Effect of administration of adrenocorticotropic hormone on plasma concentrations of testosterone, luteinizing hormone, follicle stimulating hormone and cortisol in stallions

Wiest, J.J.; Thompson, Donald L.; McNeill-Wiest, D.R.; Garza, F.; Mitchell, P. S.

doi:10.1016/s0737-0806(88)80043-1

Cited by 11 publications

(13 citation statements)

References 15 publications

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“…Thus, in our study, as a second treatment, we stimulated cortisol concentrations in stallions by administration of synthetic ACTH. Salivary cortisol concentrations reached a maximum at 2 hours after ACTH injections but decreased rapidly thereafter, which is in agreement with previous studies [18][19][20][21]. To achieve elevated cortisol concentrations for the same duration as in the transported stallions, three ACTH treatments at 4-hour intervals had to be given.…”

Section: Discussionsupporting

confidence: 90%

Increased cortisol release and transport stress do not influence semen quality and testosterone release in pony stallions

Deichsel

Pasing²,

Erber³

et al. 2015

Theriogenology

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Section: Discussionsupporting

confidence: 90%

Increased cortisol release and transport stress do not influence semen quality and testosterone release in pony stallions

Deichsel

Pasing²,

Erber³

et al. 2015

Theriogenology

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“…Blood collections apparently did not promote any stress condition, according to cortisol levels observed in this study (Thrall, Weiser, Allison, & Campbell, ). This observation becomes relevant since the interaction between cortisol and testosterone was previously confirmed in some species like swine (Liptrap & Raeside, ) and ovine (Mohamed, Cox, & Moonan, ); however, in stallions, the relation between cortisol and testosterone is still a matter of discussion, with inconsistent results (Aurich et al., ; Cox & Jawad, ; Deichsel et al., ; Liptrap & Raeside, ; Rabb et al., ; Seale, ; Villani et al., ; Wiest, Thompson, McNeill‐Wiest, Garza, & Mitchell, ).…”

Section: Discussionmentioning

confidence: 88%

Testosterone serum profile, semen characteristics and testicular biometry of Mangalarga Marchador stallions in a tropical environment

Waddington

Penitente-Filho

Neves

et al. 2017

Reprod Domestic Animals

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This study was conducted to characterize the daily profile of testosterone secretion and its mean concentrations in the four seasons as well as to evaluate the semen characteristics and testicular biometry of Mangalarga Marchador stallions throughout the year in a tropical region. Three stallions were submitted to semen collections and evaluation of testicular biometry every 14 days along a year. Blood samples were collected once at the middle of each season, in a 20-min interval during 24 hr in order to evaluate the testosterone secretion profiles among seasons. Testosterone concentrations along the day were higher at the beginning of the afternoon (from 12:00 to 15:00 hr), but a circadian secretion was not clearly observed. Mean testosterone concentrations did not differ among seasons (p > .05), but a pattern of secretion along the day showed variations with higher concentrations in the afternoon during the winter. Ejaculate volume was higher during summer; however, sperm motility decreased in summer and spring. Total sperm in ejaculate, sperm morphology and testicular biometry kept constant along the year showing no differences among the seasons. The results demonstrated that in a tropical region, reproductive aspects of stallions did not show a clearly defined seasonal variation, and months of autumn and winter were not unsuitable for reproduction of the males.

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“…2010; Ren et al. 2010), but so far, in the male horse, stress‐induced increases in cortisol concentration decreased testosterone release without affecting LH secretion (Wiest et al. 1988; Rabb et al.…”

Section: Discussionmentioning

confidence: 99%

Gene Expression of ACTH, Glucocorticoid Receptors, 11βHSD Enzymes, LH‐, FSH‐, GH Receptors and Aromatase in Equine Epididymal and Testicular Tissue

Herrera-Luna¹,

Budik²,

Aurich³

2012

Reprod Domestic Animals

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Glucocorticoids (GCs) are important mediators of the stress response and have been implicated in the function and regulation of testicular functions in different species. In many tissues, intracellular glucocorticoid activity is controlled by either or both of the two known isoforms of 11β-hydroxysteroid dehydrogenase (11βHSD) type 1 and 2, which interconvert active and inactive GCs. Little is known about the effects of stress on fertility in the equine species. The main objective of the present study was to investigate the expression of receptors for GCs and adrenocorticotropic hormone [ACTH, melanocortin 2 receptor (MC2R)] as well 11βHSD1 and 11βHSD2 in male equine epididymal and testicular tissue. In addition, expression of aromatase P-450 and receptors for luteinizing hormone (LHR), follicle stimulating hormone (FSHR) and growth hormone (GHR) was studied. Reverse transcriptase PCR and quantitative real-time PCR were performed in tissue from the epididymis (caput and cauda) and testes collected from nine healthy mature stallions (age 4-10 years). mRNA for ACTH and GC receptors as well as 11βHSD1 and -2 were found in epididymal and testicular tissue. Expression of the genes studied was always positive in testicular tissue, while it was inconsistent in epididymal tissue. Quantitative gene expression in relation to β-actin and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was significantly correlated (R = 0.403, p < 0.001). Quantitative PCR in relation to β-actin revealed significant differences in the gene expression of 11βHSD1, 11βHSD2, LHR, FSHR, MC2R and aromatase between tissue collected from caput epididymidis, cauda epididymidis and testicular parenchyma (p < 0.05). With GAPDH, differences between tissues were significant for 11βHSD1, 11βHSD2 and MC2R (p < 0.05) In addition, high concentrations of mRNA of aromatase and receptors of LH and FSH were found in testicular tissue, while a pronounced expression of GH receptor was present in epididymal tissue. The results support the hypothesis of an interaction between the pituitary-adrenal axis and testicular function in the stallion.

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Effect of administration of adrenocorticotropic hormone on plasma concentrations of testosterone, luteinizing hormone, follicle stimulating hormone and cortisol in stallions

Cited by 11 publications

References 15 publications

Increased cortisol release and transport stress do not influence semen quality and testosterone release in pony stallions

Increased cortisol release and transport stress do not influence semen quality and testosterone release in pony stallions

Testosterone serum profile, semen characteristics and testicular biometry of Mangalarga Marchador stallions in a tropical environment

Gene Expression of ACTH, Glucocorticoid Receptors, 11βHSD Enzymes, LH‐, FSH‐, GH Receptors and Aromatase in Equine Epididymal and Testicular Tissue

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