Effect of aerobic interval training on erythrocyte rheological and hemodynamic functions in heart failure patients with anemia

Fu, Tieh‐Cheng; Lien, Hen-Yu; Wang, Chao-Hung; Hsu, Chih‐Chin; Wu, Wei-Chin; Chien, Yu Wen; Cherng, Wen‐Jin

doi:10.1016/j.ijcard.2012.11.053

Cited by 21 publications

(31 citation statements)

References 30 publications

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“…The first 2 mL of blood was discarded, and the remaining blood was used to measure hematological parameters. Blood cells were counted using a Sysmax SF-3000 cell counter (GMI Inc., Ramsey, MN) (15,30,31).…”

Section: Methodsmentioning

confidence: 99%

“…Erythrocyte shape was assessed by FACScan flow cytometric techniques (Becton Dickinson), as described in previous studies (30,31). Briefly, FACScan histograms showed a typically bimodal distribution of erythrocytes, which reflected biconcave erythrocytes as essentially two populations of cells in flow cytometric analysis.…”

Section: Methodsmentioning

confidence: 99%

“…The erythrocyte suspension (1 Â 10 4 cells per microliter) was incubated with saturating concentrations of monoclonal anti-human CD71 antibody conjugated with phycoerythrin (DB Pharmingeni) and Vybrant Dyecycle Green (Invitrogen) in the dark for 30 min at 37-C and washed with HBSS twice. Finally, the count of CD71 + reticulocytes obtained from 50,000 erythrocytes was measured using a twocolor FACScan flow cytometer (Becton Dickinson) (8,30,31).…”

Section: Methodsmentioning

confidence: 99%

“…Erythrocyte deformability was determined at various fluid shear stresses (0-35 Pa) by laser diffraction analysis using a slit-flow ektacytometer (RheoScan-D system; InCyto) (22), as described recently (15,30,31). In this experiment, washed erythrocytes were resuspended in a solution of 0.14 mM polyvinylpyrrolidone (molecular weight, 360,000) (Sigma) at the optimal hematocrit of 1.0%.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, alternating aerobic and anaerobic metabolic responses caused by AIT may serve as preconditioning to hypoxic stress, which may increase resistance to hypoxia-induced physiological dysfunction (4,32). Recent studies further demonstrated that cycling AIT significantly improved O 2 uptake efficiency by enhancing hemodynamic response to exercise and by suppressing oxidative stress/inflammation associated with cardiac dysfunction in patients with heart failure (10,28,30). However, no study has investigated the distinct effects of cycling interval and continuous exercise regimens on the rheological characteristics and band 3 activity of erythrocytes under hypoxic conditions.…”

mentioning

confidence: 99%

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Cycling Exercise Training Alleviates Hypoxia-Impaired Erythrocyte Rheology

Chou

Huang

Fu³

et al. 2016

Medicine &Amp; Science in Sports &Amp; Exercise

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Cycling Exercise Training Alleviates Hypoxia-Impaired Erythrocyte Rheology

Chou

Huang

Fu³

et al. 2016

Medicine &Amp; Science in Sports &Amp; Exercise

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Effects of concentric and eccentric cycling training on muscular hemodynamic and erythrocyte rheological responses to exercise in sedentary males

Huang,

Chen,

Lin

et al. 2024

European Journal of Sport Science

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Erythrocyte rheological properties contribute to the dynamic regulation of vascular resistance to flow shear force, facilitating blood delivery from the heart to peripheral tissues. Despite improved physical performance, the effects of eccentric cycling training (ECT) on erythrocyte rheological characteristics remain unclear. This study investigates the distinct effects of ECT and concentric cycling training (CCT) on muscular hemodynamic and erythrocyte rheological responses to exercise. Thirty‐nine sedentary healthy males were randomly assigned to either ECT (n = 13) or CCT (n = 13) at 45%–70% of the maximal workload for 30 min/day, 5 days/week for 6 weeks, or to a control group (n = 13) that did not receive any exercise intervention. A graded exercise test (GXT) was performed before and after the intervention. Muscular hemodynamic and erythrocyte rheological responses to the GXT were determined by near‐infrared spectroscopy and ektacytometry, respectively. Both ECT and CCT significantly enhanced perfusion (Δ[THb]VL) and O2 extraction (Δ[HHb]VL) in vastus lateralis during GXT. Before training, an acute GXT significantly reduced erythrocyte deformability and increased aggregability, whereas after 6 weeks of either ECT or CCT, the extent of erythrocyte rheological changes caused by GXT was diminished. Moreover, CCT elicited higher improvements in cardiac output (CO), VO2, and work‐rate at peak performance than ECT. In hierarchical regression, the change of maximal CO was the most influential factor affecting VO2max following CCT. In contrast, enhanced VO2max was significantly associated with Δ[HHb]VL and erythrocyte aggregability/deformability in ECT. Although CCT is superior to ECT for increasing aerobic capacity, either ECT or CCT effectively enhances aerobic efficiency by improving muscular hemodynamic and erythrocyte rheological responses to exercise.

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