Effect of Age on Intestinal Absorption of Riboflavin in Humans

Jusko, William J.; Levy, Gerhard; Yaffe, Sumner J.

doi:10.1002/jps.2600590410

Cited by 18 publications

(10 citation statements)

References 11 publications

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“…But the rate of absorption was, similar to D-xylose, significantly lower in newborns. According to the present results it is not very probable that this is exclusively caused by the delayed gastrointestinal passage [9,12].…”

Section: Discussioncontrasting

confidence: 45%

“…Consequently additive absorption mechanisms must be subject to age-dependent changes. Experiments on the absorption of riboflavin in relation to age [9,12] show that this vitamin is absorbed in the upper small intestine by saturation kinetics. The significant parameters of these saturation kinetics, that is, the maximal absorption capacity, was markedly decreased in young infants compared to older children.…”

Section: Discussionmentioning

confidence: 99%

“…The time for maximal blood concentration is much longer in newborns than in older children. Comparable results are obtained on age-dependent absorption of riboflavin [9,12] and D-xylose [13,14].…”

mentioning

confidence: 85%

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The age-dependence of intestinal absorption using d-xylose as an example

1977

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In 40 infants the serum concentrations of D-xylose were measured from capillary blood samples up to 300 min after an oral dosage of 0.5 g of D-xylose per kg body weight. The parameters of the absorption kinetics, which are calculated by a digital computer program, showed an age-dependent behavior. Infants up to the age of 2 months have lower maximal serum concentrations compared to older ones because of a larger volume of distribution. The rate constant of invasion k1, which serves as a measure for the rate of intestinal absorption and the rate constant of elimination k2 were significantly lower in infants up to the age of 2 months compared to older ones. The quotient of k1:k2 was independent of age. The time it took to reach maximal serum concentration was significantly longer in young infants. By adding metoclopramide simultanously to the oral D-xylose doses it could be demonstrated that the slower motility of the gastrointestinal tract in newborns and young infants is not exclusively responsible for the slower rate of absorption of D-xylose. Comparing the absorption rates in 26 infants after different D-xylose dosages a saturation kinetics may be supposed.

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Section: Discussioncontrasting

confidence: 45%

Section: Discussionmentioning

confidence: 99%

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The age-dependence of intestinal absorption using d-xylose as an example

1977

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“…This permits the use of urinary re¬ covery and excretion rate data as a comparative index of intestinal ab¬ sorption of the vitamin. 3 The average values of the two parameters are sig¬ nificantly lower in the patients with biliary obstruction than in normal controls. Also, two children in whom biliary atresia was corrected surgi¬ cally showed increased absorption of the vitamin.…”

Section: Commentmentioning

confidence: 90%

“…[2][3] Because of this characteristic, it was decided to investigate the possible use of riboflavin as a test for the pa¬ tency of the biliary system in infants and children with congenital biliary atresia. In the absence of a normally functioning biliary system, decreased enterohepatic cycling of riboflavin was anticipated.…”

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confidence: 99%

Riboflavin Absorption in Children With Biliary Obstruction

Jusko¹

1971

Arch Pediatr Adolesc Med

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The Gastrointestinal Tract

Holt

1995

Comprehensive Physiology

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The sections in this article are: Salivary Glands Stomach Gastric Secretion Small Intestine Morphology Brush Border Membranes Enzymes Intestinal Permeability Protein Synthesis Intestinal Absorption Gut‐Associated Immune System Splanchnic Blood Flow Gastrointestinal Motility Esophagus Stomach Neuromuscular Functioning Colon and Rectum Pancreas Liver and Biliary Tree Morphology Age‐Associated Effects Consequences of Aging Bile Gastrointestinal Hormones Cellular Proliferation Esophagus and Stomach Small Intestine Colon Effects of Caloric Restriction

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Effect of Age on Intestinal Absorption of Riboflavin in Humans

Cited by 18 publications

References 11 publications

The age-dependence of intestinal absorption using d-xylose as an example

The age-dependence of intestinal absorption using d-xylose as an example

Riboflavin Absorption in Children With Biliary Obstruction

The Gastrointestinal Tract

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