Effect of advanced parental age on pregnancy outcome and offspring health

Zhang, Cong; Yan, Liying; Qiao, Jie

doi:10.1007/s10815-022-02533-w

Cited by 20 publications

(14 citation statements)

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“…We also created an indicator variable for pregnancy awareness after 6 weeks of gestation, which is after the observed median in our data (5 weeks) and also after the mean (5.5 weeks) observed in other research [33,34]. Finally, we dichotomized parental age variables in two ways based on prior literature demonstrating a parabolic pattern of risk for adverse outcomes in children [34][35][36][37] The nal set of questions regarding prenatal risk pertained inquired separately about substance exposure in pregnancy (yes/no) prior to and after pregnancy awareness. We created indicator variables for prescription medications, tobacco, alcohol, and illicit drugs (which included prescription medications used to get high and/or not prescribed to them; i.e., oxycontin, benzodiazepines, barbiturates, or amphetamines or methamphetamine, heroine or morphine, marijuana, cocaine or crack, cathinones, fake or synthetic marijuana, GHB, hallucinogens, inhalants, ketamine, MDMA, opioids) throughout pregnancy (i.e., collapsed across pregnancy awareness).…”

Section: Methodsmentioning

confidence: 99%

Setting a research agenda for examining early risk for elevated cognitive disengagement syndrome symptoms using data from the ABCD cohort

Wiggs,

Cook,

Lodhawala

et al. 2024

Preprint

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Background. Little research has examined early life risk for symptoms of cognitive disengagement syndrome (CDS) despite a well-established literature regarding co-occurring outcomes (e.g., attention-deficit/hyperactivity disorder). The current study estimated bivariate associations between early life risk factors and CDS in a large and representative sample of U.S. children. Methods. We conducted secondary analyses of baseline data from the Adolescent Brain Cognitive Development (ABCD) study (N = 8,096 children, 9–10 years old). Birthing parents reported early life risk factors on a developmental history questionnaire, including parental, prenatal, delivery and birth, and developmental milestone information. They also completed the Child Behavior Checklist, which includes a CDS subscale that was dichotomized to estimate the odds of elevated CDS symptoms (i.e., T-score > 70) in children related to risk indices. Results. We observed significantly elevated odds of CDS related to parental risk factors (i.e., unplanned pregnancy, pregnancy awareness after 6 weeks, teenage parenthood), birthing parent illnesses in pregnancy (i.e., severe nausea, proteinuria, pre-eclampsia/toxemia, severe anemia, urinary tract infection), pregnancy complications (i.e., bleeding), prenatal substance exposures (i.e., prescription medication, tobacco, illicit drugs), delivery and birth risk factors (i.e., child blue at delivery, child not breathing, jaundice, incubation after delivery), and late motor and speech milestones in children. Conclusions. Several early-life risk factors were associated with elevated odds of CDS at ages 9–10 years; study design prevents the determination of causality. Further investigation is warranted regarding early life origins of CDS with priority given to risk indices that have upstream commonalities (i.e., that restrict fetal growth, nutrients, and oxygen).

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Section: Methodsmentioning

confidence: 99%

Setting a research agenda for examining early risk for elevated cognitive disengagement syndrome symptoms using data from the ABCD cohort

Wiggs,

Cook,

Lodhawala

et al. 2024

Preprint

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“…These changes may contribute to the future burden of chronic diseases, given the potential risks of fetal growth restriction. Previous studies have established how maternal age has a "U-shaped" effect on ABOs [10,11]. Although studies have examined secular trends in PTB and LBW in China, these analyses used either age or period as an additional factor.…”

Section: Introductionmentioning

confidence: 99%

Secular trends of low birth weight, preterm birth, and small for gestational age in Shanghai from 2004 to 2020: an age-period-cohort analysis

Zhou

Qian

et al. 2023

Preprint

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Background: Although highly heterogeneous among countries, the incidence rates of low birth weight (LBW), preterm birth (PTB), and small for gestational age (SGA) have been increasing globally over the past two decades. To better understand the cause of the secular trends, this study aimed to clarify the effects of age, period, and birth cohorton adverse birth outcomes in Shanghai. Methods: Data of 2,958,695 singleton live births at 24-41 gestational weeks between 2004 and 2020 were obtained for this study. Age-period-cohort models based on Poisson regression were used to evaluate the independent effects of maternal age, delivery period, and maternal birth cohort on the trends in LBW, PTB, and SGA. Results: The incidence rates of LBW, PTB, and SGA were 2.9%, 4.7%, and 9.3%, respectively, and significant changes were observed (+6.2‰, +6.1‰, and -11.0‰, respectively) from 2004 to 2020. Cohort effect increased steadily, from 1960 (risk ratio [RR] = 0.71, 95% confidence interval [CI]: 0.65-0.78) to 1993 (RR = 0.97, 95% CI: 0.94-1.01) for LBW and from 1960 (RR = 0.69, 95% CI: 0.64-0.75) to 2004 (RR = 1.02, 95% CI: 0.94-1.12) for PTB. A strong cohort effect was found with the highest risk of SGA (RR = 1.82, 95% CI: 1.72-1.93) in 1960 and the lowest risk (RR = 0.57, 95% CI: 0.54-0.61) in 2004, compared with the reference cohort of 1985. There was a “U-shaped” maternal age effect on LBW and PTB and a weak period effect on the three birth outcomes. Conclusions: Our findings suggest a significant independenteffect of age, period, and birth cohort on the three birth outcomes. The increasing rates of LBW and PTB inspired us to focus on young and advanced pregnant women. Meanwhile, the prevalence of SGA decreased steadily, illustrating the need for further research on the mechanisms underlying these trends.

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“…The number of studies on paternal age (PA) and its association with a variety of health outcomes in the offspring has been rising in the literature (Chan & Robaire, 2022), possibly driven by the delayed childbearing phenomenon mainly observed in the developed world where average PA is increasing (Lawson & Fletcher, 2014; Wood & Goriely, 2022; Zhang et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…A major concern in most studies on PA has been adjusting for MA and there seems to be no consensus as to the best way to perform such an adjustment (Lian et al, 1986; Stene, 1978; Stene & Stene, 1977; Wood & Goriely, 2022; Zhang et al, 2022; Zhu et al, 2005). Furthermore, the threshold of age to be defined as “advanced” is not clear and varies among studies (Bray et al, 2006; Wood & Goriely, 2022).…”

Section: Introductionmentioning

confidence: 99%

Paternal age and risk for selected birth defects in a large South American sample

Gili,

Rittler,

Heisecke

et al. 2023

Birth Defects Research

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BackgroundThe relationship between maternal age (MA) and birth defects (BD) has been extensively studied while much less research, mostly with discordant results, has focused on the risk of paternal age (PA) for BD. Furthermore, no consensus has been reached on the best way to control the association of PA with MA.ObjectivesThe aim of the study was to evaluate the risk of PA increase, at 1‐year intervals, for selected BD, especially controlling for the confounding effect of MA.MethodsThe sample comprised of 27,944 liveborns presenting 1 of 18 selected isolated BD. Conditional logistic regressions were applied to evaluate the risk of advanced PA and its yearly increase, adjusting by MA and other variables.ResultsOf the 18 analyzed BD, only the risk for preaxial polydactyly (PreP) showed a significant association with increasing PA, while advanced MA was of low risk. For esophageal and anal atresia, associations with both PA and MA increases were observed.ConclusionsResults support the hypothesis of advanced PA as a risk factor for PreP and helps clarify the so far unexplained nonrandom association between this defect and Down syndrome.

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Effect of advanced parental age on pregnancy outcome and offspring health

Cited by 20 publications

References 204 publications

Setting a research agenda for examining early risk for elevated cognitive disengagement syndrome symptoms using data from the ABCD cohort

Setting a research agenda for examining early risk for elevated cognitive disengagement syndrome symptoms using data from the ABCD cohort

Secular trends of low birth weight, preterm birth, and small for gestational age in Shanghai from 2004 to 2020: an age-period-cohort analysis

Paternal age and risk for selected birth defects in a large South American sample

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