Effect of Age and Sex on Blood Pressure, Development of Renal Hypertension, and Concentration of Nitric Oxide in the Blood of Albino Rats

Anishchenko, T. G.; Semyachkina-Glushkovskaya, O.; Berdnikova, V. A.; Sindyakova, T.

doi:10.1007/s10517-010-0859-6

Cited by 3 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In aged rats exposed to the high dose of desflurane systolic blood pressure significantly increased in the third and fourth hours of anesthesia. Mean blood pressure has been reported to be higher in aged compared with adult rats [2]. Importantly, in the aged rats, 1.5 MAC of desflurane did not lead to hypotension (systolic blood pressure increased), negating cerebral hypoperfusion as a mechanism for the poorer acquisition memory at 1 week post exposure.…”

Section: Discussionmentioning

confidence: 84%

Memory Impairment in Rats after Desflurane Anesthesia is Age and Dose Dependent

Callaway

Jones

Royse

et al. 2015

JAD

View full text Add to dashboard Cite

Post-operative cognitive dysfunction (POCD) predominantly affects the elderly who suffer memory and concentration deficits after anesthesia and surgery. Animal studies have demonstrated anesthetic alone may contribute to POCD but results are variable and little is known about common anesthetics other than isoflurane. The present study investigated dose-dependence of desflurane anesthesia in young adult and aged rats. We hypothesize higher concentrations of desflurane will result in memory impairment in the water maze and that impairment will be worse in aged rats. Effects of anesthesia (1 or 1.5 MAC, 4 h) desflurane, or sham exposure on cognition were investigated in young adult (3 months) and aged (20-24 months) rats at 1, 4, and 12 weeks post-exposure. The Morris water maze was used to assess acquisition and retention of spatial reference memory. Latency to find the hidden platform and swimming speed were compared between treatments. Aged rats showed significant impairment in task acquisition after exposure to 1.5 MAC, but not 1.0 MAC desflurane anesthetic when tested 1 week following exposure. Latency to find the platform and distance travelled were significantly longer in aged rats given 1.5 MAC desflurane (latency: F(1,108) = 19.71, p < 0.0001; distance: F(1,108) = 5.79, p = 0.018). Deficits were not long-lasting and were no longer present at 4 or 12 weeks. In contrast, young adult rats performed equally as well as sham-exposed control rats irrespective of desflurane dose. This study showed the effects of desflurane on learning and memory in the water maze are age and dose dependent and are brief in duration.

show abstract

Section: Discussionmentioning

confidence: 84%

Memory Impairment in Rats after Desflurane Anesthesia is Age and Dose Dependent

Callaway

Jones

Royse

et al. 2015

JAD

View full text Add to dashboard Cite

show abstract

Age Determines the Magnitudes of Angiotensin II-Induced Contractions, mRNA, and Protein Expression of Angiotensin Type 1 Receptors in Rat Carotid Arteries

Vámos

Cseplo

Ivić³

et al. 2013

The Journals of Gerontology Series A: Biological Sciences and M

View full text Add to dashboard Cite

In this study, we hypothesized that aging alters angiotensin II (Ang II)-induced vasomotor responses and expression of vascular mRNA and protein angiotensin type 1 receptor (AT1R). Thus, carotid arteries were isolated from the following age groups of rats: 8 days, 2-9 months, 12-20 months, and 20-30 months, and their vasomotor responses were measured in a myograph after repeated administrations of Ang II. Vascular relative AT1R mRNA level was determined by quantitative reverse-transcriptase polymerase chain reaction and the AT1R protein density was measured by Western blot. Contractions to the first administration of Ang II increased from 8 days to 6 months and then they decreased to 30 months. In general, second administration of Ang II elicited reduced contractions, but they also increased from 8 days until 2 months and then they decreased to 30 months. Similarly the AT1R mRNA level increased from 8 days to 12 months and then decreased to 30 months. Similarly the AT1R protein density increased from 8 days until 16 months and then they decreased to 30 months. The pattern of these changes correlated with functional vasomotor data. We conclude that aging (newborn to senescence) has substantial effects on Ang II-induced vasomotor responses and AT1R signaling suggesting the importance of genetic programs.

show abstract

From Newborn to Senescence Morphological and Functional Remodeling Leads to Increased Contractile Capacity of Arteries

Ivić¹,

Vámos

Cseplo

et al. 2016

GERONA

View full text Add to dashboard Cite

Aging induces substantial morphological and functional changes in vessels. We hypothesized that due to morphological remodeling the total contractile forces of arteries increase, especially in older age as a function of age. Mean arterial blood pressure of rats and morphological and functional characteristics of isolated carotid arteries rats, from newborn to senescent, were assessed. The arterial blood pressure of rats increased significantly from 0.25 to the age of 6 months, and then it reached a level, which was maintained until age of 30 months. Wall lumen and wall thickness increased with age, mostly due to media (smooth muscle) thickening, whereas wall tension gradually reduced with age. Contractions of arteries to nonreceptor-mediated vasomotor agent (KCl, 60mM) increased in three consecutive age groups, whereas contractility first increased (until 2 months), then it did not change further with aging. Norepinephrine-induced contractions initially increased in young age and then did not change further in older age. These findings suggest that during normal aging due to remodeling of arterial wall (smooth muscle) the contractile capacity of arteries increases, which seems to be independent from systemic blood pressure. Thus, arterial remodeling can favor the development of increased circulatory resistance in older age.

show abstract

Effect of Age and Sex on Blood Pressure, Development of Renal Hypertension, and Concentration of Nitric Oxide in the Blood of Albino Rats

Cited by 3 publications

References 9 publications

Memory Impairment in Rats after Desflurane Anesthesia is Age and Dose Dependent

Memory Impairment in Rats after Desflurane Anesthesia is Age and Dose Dependent

Age Determines the Magnitudes of Angiotensin II-Induced Contractions, mRNA, and Protein Expression of Angiotensin Type 1 Receptors in Rat Carotid Arteries

From Newborn to Senescence Morphological and Functional Remodeling Leads to Increased Contractile Capacity of Arteries

Contact Info

Product

Resources

About