Effect of age and race on the survival of men with prostate cancer in the Metropolitan Detroit tricounty area, 1973 to 1987

Pienta, Kenneth J.; Demers, Raymond Y.; Hoff, M.; Kau, Tsui-Ying; Montie, James E.; Severson, Richard K.

doi:10.1016/s0090-4295(95)96996-9

Cited by 117 publications

(49 citation statements)

References 8 publications

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“…Although a prior Surveillance, Epidemiology and End Results (SEER) study from Detroit suggested that AA men with advanced cancer had poorer disease-specific survival than stage matched white men, 10 Optenberg et al has found no racial difference in survival for advanced prostate cancer in a large military experience. 6 However, Thompson et al recently analyzed 1387 patients enrolled in a multi-center trial of orchiectomy alone vs orchiectomy plus flutamide for stage D2 disease finding worse disease-specific survival for AA men.…”

Section: Discussionmentioning

confidence: 99%

Primary hormonal therapy for prostate cancer: experience with 135 consecutive PSA-ERA patients from a tertiary care military medical center

Koff

Connelly

Bauer

et al. 2002

Prostate Cancer Prostatic Dis

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The use of prostate specific antigen (PSA) in the 1990s has brought on a stage migration of prostate cancer. Despite that, many men have still presented with metastatic prostate cancer in the past decade. The use of primary hormone therapy in the PSA era at a tertiary care Army Medical Center is studied in this paper. Charts were reviewed of 135 men who were diagnosed with metastatic prostate cancer and treated with hormone therapy as a primary treatment between 1989 and 1995. Statistical analysis was used to determine significant predictor variables on the time to disease progression. In univariate analysis clinical stage, pretreatment alkaline phosphatase and nadir PSA values were significant predictors of time to progression. Race and type of treatment were not. In multivariate analysis the relative risk of progression was 3.2 for patients with an alkaline phosphatase > 252 and 16.5 for patients with a nadir > 2.0. This study supports the argument that racial disparities in prostate cancer outcomes are due to access to care. Furthermore, the survival rate for patients with D-2 disease is better than in the pre PSA studies. Clinical stage, pretreatment alkaline phosphatase and PSA nadir can be used to predict response for those men presenting with metastatic prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Primary hormonal therapy for prostate cancer: experience with 135 consecutive PSA-ERA patients from a tertiary care military medical center

Koff

Connelly

Bauer

et al. 2002

Prostate Cancer Prostatic Dis

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show abstract

“…1 Race/ethnicity and age influence PCa diagnosis, treatment, and outcomes. [2][3][4][5][6][7][8][9][10][11][12] For localized and regional disease stages, Caucasian men are more likely to receive radical prostatectomy and African-American men are more likely to receive radiation. 4 African-American men who receive radical prostatectomy have often exhibited more adverse pathological features than Caucasians.…”

mentioning

confidence: 99%

Ethnic variation in return to baseline values of patient‐reported outcomes in older prostate cancer patients

Jayadevappa

Johnson

Chhatre

et al. 2007

Cancer

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BACKGROUND.Ethnic variation in patient‐reported outcomes such as health‐related quality of life (HRQoL) and satisfaction with care are understudied areas in the management of elderly prostate cancer (PCa) patients.METHODS.In this prospective cohort study, between the years 2002 and 2004, the authors recruited 214 older (≥65 years) men with newly diagnosed PCa from an urban academic hospital and a Veterans Administration hospital. Participants completed generic (SF‐36), prostate‐specific (UCLA‐PCI) HRQoL, and satisfaction with care (CSQ‐8) surveys at baseline and at 3, 6, and 12‐months follow‐up. Clinically significant difference was used to compute return to baseline. The authors compared time to return to baseline HRQoL after controlling for confounding variables by using ANOVA and log‐linear models. Survival curves were used to compare time to return to baseline across ethnicity.RESULTS.Regression analysis revealed that age and marital status, not ethnicity, were independent predictors of radical prostatectomy, rather than radiation treatment. African Americans reported lower HRQoL scores at diagnosis and required a longer time to return to baseline. Log‐linear analysis indicated that African‐American ethnicity was associated with lower 12‐month scores for role physical (odds ratio [OR], 0.46; standard error [SE], 0.40), role emotional (OR, 0.37; SE, 0.43), bodily pain (OR, 0.74; SE, 0.10), urinary function (OR, 0.90; SE, 0.11), and urinary bother (OR, 0.72; SE, 0.17). Both groups reported comparably high levels of satisfaction with care.CONCLUSIONS.African‐American elderly exhibited poorer outcomes and required a longer time to return to baseline HRQoL. These differences highlight the need for discussion with patients and families prior to treatment about expectations and the need for support services post‐treatment. Cancer 2007. © 2007 American Cancer Society.

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“…The Wayne State University group now has a cohort of 928 radical prostatectomy patients and in subset analysis of those operated between January 1991 to December 1993, the PSA-recurrence rate in blacks is 34.2% versus 22.4% in whites. 52 To date, however, our study 43 is the only one to suggest that blacks have higher PSA-recurrence in multivariate analysis and further work is needed.…”

Section: Radical Prostatectomy In African American Menmentioning

confidence: 89%

“…In Table 5 we have summarized a number of series of radical prostatectomy comparisons in black and white men. Moul et al, 43 and Powell et al, 44 found that blacks had signi®cantly higher pretreatment PSA and positive surgical margins. Conversely, Ibrahim et al, 46 and Fowler et al, 22 in smaller experiences, found no signi®cant differences in organ-con®ned or marginpositive rates by race.…”

Section: Radical Prostatectomy In African American Menmentioning

confidence: 99%

“…Along similar lines, a recent SEER database study in metropolitan Detroit found that blacks had a poorer survival than whites in all stages of disease that was especially evident in younger men (`65). 43 Powell et al, 44 also found that survival was worse for African American men under age 65 y but better for men over age 65 y and used the phrase,`ethnic survival crossover'. More study needs to be done to determine if younger black men do have a worse survival and, if so, the cause of this disparity.…”

mentioning

confidence: 99%

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Prostate cancer in African American men

1998

Prostate Cancer Prostatic Dis

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Effect of age and race on the survival of men with prostate cancer in the Metropolitan Detroit tricounty area, 1973 to 1987

Cited by 117 publications

References 8 publications

Primary hormonal therapy for prostate cancer: experience with 135 consecutive PSA-ERA patients from a tertiary care military medical center

Primary hormonal therapy for prostate cancer: experience with 135 consecutive PSA-ERA patients from a tertiary care military medical center

Ethnic variation in return to baseline values of patient‐reported outcomes in older prostate cancer patients

Prostate cancer in African American men

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