Effect of Age on Optimal Clinical Dose of Dexmedetomidine Sedation

Abstract

Background:Dexmedetomidine is known to be administered for sedation safely even in a very elderly patient. The purpose of this study was to determine the effect of age on clinically optimal dose of dexmedetomidine for sedation. Methods: We enrolled 50 patients ASA class I and II, scheduled for lower extremity surgery that need. They were classified into a young group (n = 26), aged below 75 and an old group (n = 24), aged above 75. Dexmedetomidine was continuously infused 0.5 μg/kg within 10 min, followed by maintenance at a dose of 0.5 μg/kg/min, initially. The next dose was selected using the Dixon's up-and-down method. Results: The cED50 of dexmedetomidine required to maintain optimal sedation level in young and old group were 0.50 and 0.48 μg/kg, respectively. With isotonic regression, cED95 of dexmedetomidine was 0.71 μg/kg (95% confidence intervals 0.57-1.06 μg/kg) and 0.58 μg/kg (95% confidence intervals 0.51-0.67 μg/kg). There were no significant differences in cED50 (P = 0.21), recovery variables, or incidence of side effects between the two groups. Conclusions: Clinically optimal dose of dexmedetomidine was not affected to the age during sedation.

The alternative of oral sedation for pediatric dental care

“…In 2001, Maze et al, [ 21 ] reported decrease in dosage of dexmedetomidine is necessary for patients with liver disease, while it is not necessary for patients with kidney disease. In 2014, Choi et al, [ 22 ] reported no difference in complications between the younger group (average age; 56 years old) and the older group (average age; 78 years old) in a study on 50 patients (age; 20-95 y). Tobias et al, [ 23 ] reported safe usage of dexmedetomidine in infants and children in 2002.…”