Effect of Administration of Single Dose GnRH Agonist in Luteal Phase on Implantation Rate of Fresh ICSI Cycles

Abstract

The luteal phase (LP) in the fresh ICSI cycle is insufficient, adequate LP support is one of the approved treatments for improving implantation and pregnancy rates. It is generally known that the LP is inadequate after ovarian stimulation due to negative from supra-physiological blood levels of steroids released by numerous corporal luteal, LH concentrations are low during the luteal phase. In this study, patients were divided into two groups: (40) patients as study group; those who received GnRHa (Decapeptil 0.1 mg), three days after embryo transfer, in addition to conventional luteal phase support (LPS) in the LP to increase the implantation and pregnancy rate in IVF; and their control group (40) received standard LPS only. On the second day of stimulation, blood samples for FSH, LH, TSH, E2, and prolactin were taken. On the day of ovulation induction, measure E2, progesterone, and LH; and on the day of embryo transfers, measure progesterone and LH. The overall characteristics of the patients in both groups were not significantly different. There was also no significant change in the number of total oocytes, mean of metaphase II oocytes percent, cleavage rate, grade I embryo percent, or serum hormones level between the study and control groups (p > 0.05). GnRH agonist treatment in the luteal phase improves clinical pregnancy and implantation rate in fresh ICSI cycles but is not statistically significant.

comparison between the effect of different medical drugs used to improve endometrial receptivity in patients with thin poorly vascularized endometrium

“…It's generally understood that the proper thickness of endometrial and vascularity are required for a successful pregnancy, and multiple theses have reported poor pregnancy scores in women with weak, poorly vascularized endometrium (Kaye et al, 2021). Although physicians disagree on the ideal endometrial thickness for conception, there is agreement that endometrial thickness less than 7 mm on ultrasound is typically regarded sub-optimal for embryo transfer and is linked to a lower chance of pregnancy (Alaa, et al, 2021).. The aim of this study: was to evaluate the effects of different medical drugs used routinely to improve endometrial thickness, vascularity, and pregnancy rates.…”