Effect of administration of antihelminthics for soil-transmitted helminths during pregnancy

Salam, Rehana A; Haider, Batool A; Humayun, Quratulain; Bhutta, Zulfiqar Ahmed

doi:10.1002/14651858.cd005547.pub3

Cited by 59 publications

(47 citation statements)

References 31 publications

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“…42 No effects on the risk of LBW or PTB were seen for antihelminthics administration compared with control (see online supplementary table 13).…”

Section: Soil-transmitted Helminthiasis Preventive Chemotherapymentioning

confidence: 97%

“…[35][36][37] There was one review on protein supplementation and nutritional education 38 and two reviews reported on marine oil and fatty acid supplementation. 39 40 One review evaluated reduced salt intake, 41 one deworming 42 and two reviews preventive antimalarial drugs. 43 44 Methodological quality of the included reviews Sixteen reviews were of high quality.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Effects of nutrition interventions during pregnancy on low birth weight: an overview of systematic reviews

et al. 2017

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IntroductionLow birth weight (LBW, birth weight less than 2500 g) is associated with infant mortality and childhood morbidity. Poor maternal nutritional status is one of several contributing factors to LBW. We systematically reviewed the evidence for nutrition-specific (addressing the immediate determinants of nutrition) and nutrition-sensitive (addressing the underlying cause of undernutrition) interventions to reduce the risk of LBW and/or its components: preterm birth (PTB) and small-for-gestational age (SGA).MethodsWe conducted a comprehensive literature search in MEDLINE, EMBASE, CINAHL and the Cochrane Database of Systematic Reviews (September 2015). Systematic reviews of randomised controlled trials focusing on nutritional interventions before and during pregnancy to reduce LBW and its components were eligible for inclusion into the overview review. We assessed the methodological quality of the included reviews using A Measurement Tool to Assess Reviews (AMSTAR), PROSPERO: CRD42015024814.ResultsWe included 23 systematic reviews which comprised 34 comparisons. Sixteen reviews were of high methodological quality, six of moderate and only one review of low quality. Six interventions were associated with a decreased risk of LBW: oral supplementation with (1) vitamin A, (2) low-dose calcium, (3) zinc, (4) multiple micronutrients (MMN), nutritional education and provision of preventive antimalarials. MMN and balanced protein/energy supplementation had a positive effect on SGA, while high protein supplementation increased the risk of SGA. High-dose calcium, zinc or long-chain n-3 fatty acid supplementation and nutritional education decreased the risk of PTB.ConclusionImproving women’s nutritional status positively affected LBW, SGA and PTB. Based on current evidence, especially MMN supplementation and preventive antimalarial drugs during pregnancy may be considered for policy and practice. However, for most interventions evidence was derived from a small number of trials and/or participants. There is a need to further explore the evidence of nutrition-specific and nutrition-sensitive interventions in order to reach the WHO’s goal of a 30% reduction in the global rate of LBW by 2025.

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“…42 No effects on the risk of LBW or PTB were seen for antihelminthics administration compared with control (see online supplementary table 13).…”

Section: Soil-transmitted Helminthiasis Preventive Chemotherapymentioning

confidence: 97%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Effects of nutrition interventions during pregnancy on low birth weight: an overview of systematic reviews

et al. 2017

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“…Additional articles cited within the articles found in the search were also included, as were articles previously known to the author through past research, for example, the articles cited in my past study 4. Other authors have conducted recent meta-analyses of helminth treatment during pregnancy,5,6 while for topics other than treatment, the identified articles reflected substantial heterogeneity in research context and methods, or were very few in number. Thus, in order to provide as broad an overview as possible, formal inclusion and exclusion criteria were not applied to the located articles, and instead, all articles with relevant and interpretable findings are discussed.…”

Section: Review Methodologymentioning

confidence: 99%

“…However, these and additional studies have also found that treatment has limited effects on maternal and infant health. Both a meta-analysis conducted in 20125 and a more recent Cochrane review6 found that antihelminth treatment had no clear overall effect on maternal anemia, low birth weight, or perinatal mortality. The 2012 review found a reduction in very low birth weight, but this was based only on one study with a significant effect and one without 5,69…”

Section: Antihelminth Treatment During Pregnancymentioning

confidence: 99%

Helminth infection during pregnancy: insights from evolutionary ecology

Blackwell

2016

IJWH

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Helminths are parasitic nematodes and trematodes, grouped together because of morphological similarities and commonalities in the effects infections have on hosts. These include complications such as anemia and biasing of immune responses, which can alter susceptibility for other diseases. For pregnant women, these complications might have implications for pregnancy outcomes or neonatal health. Here, I review studies of helminth infections during pregnancy, and ask the following questions: Do helminths affect maternal health or pregnancy outcomes? Are there consequences of maternal infection for infants? What are the effects of antihelminth treatment during pregnancy? The evidence suggests that the answers to these questions depend on the particular helminth species in question, maternal nutritional status, and the presence or absence of comorbid infection with other species, such as malaria. Moreover, there may also be unexpected consequences of treatment, as maternal infections can affect the priming of infant immune systems, with potential effects on infants later in life. These complex interactions suggest that a consideration of the evolutionary history of human–helminth interactions, as well as the ecological context of infections, can help to clarify an understanding of these host–parasite interactions and provide direction for future investigations.

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“…To date, five trials (totaling 4,265 participants) on deworming with single-dose deworming drugs during pregnancy have been conducted and are summarized in a recent Cochrane review [15]. Results indicated that deworming during pregnancy had no overall effect on maternal anemia, low birthweight, preterm birth, or perinatal mortality.…”

Section: Subgroups Of Wramentioning

confidence: 99%