Effect of aerobic interval training on serum IL-10, TNFα, and adipokines levels in women with multiple sclerosis: possible relations with fatigue and quality of life

Mokhtarzade, Motahare; Ranjbar, R; Majdinasab, Nastaran; Patel, Darpan I.; Shamsi, Mahdieh Molanouri

doi:10.1007/s12020-017-1337-y

Cited by 63 publications

(132 citation statements)

References 51 publications

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“…Exercise training (ET) attenuates symptoms and delays the progression of disability in multiple sclerosis (MS) patients, while low levels of physical fitness have been suggested as a risk factor for developing MS . Accordingly, ET has been shown to modulate other autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, and others .…”

Section: Introductionmentioning

confidence: 99%

“…Several studies demonstrated an anti‐inflammatory effect of ET in various mouse models of systemic inflammation . Other studies suggested complex effects of ET on the systemic immune system, including activation of both pro‐ and anti‐inflammatory processes . This discrepancy may derive from the use of protocols of varying exercise intensity that can differentially affect the balance of T cells and pro‐ versus anti‐inflammatory cytokines in mice .…”

Section: Introductionmentioning

confidence: 99%

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Exercise intensity‐dependent immunomodulatory effects on encephalomyelitis

Fainstein

Tyk

Touloumi

et al. 2019

Ann Clin Transl Neurol

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Background Exercise training (ET) has beneficial effects on multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). However, the intensity‐dependent effects of ET on the systemic immune system in EAE remain undefined. Objective (1) To compare the systemic immune modulatory effects of moderate versus high‐intensity ET protocols in protecting against development of EAE; (2) To investigate whether ET affects autoimmunity selectively, or causes general immunosuppression. Methods Healthy mice performed moderate or high‐intensity treadmill running programs. Proteolipid protein (PLP)‐induced transfer EAE was utilized to examine ET effects specifically on the systemic immune system. Lymph node (LN)‐T cells from trained versus sedentary donor mice were transferred to naïve recipients and EAE severity was assessed, by clinical assessment and histopathological analysis. LN‐T cells derived from donor trained versus sedentary PLP‐immunized mice were analyzed in vitro for proliferation assays by flow cytometry analysis and cytokine and chemokine receptor gene expression using real‐time PCR. T cell‐dependent immune responses of trained versus sedentary mice to the nonautoantigen ovalbumin and susceptibility to Escherichia coli‐induced acute peritonitis were examined. Results High‐intensity training in healthy donor mice induced significantly greater inhibition than moderate‐intensity training on proliferation and generation of encephalitogenic T cells in response to PLP‐immunization, and on EAE severity upon their transfer into recipient mice. High‐intensity training also inhibited LN‐T cell proliferation in response to ovalbumin immunization. E. coli bacterial counts and dissemination were not affected by training. Interpretation High‐intensity training induces superior effects in preventing autoimmunity in EAE, but does not alter immune responses to E. coli infection.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exercise intensity‐dependent immunomodulatory effects on encephalomyelitis

Fainstein

Tyk

Touloumi

et al. 2019

Ann Clin Transl Neurol

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“…Multiple sclerosis is a common and unpredictable neurological disease of the central nervous system (CNS) (Mokhtarzade et al, 2017). The cause of multiple sclerosis is currently unknown, but seemingly involves an environmental trigger of the immune system that results in demyelination and impaired remyelination processes with the CNS of genetically susceptible persons (Motl and Pilutti, 2012;Motl et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Such an immune-mediated process involves disruption of the blood-brain barrier (BBB) (Roh et al, 2016) as well as a lack of neurotrophic support for repair (Bansi et al, 2013;Wens et al, 2016;Zimmer et al, 2017). The outcome of CNS demyelination is associated with impaired nervous conduction and reduction in motoric and cognitive abilities (Mokhtarzade et al, 2017;Solari, 2015).…”

Section: Introductionmentioning

confidence: 99%

Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis

et al. 2018

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Blood-brain barrier (BBB) and neurotrophic factors seemingly have an important role in multiple sclerosis pathology. Physical activity may influence blood-brain barrier function and levels of neurotrophic factors, and such effects might be moderated by body weight status. This study investigated the effect of exercise training on markers of blood-brain barrier permeability and neurotrophic factors as a function of weight status in multiple sclerosis patients. Sixty three persons with relapsing remitting multiple sclerosis who were normal weight (n: 33) or overweight (n: 33) were randomly assigned into groups of exercise (normal weight training, n: 18; overweight training group, n: 18) or no exercise (normal weight control, n: 15; overweight control group, n: 15). The intervention consisted of 8 weeks (3 days per week) of cycling undertaken at 60-70% peak power. Resting blood concentrations of s100 calcium-binding protein B (s100b) and neuron-specific enolase as BBB permeability markers, neurotrophic factors and cytokines (Interleukin-10 and tumor necrosis factor alpha) were evaluated before and after the intervention. There were significant weight, training, and interaction effects on brain-derived neurotrophic factor and platelet-derived growth factor; however, ciliary neurotrophic factor and nerve growth factor did not demonstrate any effect. Brain-derived neurotrophic factor and platelet-derived growth factor were significantly increased from pre-post in normal weight exercise. Significant weight, training, and interaction effects were found for s100b. In detail, s100b was significantly increased from pre-post in normal weight exercise. In contrast, neuron-specific enolase and cytokines did not demonstrate any effect. Generally, Exercise training may alter markers of BBB permeability and neurotrophic factor status in normal weight persons with multiple sclerosis; however, overweight participants may be more resistant to these effects of exercise.

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“…The proportion of Th17 cells and IL17 were also found to be higher in patients suffering from MS . Marked reduction of TNF‐α levels following aerobic training effectively improved life quality in women with MS . A significant reduction in serum TNFα/IL‐10 ratio has also been recorded in MS patients after 2 years of treatment with IFNβ‐1b .…”

Section: Discussionmentioning

confidence: 91%

Serum pro‐inflammatory and anti‐inflammatory cytokines and the pathogenesis of experimental autoimmune encephalomyelitis

et al. 2019

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Experimental autoimmune encephalomyelitis (EAE) as an experimental model of multiple sclerosis (MS) is characterized by demyelination, infiltration of inflammatory cells into the nervous system and dysregulation of serum inflammatory cytokines. We investigated the correlation of serum cytokines and other inflammatory markers with the EAE pathogenesis. After EAE induction, the levels of different serum cytokine/inflammatory mediators were measured. Furthermore, motor functions, myelination, and lymphocyte infiltration in EAE mice were also assessed. Our results revealed that the serum concentrations of Thelper 1 (Th1) and Th17 cytokines, interleukin (IL)-6, IL-1β, IL-1α and prostaglandin E2 in EAE mice were significantly higher than controls. The ratios of pro-to anti-inflammatory cytokines were different between the EAE and the control group. A statistically significant positive correlation was found between the IL-6/IL-10 ratio and the EAE severity, demyelination rate, and lymphocyte infiltration in EAE mice. Results indicate that the profiles of serum pro-and anti-inflammatory cytokines might be useful as biomarkers for monitoring the pathological manifestation of EAE. Furthermore, evaluating the dynamic interplay of serum cytokine levels and the correlation with pathogenic mechanisms of EAE may provide diagnostic and therapeutic insights for MS and some other inflammatory disorders.

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Effect of aerobic interval training on serum IL-10, TNFα, and adipokines levels in women with multiple sclerosis: possible relations with fatigue and quality of life

Cited by 63 publications

References 51 publications

Exercise intensity‐dependent immunomodulatory effects on encephalomyelitis

Exercise intensity‐dependent immunomodulatory effects on encephalomyelitis

Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis

Serum pro‐inflammatory and anti‐inflammatory cytokines and the pathogenesis of experimental autoimmune encephalomyelitis

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