòîëîãèè â ñâÿçè ñ íåäîñòàòî÷íîé ýôôåêòèâíîñòüþ ïîñëåäíèõ [6,8,12,13,18]. Øèðîêîå ïðèìåíåíèå â ñòîìàòîëîãè÷åñêîé ïðàêòèêå íàøëè ëåêàðñòâåííûå ïðåïàðàòû àíòèîêñèäàíòíîãî òèïà äåéñòâèÿ [13,14,17].…”

“… íàñòîÿùåå âðåìÿ ñóùåñòâóåò áîëüøîå êîëè÷åñòâî ñõåì è ìåòîäîâ êîìïëåêñíîãî ëå÷åíèÿ õðîíè÷åñêîãî ïàðîäîíòèòà, íî äàííûé âîïðîñ àêòóàëåí â ñòîìàòîëîãèè â ñâÿçè ñ íåäîñòàòî÷íîé ýôôåêòèâíîñòüþ ïîñëåäíèõ [6,8,12,13,18]. Øèðîêîå ïðèìåíåíèå â ñòîìàòîëîãè÷åñêîé ïðàêòèêå íàøëè ëåêàðñòâåííûå ïðåïàðàòû àíòèîêñèäàíòíîãî òèïà äåéñòâèÿ [13,14,17]. Ó÷èòûâàÿ çíà÷èìîñòü íàðóøåíèé ìèêðîöèðêóëÿöèè, îêèñëèòåëüíîãî ñòðåññà â ïàòîãåíåçå õðîíè÷åñêîãî ïàðîäîíòèòà [2,4,7,10], ïåðñïåêòèâíûì ïðåäñòàâëÿåòñÿ ïðèìåíåíèå ìåòàáîëè÷åñêèõ ïðåïàðàòîâ ñ àí-òèîêñèäàíòíîé è àíòèãèïîêñàíòíîé àêòèâíîñòüþ, â ÷àñòíîñòè ðåìàêñîëà (ÎÎÎ "ÍÒÔÔ "Ïîëèñàí", Ñàíêò-Ïåòåðáóðã).…”

“…Âàaeíûì ïàòîãåíåòè÷åñêèì ìåõàíèçìîì àëüòåðàöèè òêàíåé ïàðîäîíòà ïðè ãåíåðàëèçîâàííîì ïàðîäîíòèòå ÿâëÿåòñÿ àêòèâèçàöèÿ ñâîáîäíîðàäèêàëüíîãî îêèñëåíèÿ êàê íà ìåñòíîì, òàê è íà ñèñòåìíîì óðîâíÿõ [4,13]. Èçó÷åíèå äàííûõ ïðîöåññîâ â ïëàçìå êðîâè ìåòîäîì õåìèëþìèíåñöåíöèè òàêaeå ïîêàçàëî èõ èíòåíñèôèêàöèþ ïðè õðîíè÷åñêîì ïàðîäîíòèòå.…”