Effect of Adrenalin on Blood Glucose and Pancreatic Morphology

Volk, Bruno W.; Lazarus, Sydney S.; Lofaro, Patricia

doi:10.1210/endo-65-4-586

Cited by 2 publications

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“…1-3). Discussion C. batrachus is m arkedly sensitive to epinephrine, and the results are com parable with those obtained in mammals [Volk andLazarus, 1959: Boquist, 1967], reptiles [Stevenson et al, 1957;Miller and W urster, 1958: Penhos et al, 1965J, am phibians [Mathews and Zaentz, 1963 Young and Chavin, 1965]. Vorhauer 11938] noted a m arked and long-lasting hyperglycemia in some cyprinoids after large epinephrine doses varying between 5 and 50 mg/kg body weight.…”

Section: Resultssupporting

confidence: 76%

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Histopathology of the endocrine pancreas of a fresh-water fish, <i>Clarias batrachus </i>(L.)

Khanna¹,

Bhatt²

1975

Cells Tissues Organs

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Intramuscular administration of epinephrine in 2 mg/kg and 5 mg/kg body weight doses to Clarias batrachus caused significant hyperglycemia between 12 and 18 h after treatment. The hormone produced a small decrease in the liver glycogen, but induced a notable fall in the glycogen of muscles and a transient increase in the brain glycogen. Light-microscopical examination of the pancreatic islets revealed degranulation and vacuolization of the β-cells accompanied by acute necrosis. Damage to the α-cells was also noticed in hyperglycemic fish. The changes in the cellular configuration of the islets, blood glucose and on the tissue glycogen contents were dose-dependent. It is suggested that epinephrine alters the carbohydrate metabolism through the α-cells of the islets.

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Section: Resultssupporting

confidence: 76%

“…1958: Volk and Lazarus, 1959: Penhos et al, 1965: Boquist, 1967: Trandaburu et al, 1970. The principal metabolic disorder produced by epinephrine administration was found to be enhanced glycogcnolysis in the liver and muscles [Drury and Wick, 1958; Kumar et al.…”

Section: Introductionmentioning

confidence: 99%

Histopathology of the endocrine pancreas of a fresh-water fish, <i>Clarias batrachus </i>(L.)

Khanna¹,

Bhatt²

1975

Cells Tissues Organs

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Hypertrophy of the islets of Langerhans of frog tadpoles after partial pancreatectomy

Frye

1965

J. Exp. Zool.

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Subsequent to incomplete surgical removal of the dorsal pancreatic rudiment of Rana pipiens embryos, islets of Langerhans arise in the pancreas, but in smaller amount than normal. Conpensatory hypertrophy of the beta cells occurs, and the islets are transformed from a larval into an adult histological type. Larval growth and metamorphosis is otherwise unaffected. The evidence supports the hypothesis that metamorphic maturation of the islets of Langerhans is a consequence of an increase in the functional demand on the islets of the frog as compared to the tadpole, and not to direct metamorphic effects of thyroxine. Possible causes for a relatively higher insulin requirement of the frog include (1) an increase in the carbohydrate load on the islets, ( 2 ) an increase in the secretion of hyperglycemic hormones, and ( 3 ) a higher rate of insulin inactivation.

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Effect of Adrenalin on Blood Glucose and Pancreatic Morphology

Cited by 2 publications

References 0 publications

Histopathology of the endocrine pancreas of a fresh-water fish, <i>Clarias batrachus </i>(L.)

Histopathology of the endocrine pancreas of a fresh-water fish, <i>Clarias batrachus </i>(L.)

Hypertrophy of the islets of Langerhans of frog tadpoles after partial pancreatectomy

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