Effect of adrenergic stimulation on ornithine decarboxylase activity in the rat spleen

Stefanelli, Claudio; Flamigni, Flavio; Carati, Daniela; Rossoni, Carmen

doi:10.1016/0306-3623(86)90054-6

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…In the present study, we report that the ,6-adrenergic agonist isoprenaline causes the accumulation of NA-acetylspermidine in the rat heart. A similar effect was also found in the spleen, where polyamine synthesis is activated by adrenergic stimulation [15].…”

Section: Introductionsupporting

confidence: 56%

“…Isoprenaline and other catecholamines exert large effects on some functions of the spleen, especially the capacity of storing and releasing blood cells, through their action on the capsula and the vascular system of the spleen [24]. Catecholamines can also elicit a large increase in ODC activity and putrescine concentration in this organ [15]. Therefore it seems that Nl-acetylspermidine formation may be part of the general response of target tissues to fl-receptor stimulation, as well as ODC induction [25].…”

Section: Discussionmentioning

confidence: 99%

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Accumulation of N1-acetylspermidine in heart and spleen of isoprenaline-treated rats

Stefanelli¹,

Carati²,

Rossoni³

et al. 1986

Biochemical Journal

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N1-Acetylspermidine is not detectable in rat heart, but its content greatly increases after a single injection of isoprenaline (10 mg/kg), reaching a concentration of about 10 nmol/g of tissue 4 h after the treatment. Part of the accumulated N1-acetylspermidine was split to putrescine. Isoprenaline also caused an increase of N1-acetylspermidine in the spleen, where its concentration increased 3.5-fold 6 h after the catecholamine. The accumulation of N1-acetylspermidine was dependent on the dose of isoprenaline in both the heart and the spleen, and was strongly inhibited by beta-antagonists and inhibitors of protein synthesis.

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Section: Introductionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Accumulation of N1-acetylspermidine in heart and spleen of isoprenaline-treated rats

Stefanelli¹,

Carati²,

Rossoni³

et al. 1986

Biochemical Journal

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Ornithine decarboxylase and ornithine decarboxylase‐inhibiting activity in rat thymocytes

Stefanelli

Rossoni

Ferrari

et al. 1992

Cell Biochemistry & Function

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Isolation of thymocytes from rat thymus resulted in the disappearance of the high activity of ornithine decarboxylase (ODC) that characterizes the thymus of young rats, together with the appearance of an antizyme-like ODC inhibiting activity, which showed a chromatographic profile that resembled that of dexamethasone-treated rat thymus. Omission of serum or addition of dexamethasone or spermidine did not affect appreciably the extent of the antizyme-like activity. On the other hand, a variety of hormonal effectors, i.e. insulin, glucagon, adrenalin and T3, as well as the phorbol ester, PMA or the mitogen, concanavalin A (Con A) induced ODC activity in cultured thymocytes together with the disappearance of the antizyme-like activity. A paradoxical, transient induction of ODC was caused by the transcriptional inhibitor, actinomycin D. Complexed ODC was detected in rat thymus, but not in thymocytes, either quiescent or stimulated by mitogens. These results indicate that thymic lymphocytes can express either ODC activity or its inhibitor depending on the hormonal and proliferative status of the cells.

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Modification of ornithine decarboxylase activity by adrenergic stimulation in cultured chicken spleen cells

Colombatto

Fasulo

Grillo

1989

International Journal of Biochemistry

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Effect of adrenergic stimulation on ornithine decarboxylase activity in the rat spleen

Cited by 6 publications

References 14 publications

Accumulation of N1-acetylspermidine in heart and spleen of isoprenaline-treated rats

Accumulation of N1-acetylspermidine in heart and spleen of isoprenaline-treated rats

Ornithine decarboxylase and ornithine decarboxylase‐inhibiting activity in rat thymocytes

Modification of ornithine decarboxylase activity by adrenergic stimulation in cultured chicken spleen cells

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