Effect of age of onset of temporal lobe epilepsy on the severity and the nature of preoperative memory deficits

Lespinet, Véronique; Bresson, Christel; N’Kaoua, Bernard; Rougier, Alain; Claverie, Bernard

doi:10.1016/s0028-3932(02)00012-x

Cited by 55 publications

(26 citation statements)

References 52 publications

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“…A wrinkle in this literature, alluded to in the Introduction, is that earlier age of seizure onset has been associated with poorer neuropsychological test performance (irrespective of surgical status), compared to later onset seizure disorder (e.g., Dikmen et al, 1975Dikmen et al, , 1977Hermann et al, 2002;Lespinet et al, 2002), which opens the possibility that early onset patients have relatively "less to lose" than late onset patients. It was possible to examine this possibility in some detail in our dataset.…”

Section: Discussionmentioning

confidence: 99%

“…Early-onset seizure patients have been consistently shown to perform more poorly on a wide range of neuropsychological measures as adults, when compared with late-onset patients, and the observed deficits appear to be more generalized and pervasive than would be expected based on what is known about the extent of structural lesion in these patients (Dikmen, Matthews & Harley, 1975;Dikmen, Matthews & Harley, 1977;Hermann et al, 2002;Lespinet, Bresson, N'Kaoua, Rougier & Claverie 2002). O'Leary, Seidenberg, Berent, and Boll (1981) found this age of onset effect even in young children and when controlling for potentially confounding variables such as seizure frequency.…”

Section: Functional Reorganizationmentioning

confidence: 92%

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Age of seizure onset, functional reorganization, and neuropsychological outcome in temporal lobectomy

Griffin

Tranel

2007

Journal of Clinical and Experimental Neuropsychology

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Patients with early onset seizure disorder tend to have less cognitive decline following surgical resection than patients with late onset seizure disorder. Differential opportunity for presurgical cerebral functional reorganization has been proposed to account for this "age of onset" effect. However, the relationships between age of seizure onset, functional organization, and neuropsychological outcome remain incompletely understood. To shed additional light on these issues, we investigated 66 patients with anterior temporal lobectomies (37 left; 29 right), all of whom completed comprehensive neuropsychological assessment prior to and following surgical resection. The sample was divided into two groups: 34 patients with early onset (EO) epilepsy and 32 patients with late onset (LO) epilepsy. We found the typical age of onset effect: post-surgically, EO patients demonstrated relatively better outcome in multiple neuropsychological domains, especially verbal memory, compared to LO patients. Based on presurgical Wada testing, 23 patients were classified as having traditional cerebral functional organization (TFO) and 35 were classified as having nontraditional cerebral functional organization (NTFO). The NTFO group had an earlier age of seizure onset than the TFO group, and NTFO was more frequent in EO patients (70%) than LO patients (50%). NTFO patients demonstrated relatively better post-surgical outcome in several neuropsychological domains, compared to TFO patients. Our findings are consistent with the notion that functional reorganization may be an explanatory factor for the better neuropsychological outcome of EO epilepsy patients following anterior temporal lobectomy.

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Section: Discussionmentioning

confidence: 99%

Section: Functional Reorganizationmentioning

confidence: 92%

Age of seizure onset, functional reorganization, and neuropsychological outcome in temporal lobectomy

Griffin

Tranel

2007

Journal of Clinical and Experimental Neuropsychology

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“…Adult and child studies across a range of epilepsy syndromes consistently suggest that intellectual and cognitive impairment is greater when seizures begin early rather than later in life [4][5][6][7][8][9][10][11][12]. In support of this view, intellectual outcome is particularly poor if seizures begin prior to the age of five [5,[13][14][15][16][17], with the poorest outcomes associated with seizure onset in the first year of life [11,18].…”

Section: Introductionmentioning

confidence: 97%

Developmental stage affects cognition in children with recently-diagnosed symptomatic focal epilepsy

Gonzalez

Embuldeniya

Harvey

et al. 2014

Epilepsy & Behavior

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“…These variables include the age of seizure onset (Dikmen, Matthews, & Harley, 1975Hermann et al, 2002;Lespinet, Bresson, N'Kaoua, Rougier, & Claverie, 2002;O'Leary, Seidenberg, Berent, & Boll, 1981), duration of illness (Jokeit & Ebner, 1999;Oyegbile et al, 2004), seizure frequency (McDonald, Delis, Norman, Wetter, Tecoma, & Iragui, 2005c;Thompson & Duncan, 2005), number of anticonvulsant medications (G. K. Motamedi & Meador, 2004), and the presence or type of structural pathology (McDonald, Delis, Norman, Tecoma, & Iragui, 2005a;York et al, 2003). For example, patients with TLE who have an early age of seizure onset have been found to show more pervasive cognitive impairments in general than those with a late seizure onset (Hermann et al, 2002;Lespinet et al, 2002), even after controlling for the duration of illness and seizure frequency . In addition, patients with a left-sided seizure focus have been shown to perform more poorly on a variety of verbal tasks relative to those with right-sided seizure focus (Akanuma et al, 2003;Bell & Davies, 1998;Giovagnoli, 1999Giovagnoli, , 2005Upton & Thompson, 1996).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, patients with a left-sided seizure focus have been shown to perform more poorly on a variety of verbal tasks relative to those with right-sided seizure focus (Akanuma et al, 2003;Bell & Davies, 1998;Giovagnoli, 1999Giovagnoli, , 2005Upton & Thompson, 1996). However, the vast majority of studies examining the influence of these seizure-related variables on cognition included only patients with TLE (Hermann et al, 2002;Jokeit & Ebner, 1999;Lespinet et al, 2002;Oyegbile et al, 2004) or did not differentiate between patients with temporal and nontemporal seizure foci Thompson & Duncan, 2005). In addition, few studies have focused on the effects of disease-related factors in patients with epilepsy on different aspects of executive functioning, such as proverb interpretation (but see Thompson & Duncan, 2005).…”

Section: Introductionmentioning

confidence: 99%

A Componential Analysis of Proverb Interpretation in Patients with Frontal Lobe Epilepsy and Temporal Lobe Epilepsy: Relationships with Disease-Related Factors

McDonald

Delis

Kramer

et al. 2008

The Clinical Neuropsychologist

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The ability to interpret nonliteral, metaphoric language was explored in patients with frontal lobe epilepsy (FLE) and temporal lobe epilepsy (TLE), and matched control participants, to determine (1) if patients with FLE were impaired in their interpretations relative to those with TLE and controls, and (2) if disease-related variables (e.g., age of seizure onset) predicted performances in either patient group. A total of 22 patients with FLE, 20 patients with TLE, and 23 controls were administered a test of proverb interpretation to assess their ability to grasp the abstract meaning of nonliteral language. Participants were presented with a series of proverbs and asked to provide an oral interpretation of each. Responses to each proverb were scored according to their accuracy and level of abstractness. Patients with FLE, but not TLE, were impaired relative to controls in their overall interpretation of proverbs. However, a subgroup analysis revealed that only patients with left FLE showed impaired interpretation accuracy relative to the other groups, whereas patients with both left FLE and left TLE showed impaired abstraction. Patients with FLE were also impaired when they were asked to select the best interpretation of the proverb from response alternatives. In patients with FLE, only a left-sided seizure focus was associated with poorer performance. In patients with TLE, both an early age of onset and a left-sided seizure focus predicted poorer performance. Overall, FLE patients exhibit greater impairment than TLE patients in interpreting proverbs. However, the nature and disease-specific correlates of impaired performances in proverb interpretation differ between the groups.

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Effect of age of onset of temporal lobe epilepsy on the severity and the nature of preoperative memory deficits

Cited by 55 publications

References 52 publications

Age of seizure onset, functional reorganization, and neuropsychological outcome in temporal lobectomy

Age of seizure onset, functional reorganization, and neuropsychological outcome in temporal lobectomy

Developmental stage affects cognition in children with recently-diagnosed symptomatic focal epilepsy

A Componential Analysis of Proverb Interpretation in Patients with Frontal Lobe Epilepsy and Temporal Lobe Epilepsy: Relationships with Disease-Related Factors

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