Effect of adrenaline on lymphocyte metabolism and function. A mechanism involving cAMP and hydrogen peroxide

Rosa, Luís Fernando Bicudo Pereira Costa

doi:10.1002/(sici)1099-0844(19970601)15:2<103::aid-cbf729>3.0.co;2-8

Cited by 14 publications

(2 citation statements)

References 35 publications

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“…Rosa and coworkers [43] previously demonstrated the ability of adrenaline to increase the proliferative index of mesenteric lymphocytes and to concomitantly augment the maximal activities of HK, GLUTase, and CS, as well as glucose and glutamine consumption. However, the excess of systemic catecholamines induced by high-intensity, exhaustive exercise could have an immunosuppressive effect, such as a reduction in the plasma levels of interferon- α (IFN α ) and an antiviral cytokine [44].…”

Section: Mediators Of Exercise-induced Immunomodulationmentioning

confidence: 99%

Lymphocyte Glucose and Glutamine Metabolism as Targets of the Anti-Inflammatory and Immunomodulatory Effects of Exercise

Wasinski

Gregnani

Ornellas

et al. 2014

Mediators of Inflammation

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Glucose and glutamine are important energetic and biosynthetic nutrients for T and B lymphocytes. These cells consume both nutrients at high rates in a function-dependent manner. In other words, the pathways that control lymphocyte function and survival directly control the glucose and glutamine metabolic pathways. Therefore, lymphocytes in different functional states reprogram their glucose and glutamine metabolism to balance their requirement for ATP and macromolecule production. The tight association between metabolism and function in these cells was suggested to introduce the possibility of several pathologies resulting from the inability of lymphocytes to meet their nutrient demands under a given condition. In fact, disruptions in lymphocyte metabolism and function have been observed in different inflammatory, metabolic, and autoimmune pathologies. Regular physical exercise and physical activity offer protection against several chronic pathologies, and this benefit has been associated with the anti-inflammatory and immunomodulatory effects of exercise/physical activity. Chronic exercise induces changes in lymphocyte functionality and substrate metabolism. In the present review, we discuss whether the beneficial effects of exercise on lymphocyte function in health and disease are associated with modulation of the glucose and glutamine metabolic pathways.

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Section: Mediators Of Exercise-induced Immunomodulationmentioning

confidence: 99%

Lymphocyte Glucose and Glutamine Metabolism as Targets of the Anti-Inflammatory and Immunomodulatory Effects of Exercise

Wasinski

Gregnani

Ornellas

et al. 2014

Mediators of Inflammation

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“…Adrenaline, which is a physiological accommodation hormone, is secreted by adrenal medulla and released into blood. Adrenaline has prominent functions in promoting catabolism, enhancing glycogenolysis in liver, regulating balance of blood sugar and improving ability of anti-stress ( Rosa, 1997 , Shilov et al., 2005 , Sirota et al., 2008 ). The secretion of AD in body can induce the adaptive changes of the metabolism of carbohydrates, lipids and proteins, so as to relieve the stress effect.…”

Section: Discussionmentioning

confidence: 99%

Effects of octacosanol extracted from rice bran on blood hormone levels and gene expressions of glucose transporter protein-4 and adenosine monophosphate protein kinase in weaning piglets

Long

Sun³

et al. 2015

Animal Nutrition

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The object of this study was to explore the regulatory mechanism of octacosanol to the body of animals and the effects of octacosanol on blood hormone levels and gene expressions of glucose transporter protein (GLUT-4) and adenosine monophosphate protein kinase (AMPK) in liver and muscle tissue of weaning piglets. A total of 105 crossbred piglets ([Yorkshire × Landrace] × Duroc) with an initial BW of 5.70 ± 1.41 kg (21 d of age) were used in a 6-wk trial to evaluate the effects of octacosanol and tiamulin supplementation on contents of triiodothyronine (T3), thyroxine (T4), growth hormone (GH), glucagon (GU) and adrenaline (AD) in blood and gene expressions of GLUT-4 and AMPK in liver and muscle. Piglets were randomly distributed into 3 dietary treatments on the basis of BW and sex. Each treatment had 7 replicate pens with 5 piglets per pen. Treatments were as followed: control group, tiamulin group and octacosanol group. The results showed that compared with control group and tiamulin group, octacosanol greatly promoted the secretion of T3, GH, GU and AD (P < 0.01) and significantly up-regulated the gene expressions of GLUT-4 and AMPK in muscle and liver tissues (P < 0.05). There was no significant difference between the control group and tiamulin group in T3, T4, GH, GU or AD (P > 0.05). Results of the present study has confirmed that octacosanol affects energy metabolism of body by regulating secretion of blood hormones and related gene expression in tissue of weaning piglets, which can reduce stress response and has an impact on performance.

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The effect of adrenaline and Walker-256 tumour-induced cachexia upon Kupffer cell metabolism

Seelaender¹,

Kazantzis²,

Rosa³

1999

Cell Biochem. Funct.

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Kupffer cells (KC), the liver macrophages, are able to produce PGE(2), which is involved in immune suppression and in the aggravation of cancer cachexia due to interference with lipid metabolism in the liver. Since tumour-bearing (TB) rats present high plasma epinephrine levels, and this hormone is able to affect macrophage metabolism and function, we have assessed the effect of epinephrine (5 nM) upon Kupffer cell PGE(2) production. Epinephrine induced increased production of PGE(2) both by control (3.5-fold) and TB rats (27 per cent) KC, an effect blocked by propranolol. Enhancement of cAMP content in the cells by addition of isoproterenol (0.1 microM) to the incubations, however, failed to induce the same response in the cells. Nevertheless, when phenylephrine (1 microM) was added to the incubation, a similar pattern of PGE(2) production to that observed for epinephrine was found for control and TB rat KC. We propose that the effect of epinephrine upon KC PGE(2) production is mediated by alpha-adrenergic receptors and that Ca(2+) is involved in the response, since increasing concentrations of the ion added to the incubation medium (0.25, 0.5 and 1.0 mM) enhanced the eicosanoid production, while EDTA abolished the response.

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Effect of adrenaline on lymphocyte metabolism and function. A mechanism involving cAMP and hydrogen peroxide

Cited by 14 publications

References 35 publications

Lymphocyte Glucose and Glutamine Metabolism as Targets of the Anti-Inflammatory and Immunomodulatory Effects of Exercise

Lymphocyte Glucose and Glutamine Metabolism as Targets of the Anti-Inflammatory and Immunomodulatory Effects of Exercise

Effects of octacosanol extracted from rice bran on blood hormone levels and gene expressions of glucose transporter protein-4 and adenosine monophosphate protein kinase in weaning piglets

The effect of adrenaline and Walker-256 tumour-induced cachexia upon Kupffer cell metabolism

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