Effect of age at exposure on chromosome abnormalities in MIC-exposed Bhopal population detected 30 years post-disaster

Ganguly, Bani Bandana; Mandal, Shouvik; Banerjee, Nalok; Kadam, Nitin N.; Abbi, Rita

doi:10.1016/j.mrfmmm.2018.03.005

Cited by 5 publications

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Exposure to metals in CKD patients can lead to reductions in kidney functions [36]. Thus, the confounders can be a lifestyle, living environment, nutritional factors, drinking water, and occupational exposure to other toxicants [37]. It was opined that alterations in NDI value are directly related to the proliferative ability of the cell [38].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cytogenetic Alterations of Toxic Gas Exposed Population of Bhopal Having Chronic Kidney Disease

Samarth

Tiwari

Modi³

et al. 2021

Preprint

View full text Add to dashboard Cite

The industrial disaster of Bhopal in 1984 resulted in widespread morbidity and mortality in the vicinity of the industry and required long-term surveillance for chronic health effects in those affected by the leakage of gas. Although few cytogenetic studies were undertaken to assess genetic damage in survivors of the disaster, no studies are available on cytogenetic damage of toxic gas-exposed populations having chronic kidney disease (CKD). Thus, the present study aimed to evaluate cytogenetic alterations in chronic kidney disease patients who were exposed to leaked gas and to compare it with those who were not exposed to the leaked gas. The cytogenetic alterations were evaluated through chromosomal aberration analysis and micronuclei assay. The study included 608 study participants divided into four groups based on the history of exposure to the leaked gas and the presence or absence of CKD. The results of the study showed no statistically significant difference in cytogenetic damage between gas-exposed and non-exposed patients of CKD. However, significantly higher cytogenetic damage was observed among gas-exposed participants having CKD as compared to gas-exposed participants free from CKD. Thus, to conclude though the cytogenetic alterations were observed in an exposed group it cannot be solely attributed to the gas exposure and the role of other confounders must also be studied.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of Cytogenetic Alterations of Toxic Gas Exposed Population of Bhopal Having Chronic Kidney Disease

Samarth

Tiwari

Modi³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Lesson from the MIC Accident May Guide for Alternative Approaches to Minimize Environmental Pollution

Ganguly,

Kadam

2024

Recent Advances in Environmental Science From the Euro-Mediterranean and Surrounding Regions (4th Edition)

View full text Add to dashboard Cite

Spectrum of stable and unstable rearrangements in lymphocytic chromosomes investigated in Bhopal population 30 years post MIC disaster amid co-exposure to lifestyle, living, and occupational hazards

Ganguly

Kadam

2022

Environ Sci Pollut Res

View full text Add to dashboard Cite

Effect of age at exposure on chromosome abnormalities in MIC-exposed Bhopal population detected 30 years post-disaster

Cited by 5 publications

References 41 publications

Evaluation of Cytogenetic Alterations of Toxic Gas Exposed Population of Bhopal Having Chronic Kidney Disease

Evaluation of Cytogenetic Alterations of Toxic Gas Exposed Population of Bhopal Having Chronic Kidney Disease

Lesson from the MIC Accident May Guide for Alternative Approaches to Minimize Environmental Pollution

Spectrum of stable and unstable rearrangements in lymphocytic chromosomes investigated in Bhopal population 30 years post MIC disaster amid co-exposure to lifestyle, living, and occupational hazards

Contact Info

Product

Resources

About

Effect of age at exposure on chromosome abnormalities in MIC-exposed Bhopal population detected 30 years post-disaster

Cited by 5 publications

References 41 publications

Evaluation of Cytogenetic Alterations of Toxic Gas Exposed Population of Bhopal Having Chronic Kidney Disease

Evaluation of Cytogenetic Alterations of Toxic Gas Exposed Population of Bhopal Having Chronic Kidney Disease

Lesson from the MIC Accident May Guide for Alternative Approaches to Minimize Environmental Pollution

Spectrum of stable and unstable rearrangements in lymphocytic chromosomes investigated in Bhopal population 30 years post MIC disaster amid co-exposure to lifestyle, living, and occupational hazards

Contact Info

Product

Resources

About

Effect of age at exposure on chromosome abnormalities in MIC-exposed Bhopal population detected 30 years post-disaster