Effect of Adrenalectomy and Complete Blockade of Adrenergic Function on Mortality from Histamine, Endotoxin, Formalin and Tourniquet Stress in Rats

Krawczak, J; Brodie, Bernard B.

doi:10.1159/000136064

Cited by 5 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has recently been demonstrated in the rat that blockade of adrenerg ic function, which results in a pronounced increase in histamine and en dotoxin lethality, is diminished or completely inhibited by cortisone and epinephrine [7]. Results of further experiments showing (a) that histamine lethality of worm-infected rats is increased without affecting the hypergly cemic response to histamine and epinephrine; (b) that increase in hista mine toxicity achieved by blockade of ^-adrenergic receptors (propranolol) in control rats is not affected by cortisone but diminshed by L-epinephrine, and (c) that increased histamine toxicity of worm-infected rats is not diminished by cortisone and/or L-epinephrine, make it improbable that increase in histamine toxicity in the nematode-infected rat is due to a blockade of the adrenergic function.…”

Section: Discussionmentioning

confidence: 99%

“…Dosages were ex pressed in terms of the salt. To test the hyperglycemic response, L-epinephrine (Flu ka) was freshly dissolved in the same physiological solution and used within 30 min: in experiments on histamine toxicity, L-epinephrine (0.25 mg/kg s.c.) in peanut oil (1:500) was given 30 min before the injection of histamine [7]. Hydrocortisone (SoluCortef® Upjohn; 25 mg/kg s.c.) was administered 3 h, and propranolol (Inderal® ICI; 15 mg/kg s.c.) 30 min before histamine.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Increase in the Sensitivity of the Rat to Histamine Following Infection with Nippostrongylus brasiliensis

Keller¹,

Beeger²

1971

Int Arch Allergy Immunol

View full text Add to dashboard Cite

The present results show that following infection of rats with the nematode, Nippostrongylus brasiliensis, the toxicity of histamine is increased but the hyperglycemic response to histamine and epinephrine is unchanged. In rats pretreated with Haemophilus pertussis vaccine, on the contrary, the increase in toxicity to histamine is accompanied by a blockade of the hyperglycemic response to histamine and epinephrine. Further observations have shown that the hypersensitivity of nematode-infected rats to histamine is not diminished by pretreatment with Β-adrenergic blockers or cortisone together with L-epinephrine. Thus, blockade of the adrenergic function is not an important feature in the increase in histamine lethality of the nematode-infected rat.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Increase in the Sensitivity of the Rat to Histamine Following Infection with Nippostrongylus brasiliensis

Keller¹,

Beeger²

1971

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

Pharmacological Aspects of Endotoxin Effects

Giertz¹

1975

Gram-Negative Bacterial Infections and Mode of Endotoxin Actions

View full text Add to dashboard Cite

Hemodynamic significance of histamine synthesis and histamine H 1 - and H 2 -receptor gene expression during endotoxemia

Matsuda

Hattori

Sakuraya

et al. 2002

Naunyn-Schmiedeberg's Archives of Pharmacology

View full text Add to dashboard Cite

The hypothesis that endotoxemia may modify histamine synthesis or histamine receptor expression and that these changes may contribute to cardiovascular dysfunction was tested in rabbits which were rendered endotoxemic by lipopolysaccharide (LPS; 100 micro g/kg, i.v.). The plasma histamine concentration was elevated shortly after LPS, remaining elevated (a 50-fold increase) over the experimental period of 6 h. The sustained increase in plasma histamine was associated with a time-dependent increase in expression of histidine decarboxylase (HDC) in different tissues including atrium, as determined by Western blot analysis. The H(1)-receptor antagonist diphenhydramine significantly shortened the duration of the initial hypotension and the H(2)-receptor antagonist ranitidine greatly suppressed the lasting tachycardia following LPS injection. Northern blot analysis showed that LPS dramatically induced gene expressions of histamine H(1)- and H(2)-receptors in cardiac tissues. In right atrium isolated from the septic animal, the positive chronotropic effect of histamine was significantly diminished. This was possibly due to a marked reduction in G(s)(alpha) protein expression, indicating the impaired H(2)-receptor cellular signaling. In conclusion, LPS-induced endotoxemia causes prominent increases in production of histamine through induction of HDC and in gene expression of histamine receptors. We suggest that overproduction of histamine may be partly responsible for the hemodynamic alterations of endotoxemia.

show abstract

Effect of Adrenalectomy and Complete Blockade of Adrenergic Function on Mortality from Histamine, Endotoxin, Formalin and Tourniquet Stress in Rats

Cited by 5 publications

References 13 publications

Increase in the Sensitivity of the Rat to Histamine Following Infection with <i>Nippostrongylus brasiliensi</i><i>s</i>

Increase in the Sensitivity of the Rat to Histamine Following Infection with <i>Nippostrongylus brasiliensi</i><i>s</i>

Pharmacological Aspects of Endotoxin Effects

Hemodynamic significance of histamine synthesis and histamine H 1 - and H 2 -receptor gene expression during endotoxemia

Contact Info

Product

Resources

About