Effect of age and sex on the ascorbic acid content of kidney, skeletal muscle and pancreas of common indian toad, Bufo melanostictus

Panda, A K; Ruth, R.P.; Padhi, S.N.

doi:10.1016/0531-5565(84)90011-1

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…On the other hand, in the liver of male toads, the parameter showed a peak with increase in size up to age group III and then declined significantly [67] (table 8). In other tissues (kidney, skeletal muscles, pancreas) of the same species, inconsistent patterns of age changes were reported [68], These inconsis tent changes do not clearly correlate with the role of ascorbic acid as anti-oxidant during amphibian ageing.…”

Section: Anti-oxidantsmentioning

confidence: 96%

Ageing in Amphibians

Kara

1994

Gerontology

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Limited research findings up-to-date with a few amphibian models do not permit a generalisation of ageing phenomena in the class Amphibia. Short-lived species of amphibians show gradual senescence comparable to the pattern seen in laboratory mammals. Long-lived species (mostly urodeles) continue to grow throughout life and are believed to exhibit very slow or negligible senescence which is unobtrusive. In a few species with gradual senescence, there is some evidence of an increase in mortality rate and a decrease in growth rate with advancing age. Increase in cross-linking of collagen, accumulation of age pigments (lipofuscin and melanin), decrease in metabolism and loss of immunocompetence are ageing phenomena common to both amphibians and mammals. On the other hand, persistence of neurogenesis and myogenesis, continuance of oogenesis beyond adult life and polyphyodonty are some of the features peculiar to ageing in amphibians. More authenticated reports are needed to fill up the gaps in our knowledge on amphibian senescence.

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Section: Anti-oxidantsmentioning

confidence: 96%

Ageing in Amphibians

Kara

1994

Gerontology

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“…In fact, Tiidus et al [ 27 ] showed that male rats had significantly higher VC levels in the plantaris muscle than female rats, although tissue VC levels were generally unaffected by acute exercise in either gender. Panda et al [ 28 ] also showed that VC levels in skeletal muscle reduced with aging in both male and female toads and slight sex-based differences were observed during aging. Moreover, Jiao et al [ 29 ] reported a sex difference in the expression levels of oxidative stress genes associated with VC by genome-wide gene expression profiles using L-gulonolactone oxidase ( Gulo )-deficient mice, which were unable to synthesize VC.…”

Section: Discussionmentioning

confidence: 99%

Vitamin C Is Essential for the Maintenance of Skeletal Muscle Functions

Takisawa

Takino

Lee

et al. 2022

Biology

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Vitamin C (L-ascorbic acid, VC) is a water-soluble antioxidant essential for collagen polymerization. Previously, we reported that long-term VC deficiency causes muscle atrophy and deterioration in physical ability using female senescence marker protein-30 (SMP30)-deficient mice with a lack of VC synthesis, which is similar to that observed in humans. To determine whether these findings also hold true for male SMP30-deficient mice, two-month-old male SMP30-deficient mice were divided into two groups: the VC-treated group (VC(+)) was administered 1.5 g/L VC, and the VC-untreated group (VC(−)) was supplied water without VC. The VC level at four weeks in the gastrocnemius muscles from the VC(+) and VC(−) groups was 205.7 ± 8.5 nmol/g tissue and 13.1 ± 0.6 nmol/g tissue, respectively. Thus, four weeks was enough to reduce the VC level in the skeletal muscle in the VC-untreated group. On the other hand, muscle weights of the gastrocnemius, soleus, plantaris, tibialis anterior, and extensor digitorum longus in the VC(−) group were significantly reduced by VC deficiency after twelve weeks. The physical endurance of the VC(−) group at eight weeks was markedly lower than that of the VC(+) group. The grasping strength and activity in the cage in the nocturnal phases of the VC(−) group were markedly lower at twelve and sixteen weeks than those of the VC(+) group. Interestingly, muscle atrophy and declined physical ability were completely restored with VC supplementation for twelve weeks after VC deficiency. Thus, VC is essential for maintaining skeletal muscle function in both male and female SMP30-deficient mice with a lack of VC synthesis.

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“…Thus the study provided evidence to support an investigation on the gender difference when lacking VC in humans. In animal study, a sex difference has also been evidenced [5, 6]. …”

Section: Introductionmentioning

confidence: 99%

Genome Wide Analysis of Sex Difference in Gene Expression Profiles of Bone Formations UsingsfxMice and BXD RI Strains

Huang

Zhu

Wang

et al. 2014

The Scientific World Journal

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The objective of this study is to identify sex differentially expressed genes in bone using a mouse model of spontaneous fracture, sfx, which lacks the gene for L-gulonolactone oxidase (Gulo), a key enzyme in the ascorbic acid (AA) synthesis pathway. We first identified the genes that are differentially expressed in the femur between female and male in sfx mice. We then analyzed the potential gene network among those differentially expressed genes with whole genome expression profiles generated using spleens of female and male mice of a total of 67 BXD (C57BL/6J X DBA/2J) recombinant inbred (RI) and other strains. Our result indicated that there was a sex difference in the whole genome profiles in sfx mice as measured by the proportion of up- and downregulated genes. Several genes in the pathway of bone development are differentially expressed between the male and female of sfx mice. Comparison of gene network of up- and downregulated bone relevant genes also suggests a sex difference.

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Effect of age and sex on the ascorbic acid content of kidney, skeletal muscle and pancreas of common indian toad, Bufo melanostictus

Cited by 7 publications

References 11 publications

Ageing in Amphibians

Ageing in Amphibians

Vitamin C Is Essential for the Maintenance of Skeletal Muscle Functions

Genome Wide Analysis of Sex Difference in Gene Expression Profiles of Bone Formations UsingsfxMice and BXD RI Strains

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