Effect of age on semen parameters in infertile men after varicocelectomy

Hassanzadeh-Nokashty, Kamaleddin; Yavarikia, Parisa; Ghaffari, Alireza; Hazhir, Samad; Hassanzadeh, Mohammadali

doi:10.2147/tcrm.s17027

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…Collectively, such findings might propose that the inverse relationship between BMI and post-operative semen quality might be age-dependent, being more apparent at younger age groups. Such findings concur with two previous studies that showed better improvement in semen parameters among younger patients after varicocelectomy [ 26 , 27 ].…”

Section: Discussionsupporting

confidence: 93%

Impact of body mass index on semen parameters and reproductive hormones among men undergoing microsurgical subinguinal varicocelectomy

Mahdi

Majzoub

Elbardisi

et al. 2023

Arab Journal of Urology

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Background Few studies assessed the relationships between BMI and post varicocelectomy semen quality and fertility potential and they reported inconsistent findings. Objective To assess the association of BMI with semen parameters and reproductive hormones before and after microsurgical varicocelectomy. Materials and Methods Retrospective chart review in a tertiary infertility center. Of 1170 patients with clinical varicocele during the study period (8 years), 813 patients were eligible and included. Patients were grouped into: Group A (kg/m 2 , n = 251 patients), B (BMI 25–29.9 kg/m 2 , n = 289), C (BMI 30–34.9 kg/m 2 , n = 183) and D (kg/m 2 , n = 90). Clinical data, semen parameters, sperm DNA fragmentation and hormonal profile were collected before and 3 months after microsurgical varicocelectomy. Results Patients’ mean age was 35.87 ± 8.17 years. Higher-grade varicocele was significantly more prevalent in the lower BMI groups. BMI was significantly negatively correlated with preoperative sperm concentration, total motility progressive motility and total motile sperm count. Pre-operatively, sperm concentration, total motility, progressive motility and total motile sperm count showed significant differences between BMI groups, where higher BMI (Groups C and D) exhibited the poorest semen parameters. Postoperatively, all groups showed significant improvement in sperm concentration compared with pre-operative values. However, total and progressive motility were significantly improved in Groups A, B and C, while in Group D (highest BMI), total motility improved clinically but not statistically, progressive motility did not display improvement, and total motile sperm count was significantly improved only in Groups B and C. Postoperatively, mean improvements in semen parameters across the BMI groups were not significantly different, except for morphology, which improved significantly more in the less obese patients. Conclusion For infertile patients with clinical varicocele undergoing micro-surgical varicocelectomy, BMI appears not to impact the improvements across most of the semen parameters and hormones. The procedure might improve the fertility potential.

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Section: Discussionsupporting

confidence: 93%

Impact of body mass index on semen parameters and reproductive hormones among men undergoing microsurgical subinguinal varicocelectomy

Mahdi

Majzoub

Elbardisi

et al. 2023

Arab Journal of Urology

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“…In one study dedicated to looking at the effect of age on post varicocele repair semen outcomes, age was found to be inversely associated with improvements in semen parameters. 24 Patients aged <25 years demonstrated the greatest increase in sperm counts, motility and morphology following varicocelectomy, and there were significant negative correlations between age and improvements in sperm count, motility and morphology. 24 Huang et al .…”

Section: Prevaricocelectomy Factors Predicting Postrepair Semen Parammentioning

confidence: 89%

“… 24 Patients aged <25 years demonstrated the greatest increase in sperm counts, motility and morphology following varicocelectomy, and there were significant negative correlations between age and improvements in sperm count, motility and morphology. 24 Huang et al . found on multivariate logistic regression that age, with an odds ratio of 0.56 (95% confidence interval: 0.41–0.76), had a significant unfavorable association with the likelihood of improvement in semen analysis parameters after varicocelectomy.…”

Section: Prevaricocelectomy Factors Predicting Postrepair Semen Parammentioning

confidence: 89%

Prognostic factors for a favorable outcome after varicocele repair in adolescents and adults

Samplaski

Jarvi

2016

Asian J Androl

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The effect of varicocele repair on male fertility remains controversial. It would be helpful to determined which men would benefit most from varicocele repair, and target repair efforts at those individuals. A detailed review of the literature on prognostic factors for varicocele repair was performed using the PubMed NLM database. We found that the best predictor of postvaricocelectomy semen parameters is the preoperative semen parameters. The greatest improvements in semen parameters were found in men with larger varicoceles. While there is controversy, higher testosterone, younger age and larger testis size, in some studies predict for improvements in semen parameters postvaricocelectomy. A nomogram has been developed to predict the postvaricocelectomy semen parameters based on the preoperative semen parameters, varicocele grade and the age of the man (www.fertilitytreatmentresults.com). Limited data consistently demonstrates the greatest improvements in DNA fragmentation rates in men with higher baseline DNA fragmentation rates. With respect to reproductive outcomes, higher baseline sperm density consistently predicts for natural pregnancy or assisted reproductive technology (ART) pregnancy rates. In addition, varicocele repair does seem to reduce the need for more invasive modalities of ART. In conclusion, we can now start to use specific parameters such as baseline semen quality, varicocele grade and patient age to predict post-repair semen quality and fertility potential following varicocelectomy.

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