Effect of Administration of Lead Nitrate to Pregnant Rats on the Lungs in Their Offspring

Лебедько, О А; Ryzhavskii, B. Ya.

doi:10.1007/s10517-005-0369-0

Cited by 2 publications

(3 citation statements)

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“…Pb exposure during pregnancy is associated with a variety of neonatal perturbations, including low birth weight, delayed development and maturation, as well as later developing behavioural outcomes (Chang et al, 2012 ). Experimental studies demonstrated that administration of Pb to pregnant rats produced destructive changes in the brains of their offspring (Lebed'ko & Ryzhavskii, 2005 ; Ryzhavskii et al, 2008 ). Differential gender effects were also observed after in utero exposure to Pb throughout full gestation (Cory-slechta et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Long-term changes in brain cholinergic system and behavior in rats following gestational exposure to lead: protective effect of calcium supplement

Basha

Reddy

2015

Interdisciplinary Toxicology

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Our earlier studies showed that lactational exposure to lead (Pb) caused irreversible neurochemical alterations in rats. The present study was carried out to examine whether gestational exposure to Pb can cause long-term changes in the brain cholinergic system and behavior of rats. The protective effect of calcium (Ca) supplementation against Pb toxicity was also examined. Pregnant rats were exposed to 0.2% Pb (Pb acetate in drinking water) from gestational day (GD) 6 to GD 21. The results showed decrease in body weight gain (GD 6–21) of dams, whereas no changes were observed in offspring body weight at different postnatal days following Pb exposure. Male offspring treated with Pb showed marginal alterations in developmental landmarks such as unfolding of pinnae, lower and upper incisor eruption, fur development, eye slit formation and eye opening on postnatal day (PND) 1, whereas significant alterations were found in the righting reflex (PNDs 4–7), slant board behavior (PNDs 8–10) and forelimb hang performance (PNDs 12–16). Biochemical analysis showed decrease in synaptosomal acetylcholinesterase (AChE) activity and an increase in acetylcholine (ACh) levels in the cortex, cerebellum and hippocampus on PND 14, PND 21, PND 28 and in the four-month age group of rats following Pb exposure. Significant deficits were also observed in total locomotor activity, exploratory behavior and open field behavior in selected age groups of Pb-exposed rats. These alterations were found to be maximal on PND 28, corresponding with the greater blood lead levels observed on PND 28. Addition of 0.02% Ca to Pb reversed the Pb-induced impairments in the cholinergic system as well as in behavioral parameters of rats. In conclusion, these data suggest that gestational exposure to Pb is able to induce long-term changes in neurological functions of offspring. Maternal Ca administration reversed these neurological effects of Pb later in life, suggesting a protective effect of calcium in Pb-exposed animals.

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Section: Introductionmentioning

confidence: 99%

Long-term changes in brain cholinergic system and behavior in rats following gestational exposure to lead: protective effect of calcium supplement

Basha

Reddy

2015

Interdisciplinary Toxicology

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“…Данные клинические наблюдения о роли микроэлементов в формировании хронической патологии легких подтверждены экспериментальными исследованиями. На экспериментальной модели интоксикации свинцом [11] показаны особенности патоморфологических изменений в легких крыс, подвергнувшиеся антенатальному воздействию нитрата свинца (рис. 1).…”

Section: таблица 1 факторы риска развития блдunclassified

“…Виктория Р., 11 Представленное наблюдение иллюстрирует сложность дифференциальной диагностики хронического бронхолегочного заболевания у больного [7,18]. Отягощенный акушерский анамнез, недоношенность, на-личие СДР в периоде новорожденности, повторные обструктивные бронхиты, частые пневмонии с раннего возраста, неэффективность массивной неконтролируемой антибактериальной терапии, клинико-рентгенологические данные, предполагали наличие у ребенка порока развития легкого -гипоплазии нижних долей легкого, с рекомендациями оперативного лечения.…”

Section: частота встречаемости основных клинических симптомов у больнunclassified

Current Issues of Chronic Nonspecific Lung Diseases in Children

Козлов¹,

Лебедько²,

Пичугина³

et al. 2018

Bulletin Physiology and Pathology of Respiration

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This article represents the results of long-term observations, devoted to the problems of chronic non-specific pulmonary diseases (CNPD) in children. In dynamics, for the period 2007-2017, high morbidity and invalidation levels were registered. For the improvement of treatment quality and regular check-in definite estimation of CNPD structure is necessary. Well-time diagnostic of the concrete clinical variant and individual approaches are very important in such patients. The main risk factors for the formation and structure of CNPD in children were studied. The main group of 522 cases (45.8%) consisted of patients with lung malformations complicated by secondary bacterial process. On the basis of clinical and morphological comparisons, there was noted the possibility of developing tissue dysplasia in children, not provided by the approved classification of clinical forms of bronchopulmonary diseases in children. It is also noted that disorders of lung growth and development in children with secondary forms of CNPD, along with defects in the development of anatomical structures, are accompanied by the formation of interstitial processes in the lungs. Different clinical variants of CNPD in children as outcomes of bronchopulmonary dysplasia were noted in 22.8% of cases. There were studied possible causes of the formation of conditionally primary chronic forms of CNPD (23.7% of observations) as the outcome of complicated forms of community-acquired pneumonia, taking into account genetically determined predisposition to chronization of the process, the peculiarity of immune intercellular interactions, disturbance of energy supply of immunocompetent blood cells, the formation of tissue dysplasia of pulmonary tissue. Genetically determined lung diseases were identified in 7.7% of cases. Children with allergic lung diseases and hereditary diseases were not included in the development. The presented structure of CNPD in children is due to the regional peculiarity of hospitalized children, possibly underdiagnosed genetically determined lung diseases. The etiological structure of CNPD was studied, which determines the possibility of targeted antibiotic therapy and specific immunotherapy. The effectiveness of treatment and quality of life depends on the quality of topical diagnosis, clinical, etiological variant of CNPD in children.

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Effect of Administration of Lead Nitrate to Pregnant Rats on the Lungs in Their Offspring

Cited by 2 publications

References 5 publications

Long-term changes in brain cholinergic system and behavior in rats following gestational exposure to lead: protective effect of calcium supplement

Long-term changes in brain cholinergic system and behavior in rats following gestational exposure to lead: protective effect of calcium supplement

Current Issues of Chronic Nonspecific Lung Diseases in Children

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