Effect of age and cycloplegia on the morphology of the human crystalline lens: swept-source OCT study

Li, Zhangliang; Qu, Wenyong; Huang, Jinhai; Meng, Ziqi; Li, Xiuyuan; Zou, R.; Zhao, Yune

doi:10.1097/j.jcrs.0000000000000693

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…The CVs of the SC diameter, CSA, SC volume, TM area and TM height were 20.0, 26.5, 35.6, 16.7, and 13.0%, respectively. Acceptable repeatability and reproducibility of the lens morphologies using this SS-OCT has been reported in our previous study (Li et al, 2021).…”

Section: Resultssupporting

confidence: 73%

The Relationship Between Age and the Morphology of the Crystalline Lens, Ciliary Muscle, Trabecular Meshwork, and Schlemm’s Canal: An in vivo Swept-Source Optical Coherence Tomography Study

Meng

et al. 2021

Front. Physiol.

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Purpose: To evaluate the effects of age on the morphologies of the crystalline lens, ciliary muscle (CM), Schlemm’s canal (SC), and trabecular meshwork (TM) using swept-source optical coherence tomography (SS-OCT).Methods: Images of the crystalline lens and iridocorneal angle were obtained in healthy participants’ eyes using SS-OCT. Morphological parameters of the crystalline lens, CM, and TM/SC were measured, and the relationship between these parameters and age was evaluated.Results: A total of 62 healthy participants were enrolled, with an age range of 7–79 years. With adjustments for the effects of axial length and sex, both the nasal and temporal SC cross-sectional areas (CSA) and the cross-sectional area of the CM (CMA), distance from the scleral spur to the inner apex of the ciliary muscle (IA-SS), and nasal SC volume were negatively correlated with age (P ≤ 0.041). Meanwhile, the lens thickness (LT) (P < 0.001) and lens vault (LV) (P < 0.001) were positively correlated with age, and the radius of the curvature of the anterior lens (ALR) was negatively correlated with age (P < 0.001).Conclusion: Increasing age was associated with a thicker crystalline lens, a steeper anterior lens curvature, an anteriorly located and smaller CM, and a narrower SC.Clinical Trial Registration:https://register.clinicaltrials.gov/prs/app/action/Select Protocol?sid=S000A3JZ&selectaction=Edit&uid=U00019K7&ts=4&cx=-c5xxp8, identifier [NCT04576884].

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Section: Resultssupporting

confidence: 73%

The Relationship Between Age and the Morphology of the Crystalline Lens, Ciliary Muscle, Trabecular Meshwork, and Schlemm’s Canal: An in vivo Swept-Source Optical Coherence Tomography Study

Meng

et al. 2021

Front. Physiol.

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“…Techniques include analysing B‐scan images generated by optical coherence tomography (OCT) 5–9 and phakometry, in which lens surface curvatures are determined from the size of the images formed by the different reflecting surfaces 1–3,10–13 . Such techniques have been used to assess lens shape changes during accommodation, 3,4,8,9,14–16 as well as with age and cycloplegia 17,18 …”

Section: Introductionmentioning

confidence: 99%

“…Such techniques have been used to assess lens shape changes during accommodation, 3,4,8,9,[14][15][16] as well as with age and cycloplegia. 17,18 Most phakometry studies determine lens surface shape in a single meridian, or assume the surfaces are spherical. 3,[19][20][21][22] Information about astigmatism can be obtained using measurements from more than one meridian (multimeridional phakometry).…”

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confidence: 99%

Measurement of in vivo lens shapes using IOLMaster 700 B‐scan images: Comparison with phakometry

Pradhan,

Hughes,

Pieterse

et al. 2024

Ophthalmic Physiologic Optic

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PurposeThis study compared in vivo crystalline lens shape measurements using B‐scan images from the IOLMaster 700 with phakometry.MethodsTwenty‐four young adult participants underwent IOLMaster 700 and phakometry measurements under cycloplegia (1% cyclopentolate). The IOLMaster 700 generated B‐scan images along six meridians in 30° increments, which were analysed using custom MATLAB software to determine lens surface radii of curvature. Phakometry measurements were obtained using Purkinje images reflected from the lens surfaces.ResultsThe IOLMaster 700 image analysis method yielded a lower mean anterior lens surface spherical equivalent power (+6.20 D) than phakometry (+7.55 D); however, the two measurements were strongly correlated (R(21) = 0.97, p < 0.0001). The astigmatic power vectors (J0 and J45) for the anterior lens surface were significantly higher for the IOLMaster 700 measurements, with only J0 showing a significant moderate positive correlation (R(21) = 0.57, p = 0.005). For the posterior lens surface, the IOLMaster 700 measurements had a higher mean spherical power (+14.28 D) compared to phakometry (+13.70 D); however, a strong positive correlation (R(21) = 0.90, p < 0.0001) was observed. No significant correlations were noted for posterior lens surface astigmatic vectors (J0 and J45). The IOLMaster 700 estimates for the equivalent lens mean spherical power were slightly lower than those for phakometry, with a mean difference of −0.72 D, and both methods were positively correlated (R(21) = 0.94, p < 0.0001).ConclusionsThe findings demonstrate that IOLMaster 700 B‐scan image analysis technique provides similar estimates of lens surface powers to phakometry. These results highlight the potential of the IOLMaster 700 to provide measurements of lens shape, informing future research and clinical use.

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Associations of ocular anterior segment structures with sex and age: the Yamagata study (Funagata)

Namba,

Maeda,

Tsukamoto

et al. 2024

Jpn J Ophthalmol

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Effect of age and cycloplegia on the morphology of the human crystalline lens: swept-source OCT study

Abstract: The crystalline lens revealed steepening anterior surface and increasing equatorial diameter with age. Cycloplegia caused significant changes on the anterior surface, and this effect weakened with age.

Cited by 5 publications

References 30 publications

The Relationship Between Age and the Morphology of the Crystalline Lens, Ciliary Muscle, Trabecular Meshwork, and Schlemm’s Canal: An in vivo Swept-Source Optical Coherence Tomography Study

The Relationship Between Age and the Morphology of the Crystalline Lens, Ciliary Muscle, Trabecular Meshwork, and Schlemm’s Canal: An in vivo Swept-Source Optical Coherence Tomography Study

Measurement of in vivo lens shapes using IOLMaster 700 B‐scan images: Comparison with phakometry

Associations of ocular anterior segment structures with sex and age: the Yamagata study (Funagata)

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