Effect of age on safety and efficacy of novel cancer drugs investigated in early-phase clinical trials

Nicolò, Eleonora; Gandini, Sara; Giugliano, Federica; Uliano, Jacopo; D’Ecclesiis, Oriana; Morganti, Stefania; Ferraro, Emanuela; Trapani, Dario; Tarantino, Paolo; Zagami, Paola; Boldrini, Laura; Caramella, Irene; Carnevale Schianca, Ambra; Cristofanilli, Massimo; Locatelli, Marzia Adelia; Esposito, Angela; Belli, Carmen; Minchella, Ida; Criscitiello, Carmen; Marra, Antonio; Curigliano, Giuseppe

doi:10.1016/j.ejca.2024.114181

Cited by 2 publications

(1 citation statement)

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“…These findings highlight the importance of considering genetic factors when assessing lung cancer risk in the elderly population. Supporting this view, Eleonora et al emphasized that elderly cancer patients (over 65 years) were thoroughly evaluated for the safety and efficacy of novel anticancer therapies [ 35 ]. Additionally, Rao et al demonstrated that the ALDH2 rs671 AA genotype increased the risk of developing coronary artery stenosis (CAS) in individuals over 65 years old [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

CD147 TagSNP is associated with the vulnerability to lung cancer in the Chinese population: a case–control study

Xie,

Huang,

Zhou

et al. 2024

Discov Onc

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Background Lung cancer, with its high morbidity and mortality, presents a major significant public health challenge. CD147, linked to cancer progression and metastasis, is a promising therapeutic target, including for lung cancer. The genetic variation may influence the expression of the gene and consequently the risk of lung cancer. This study aims to investigate single nucleotide polymorphisms (SNPs) in CD147 to understand their association with the risk of developing lung cancer in the Han Chinese population. Methods A hospital-based case–control investigation was conducted, enrolling 700 lung cancer patients and 700 cancer-free controls. TagSNPs were selected using Haploview v4.2, and genotype data from the 1000 Genomes Project database were utilized. The selected SNPs (rs28992491, rs67945626, and rs79361899) within the CD147 gene were evaluated using the improved multiple ligation detection reaction method. Statistical analysis included chi-square tests, logistic regression models, and interaction analyses. Results Baseline characteristics of the study population showed no significant differences in gender distribution between cases and controls, but there was a notable difference in smoking rates. No significant associations were found between the three TagSNPs and lung cancer susceptibility in the codominant model. However, stratification analyses revealed interesting findings. Among females, the rs79361899 AA/AG genotype was associated with an increased risk of lung cancer. In individuals aged ≥ 65 years old, the rs28992491 GG and rs79361899 AA genotypes were linked to a higher susceptibility. Furthermore, an interaction analysis demonstrated significant genotype × gender interactions in the rs79361899 recessive model, indicating an increased lung cancer risk in female carriers of the heterozygous or homozygous polymorphic genotype. Conclusions CD147 polymorphisms play an important role in lung cancer development, particularly in specific subgroup of age and gender. These findings highlight the significance of incorporating genetic variations and their interactions with demographic factors in comprehending the intricate etiology of lung cancer.

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Section: Discussionmentioning

confidence: 99%